Information About

The Survival Triangle

I call my three pillars to beat cancer the “survival triangle.” If you’re serious about keeping (or getting) cancer out of your life, follow these steps to better health. They are simple, proven fighters that will make you a winner against this devastating disease. Taking a single one and making it part of your life will make a huge difference in your overall health.

If you utilize all three, it will change your life.

Now, before anything, let me say that traditional cancer treatment (surgery, chemotherapy, and radiation) does its part to help patients survive cancer.

Unfortunately, they don’t address the root cause of cancer. They treat the tumors that result. They kill the cancer cells and a lot of healthy cells along the way. Conventional cancer modalities treat the disease…not the patient.

Even oncologists who understand that toxins and inflammation are the underlying cause of millions of deaths globally from cancer every year aren’t addressing prevention techniques that will keep these patients from coming back with another cancer in a year or five years.

Addressing the “Alternative Medicine Skeptics”

If you don’t address the cause – the problems that start the cancer ball rolling – then you haven’t really beaten it…you’ve only managed to knock it unconscious for a while.

You have to take control of your health. That requires you to understand how your body works and what it needs to do the best job for you that it can.

If you don’t “believe” in alternative therapies, then you’re doing yourself a great disservice. Even if you fully expect traditional treatment to “cure you,” alternative methods can help you with the side effects you’re going to experience, keep your body stronger, and guard you against another episode of cancer in your future.

Alternative choices can improve your quality of life and help you endure treatments such as radiation that leave the body (and immune system) ravaged and weak. The “war” against cancer leaves as much destruction as a real war. Much like the natural landscape and infrastructure is left annihilated in battle – so is your body after traditional treatment.

Pillar #1 – DIET

Cancer represents the biggest fight of your entire life.  You need to be as fit and healthy as you can be to meet the challenge. In order to handle the demands of exercise, to terminate infection and bacteria, to fight the effects of age, your body is going to need the right fuel.

That is why diet is the first pillar of beating the root causes of cancer.

Anyone (medical professional or otherwise) who tells you that diet does not affect your health or ability to fight disease is a liar. Period.

Diet is everything. Even the World Health Organization (WHO) estimates that around 40% of cancers are caused by diet (I think the numbers are actually much higher). What you choose to put in your mouth may mean the difference between life and death.

That isn’t dramatic, that is fact.

Eating a diet filled with junk food, dyes, preservatives, excess sugar, caffeine, or other “empty” calories cannot and will not feed your body. If your body doesn’t get the right vitamins and minerals – it stops running. Just like a car without gas.

There are many anti-cancer meal plans that I discuss in my books and on Alternative-Doctor.com but there is no universal diet plan that will suit every person equally. Instead, dietary requirements must be assessed based on each individual’s specific needs. Remove any foods (no matter how much you love them) that cause stress to your immune system.

My personal suggestion is to fill your diet with fresh, organic foods (where possible), salads, smoothies, and brightly colored produce. Remember that dairy, soy, grains, and even certain produce can be unknown stressors. Avoid white sugar, white flour, white rice, processed foods, dairy, and soy.

Pillar #2 – Emotional Cleansing

Negative emotion as a root cause of cancer is reality. There is far too much science to back this stance up, so keep an open mind.

Stanford psychiatrist, Dr. David Spiegel, was a skeptic when he began his study on the influence of negativity on breast cancer patients. He was shocked to discover that at the ten-year survival checkup, those women who included therapy in their lives survived twice as long as those who did not.

You read that right…there was a 50% better survival rate by purging negative emotion.

Another Yale research study found that cancer spread faster in women who had “repressed personalities.” They defined the word “repressed” as having intense feelings of hopelessness and not having the ability to express anger, fear, or other negative emotions.

In other words, they bottled it all up inside and it made them sicker, faster.

Stress is known in the traditional and alternative communities as a major cause of inflammation. It is one thing everyone agrees on (though traditional medicine’s answer is another prescription). Inflammation has been discovered at the base of all known diseases.

In other words, stress will kill you through cancer or heart attack or autoimmune disease…if you allow it to control your life. Balanced emotions equal a balanced physiological system.

Pillar #3 – DETOXIFICATION

There are countless stressors in our modern world and many of them are foods, people or situations, and products we allow into our lives. We’ve talked about the first two. Let’s discuss the contamination most people never consider.

Personal pollution is as dire as environmental pollution and we are surrounded by both at every turn. Pollutants are in our soil, water, and air and that means they are in our food supply. Those are harder to control (even organic foods are grown on the same planet we’ve corrupted with countless toxins).

You can control what you put on your body, what you put in your body, and how you maintain the environments you live in most (your home and work space).

If you haven’t heard about the chemical soup found in cosmetics, household goods, and everyday cleansers, I urge you to do some research on it right now. From heavy metals and arsenic to formaldehyde and parabens…products you buy every day at your local market are filled with endocrine disruptors, estrogen mimics, and outright poison to the cells in your body.

One person I urge you to read is Dr. Sam Epstein, a professor of Occupational Health and Environmental Medicine at the University of Illinois School of Public Health.

In his book, The Politics of Cancer, he states, “The NCI (National Cancer Institute) promised annual cancer mortality rates would be halved by the year 2000. The establishment now belatedly admits that cancer rates are increasing sharply. It discounts substantial evidence…the wide range of chemical and radioactive carcinogens permeating the environment, air, water, food, and the workplace. The establishment ignores, let alone investigates, carcinogenic contaminants in dietary fat, particularly pesticides, PCBs, and estrogen (with extensive and unregulated use as growth promoting animals food additives).”

Big Business (food manufacturers, chemical producers, and even personal care manufacturers), and Big Pharma (drugs, drugs, drugs) don’t care about your health. They don’t care about “curing” anything at all because then…how would they make money?

Every time you use cosmetics, shampoos, conditioners, antiperspirants, paints, household cleaning agents, laundry detergent, or any host of other products…you are playing Russian Roulette with your health.

These deadly toxins don’t just pass through your system. No, that would be bad but your (healthy) immune system would be able to control most of the fallout. What makes many of these chemicals so dangerous is that they accumulate in your body, gradually building up (bit by bit) to levels that are toxic according to any agency.

The True Causes of Cancer

There are many things stressing your body each and every day. Junk nutrition, high levels of stress, and chemical contamination push these stressors past the brink of what your body can handle. SOURCE: The Truth About Cancer – Dr. Keith Scott-Mumby – July 11, 2015

What is Tian Xian – a supposed miracle cure? It is very expensive and I can’t find any kind of official statement about its safety or its effectiveness.

This page tells you about Tian Xian – an alternative therapy advertised on the internet for cancer. There is information about

• What Tian Xian is
• Research into Tian Xian
• Side effects of Tian Xian
• Cost of treatment
• About alternative therapies

What isTian Xian?

There is very little information available on this alternative remedy, except from the organizations selling it. They describe it as an alternative dietary food supplement. They say it helps to destroy, control and inhibit cancer by strengthening the body’s immune system. There is some information on the Memorial Slone Kettering herbal remedy website. If you are looking for information on the web, it’s worth knowing that Tian Xian is also written Tien Hsien.

Tian Xian is said to be a cocktail of 14 plant extracts, including ginseng and liquorice. It was invented by a Chinese Professor called Wang Zhen Guo. Tian Xian claims to have won many awards. All those listed by the sellers are from the 38th Eureka World Invention Expo, an organisation we have not heard of. From the information given by the sellers, this remedy is used mostly in the Far East in places such as Hong Kong, China and Malaysia.

The websites selling this product claim that it has been scientifically tested. But these claims are not backed up by any hard evidence. There are no statistics on survival presented. Nor are there any descriptions of controlled clinical trials . A randomised trial is the only way to properly test whether any new drug or remedy actually works. The only information given about tian xian is that it was found to be not inferior to 5FU. Again, no scientific data is given to back this up. What the makers do say is that Tian Xian should be used alongside conventional cancer treatment. It should not be a substitute for chemotherapy, surgery, biological therapy or radiotherapy.

Research into Tian Xian

A few lab studies have looked at Tian Xian with human cells. They show that it may have some immune system effects and may cause cancer cells to die Normal cells have a natural life span but cancer cells carry on multiplying for ever. That’s one of the main differences between cancer cells and normal cells. So substances that encourage them to die off naturally are useful in cancer research. So there is some lab evidence emerging about Tian Xian but no evidence that it works in people yet. As this is a mix of many medicinal herbs, it would be surprising if it didn’t have some effects, but that doesn’t mean it is a cancer cure.

Side effects of Tian Xian

The side effects listed for Tian Xian by sites that sell it are

• Constipation
• Diarrhoea, which may contain blood
• Stomach pain and wind
• Feeling and being sick
• Dizziness
• Racing pulse and raised blood pressure
• Loss of appetite
• Piles
• Aches and pains
• Rashes
• Darkening skin if you have liver cancer

This is quite a list, but there are no official medical reports of harm coming to people who take Tian Xian.

Cost of treatment

Tian Xian is expensive. The makers suggest you take it daily for 6 months, or until your cancer has gone. Then, you are supposed to take it 1 month out of 4 for 2 years. Then for 2 months each year for the next 5 years. The price on the web varies between about $700 and $1,000 for 28 days daily treatment. Even at the cheapest estimate, that works out to be over £9,000 for a full course.

About alternative therapies

There is no proper research evidence that Tian Xian works as a treatment for cancer. We are concerned that these potential cures are often sold for a great deal of money. And people with cancer can be vulnerable. It is understandable that patients or relatives will try anything if they think it might work.

We are also dubious about any remedy that claims to work for all types of cancer. There are over 200 different types of cancer and they do vary. Some respond to one type of treatment and others to another. They have different causes and there are different genetic mutations in the cells of different types of cancer. It is very unlikely that anyone will ever come up with a single treatment that works for all cancer types.

Several years ago, I had a man seeking asparagus for a friend who had cancer.  He gave me a photocopied copy of an article, entitled, `Asparagus for cancer’ printed in Cancer News Journal, December 1979.  

I will share it here, just as it was shared with me: ‘I am a biochemist, and have specialized in the relation of diet to health for over 50 years.  Several years ago, I learned of the discovery of Richard R. Vensal, D.D.S. that asparagus might cure cancer..  

Since then, I have worked with him on his project.  We have accumulated a number of favorable case histories.  

Here are a few examples:  

Case No. 1: a man with an almost hopeless case of Hodgkin’s disease (cancer of the lymph glands) was completely incapacitated.  Within 1 year of starting the asparagus therapy, his doctors were unable to detect any signs of cancer, and he was back on a schedule of strenuous exercise.  

Case No. 2: a successful businessman 68 years old who suffered from cancer of the bladder for 16 years.  After years of medical treatments, including radiation without improvement, he went on asparagus.  Within 3 months, examinations revealed that his bladder tumor had disappeared and that his kidneys were normal.  

Case No. 3: a man had lung cancer.  On March 5th 1971, he was put on the operating table where they found lung cancer so widely spread that it was inoperable.  The surgeon sewed him up and declared his case hopeless.  On April 5th he heard about the asparagus therapy and immediately started taking it..  By August, x-ray pictures revealed that all signs of the cancer had disappeared.  He is back at his regular business routine.  

Case No. 4: a woman was troubled for a number of years with skin cancer.  She finally developed different skin cancers, which were diagnosed by asking specialist as advanced.  Within 3 months after starting on asparagus, her skin specialist said that her skin looked fine and no more skin lesions.  This woman reported that the asparagus therapy also cure her kidney disease, which started in 1949.  She had over 10 operations for kidney stones, and was receiving government disability payments for an inoperable, terminal, kidney condition.  She attributes the cure of this kidney trouble entirely to the asparagus.  

I was not surprised at this result, as `The elements of material medical’, edited in 1854 by a Professor at the University of Pennsylvania, stated that asparagus was used as a popular remedy for kidney stones ..  He even referred to experiments, in 1739, on the power of asparagus in dissolving stones.  

We would have other case histories but the medical establishment has interfered with our obtaining some of the records.  I am therefore appealing to readers to spread this good news and help us to gather a large number of case histories that will overwhelm the medical skeptics about this unbelievably simple and natural remedy.  

For the treatment, asparagus should be cooked before using, and therefore canned asparagus is just as good as fresh.  

I have corresponded with the two leading canners of asparagus, Giant and Stokely, and I am satisfied that these brands contain no pesticides or preservatives.  Place the cooked asparagus in a blender and liquefy to make a puree, and store in the refrigerator.  Give the patient 4 full tablespoons twice daily, morning and evening.  

Patients usually show some improvement in from 2-4 weeks.  It can be diluted with water and used as a cold or hot drink.  This suggested dosage is based on present experience, but certainly larger amounts can do=2 0no harm and may be needed in some cases.  

As a biochemist I am convinced of the old saying that `what cures can prevent’.  Based on this theory, my wife and I have been using asparagus puree as a beverage with our meals.  

We take 2 tablespoons diluted in water to suit our taste with breakfast and with dinner.  I take mine hot and my wife prefers hers cold.  For years we have made it a practice to have blood surveys taken as part of our regular checkups.  

The last blood survey, taken by a medical doctor who specializes in the nutritional approach to health, showed substantial improvements in all categories over the last one, and we can attribute these improvements to nothing but the asparagus drink.  
  
As a biochemist, I have made an extensive study of all aspects of cancer, and all of the proposed cures.  As a result, I am convinced that asparagus fits in better with the latest theories about cancer. Asparagus contains a good supply of protein called histones, which are believed to be active in controlling cell growth.  For that reason, I believe asparagus can be said to contain a substance that I call cell growth normalizer.  That accounts for its action on cancer and acting as a general body tonic.  

In any event, regardless of theory, asparagus used as we suggest, is a harmless substance.  

The FDA cannot prevent you from using it and it may do you much good.  It has been reported by the US National Cancer Institute, that asparagus is the highest tested food containing glutathione, which is considered one of the body’s most potent anti carcinogens and antioxidants. Source: Dr. Gabe Mirkin – Alternative Medicine – February 2009 

Results have been released demonstrating the effectiveness of palladium lipoic complexes (referred to as PdLA and its dietary supplement version, Poly-MVA), a safe nutritional approach for cancer – a disease that according to U.N. and American Cancer Society surveys affects some 2 billion people worldwide.  

In a multiple cell line study, Poly-MVA was shown to be immediately effective against numerous cancer cell lines measured over 72 hours: melanoma, liver, lung, breast, colon, astrocytomoa and glioblastoma. In the prostate cancer line, there was no cell death at 24 hours, but there was tumor cell death seen at 48 hours. One significant benefit of Poly-MVA is that it can be continued indefinitely. Research shows the best results appear to be achieved when it is taken for periods of time of 3 months or greater. 

A patented supplement with over 17 years of testing and clinical research, and over 40 years of laboratory research, Poly-MVA is a nutritional supplement that is uniquely formulated combination of minerals, vitamins and amino acids designed to increase cellular energy production, promote overall health and protection, and support immune system function – particularly in compromised body states. 

Poly-MVA is prepared using a unique method that complexes the ingredients and produces a compound that is safe, effective and supports and protects healthy cells. 

Al Sanchez, Jr., the company’s President and CEO, is excited at the continuing evidence showing the effectiveness of Poly MVA with cancer patients. 

“It has been shown through scientific research, case studies, clinical application, practitioner reports and individual responses that Poly-MVA supports and improves cellular function and has far-reaching positive effects on many systems and functions of the body. Its most notable effects have been with cancer patients, but others are having wonderful results as well,” he commented. “The results of the KGK cell lines are further confirming the important role Poly-MVA can have in directly supporting those dealing with cancer.” 

For more information on Poly-MVA, visit www.polymva.com. 

How Can Poly-MVA Help? 

• Helps the body to produce energy 

• Supports the liver in removing harmful substances from the body 
• Assists in preventing cell damage 
• Assists the body in removing heavy metals from the bloodstream 
• Works as a powerful antioxidant and detoxificant 
• Prevents B-12 deficiency related mental disturbances in the elderly 
• Supports nerve and neurotransmitter function 
• Enhances white blood cell function 
• Supports pH balance, helping to maintain oxygenation of cells and tissues 

Note: Poly-MVA is marketed as a dietary supplement therefore we can not make claims that it treats or cures any disease. All of the information we share in this email comes from scientific research and field reports from our Health Care Practitioners and individuals who have used Poly-MVA.)   

Please checkout the following WEBSITES: 

Home Website  

http://www.polymva.com 

Webcasts of Doctors on Poly-MVA 

http://www.polymva.com/webcasts.html 

Foundation Website  

http://www.facr.org  

 ﷟HYPERLINK “http://www.polymva.com/”    

Dr. Garnett’s Website 

http://www.electrogenetics.net    

Support Group Website 

http://groups.yahoo.com/group/polymva/ 

Survivors Group Website 

http://www.polymvasurvivors.com 

(Mt. Miriam Hospital, Panang, Malaysia) – A human study of a natural herbal compound which containing 50mg of Graviola (annonaceous acetogenin), 30mg of Maitake (beta glucan), 20mg of Maytenus illicifolia (maytansine), 50mg of Cats Claw, 50mg of Suma (pfaffosides), 15mg of Bitter melon (guanylate cyclase and cucurbitacin B) and 20mg of Mutamba (procyanidin b-2) plus a proprietary formula from GenEpic was conducted on various types of humans breast carcinomas, stage 1 through stage 4. The trial was conducted by Dr. Amir Farid Datuk Isahak MD and Dr. Lee Chui Ai PhD at Mt. Miriam Hospital, in Panang, Malaysia. 

Our study spanned six months and involved 210 tests subjects. Due to the time frame involved in the study and the limited number of tests subjects the only requirement of each test subject was a positive mammogram along with an MRI showing a malignant carcinoma in the breast tissue. Our next dilemma was to produce a comparative method to describe what we were seeing. Due to the fact that we were viewing various carcinomas we decided that a total measurement of each subjects tumor thickness, length, and width would be taken and recorded in millimeters, then multiplied by the number of subjects in our study. This number would represent the group as a whole and give us an average size of the whole group.   

Each test subject followed the protocol with monthly interviews and a follow-up MRI after three months with a final after the sixth month. The protocol was three doses of the compound on an empty stomach at 7:00am, 3 doses at 1:00pm, and 3 at 8:00pm 

The following results were seen… 

1st month 

85% of the tests subjects reported a severe reaction to the treatment starting on or about the 5th day. Symptoms included 100% severe fatigue, 22% nausea, 65% headache, 15% skin rash, 10% stiff joints, and 18% bloating and swelling in extremities, 8% diarrhea and 2% stomach cramps. By day 12 over 80% of the symptoms had disappeared while most of the subjects still reported fatigue. It should be noted that many of the patients had reported to their regular physician who subsequently experienced an extreme increase in blood chemical cancer markers during the first few weeks on the protocol. We can only assume this to be a response to the treatment.  

2nd month 

5% of the subjects are still experiencing mild fatigue while 65% have expressed an increase in energy levels. Only 30% remained unchanged. It should be noted that we found during this interview that almost 10% had not followed the protocol on a regular basis. Of these 22 subjects 18 fell into the unchanged category while 4 are still experiencing mild fatigue.  

3rd month 

After reviewing the MRI results from the test subjects we notices a 12% drop in average tumor size. Over 40% of the subjects experienced a 20% reduction or more, while 38% experienced a less than 10% reduction. 7% experienced an average of 3% increase in tumor size while 12% of the group was unchanged. 

4th month  

During month four, 22% of the subjects called in with a reoccurrence of symptoms as expressed in month one. However the severity was drastically reduced to simple headaches, fatigue, and mild diarrhea. 42% of the subjects expressed an increase in energy while the remainder had no particular change in feeling.  

5th month 

During this month 47 of the tests subjects phoned in that a recent mammogram could detect no trace of cancer. We asked each one to continue on the program until we could confirm our results with an MRI.  After the monthly interviews we discovered that 87% had no traceable symptoms of the protocol while 9% were still experiencing headaches. 3% of these subjects have been expressing this since the beginning and on previous health reports before the protocol began complained of migraine like symptoms. 

6th month 

MRI results were conclusive that 178 of the 210 subjects involved have no traceable sign of cancer. 24 of the remaining 32 have experienced a 50% drop in tumor size. Of the remaining eight subjects 3 have experienced a 30% decrease in tumor size while 5 have experienced a combined average increase of 4% in tumor size. All five of these subjects after a consultation have opted to have a complete or partial mastectomy and therefore will not qualify to continue on the protocol.  The 35 remaining subject have agreed to continue with the protocol and a follow-up visit will occur monthly.  

After 12 months of treatment the remaining 35 patient were retested and test results were again conclusive there were no traceable signs of cancer.  The (GenEpic) treatment protocol achieved an overall effective rate of remission of 97.7%.  

In summary, we feel as if these results warrant a review from the directors of this clinic to not only incorporate this protocol in the standard treatment of breast cancer but also ask that funding be provided to incorporate this program along with clinical protocols into other forms of cancer, such as lung, colon, liver, cervical, uterine, prostate, brain, kidney, pancreatic, esophageal and melanoma. 

EDITOR’S Note: 

Optimal Health Research, a U.S. Company, has begun an FDA approved Institutional Review Board (IRB00008666) to conduct a Controlled Clinical Trial to further determine the potential benefit of this compound (GenEpic™).  GenEpic™ has augmented the original formula by including additional vitamins, herbs, and minerals to boost the immune system during the protocol.  GenEpic™ is available to Health Care Professionals throughout the World that would like to include patients in this IRB. 

For additional information and for a domestic (USA) contact regarding participating in a case study protocol, please contact Dr. Steven Osguthorpe, ND at 801-264-8561, or www.ohresearch.com 

Mt. Miriam Hospital, Panang, Malaysia 

Clinical abstract of a multi herbal compound from GenEpic 

A herbal compound consisting of 50mg of Graviola (annonaceous acetogenin), 30mg of Maitake (beta glucan), 20mg of Maytenus illicifolia (maytansine), 50mg of Cats Claw, 50mg of Suma (pfaffosides), 15mg of Bitter melon (guanylate cyclase and cucurbitacin B) and 20mg of Mutamba (procyanidin b-2) were tested for their ability to inhibit the growth of adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) cells. These particular cells are resistant to treatment with adriamycin, vincristine, and vinblastine and is, thus, multidrug-resistant (MDR). The NNI compound was most potent with as much as 250 times the potency of adriamycin, a commonly used chemotherapy drug. A dosage of times the written dose seems to be optimum with single doses less active. Several single compounds in this formula have been proven quite potent, with a particular acetogenin known as gigantetrocin A being the most potent compound tested. The acetogenins may, thus, have chemotherapeutic potential, especially with regard to MDR tumors. 

Dr. Amir Farid Datuk Isahak MDDr. Lee Chui Ai PhD  

In February, I traveled to Baltimore to interview Peter Pedersen, PhD, and Young Hee Ko, PhD, concerning the metabolic approach to cancer and their formulation of a novel anticancer compound, 3-bromopyruvate (3BP).  
 
Pedersen is a legendary figure in the field of cancer metabolism. More than any other living scientist, he has elucidated the various ways–normal and abnormal–that a cancer cell generates its energy. Energy production fuels all cells, including cancer cells. Thus understanding the energy production factories inside cells offers the greatest hope for controlling the growth and spread of cancers.  
 
Pedersen is a seasoned professor of biological chemistry and oncology at the Johns Hopkins University School of Medicine in Baltimore. In addition, he is a member of the Sidney Kimmel Cancer Center, and the Center for Obesity and Metabolism Research, at the same institution. Ko is a former Hopkins researcher who now directs KO Discovery LLC at the University of Maryland’s biomedical research park (BioPark), where we had our meeting.  
 
Pedersen was born in Oklahoma to a part-Cherokee mother and a Danish-American father. He attended American Indian schools through high school and showed an early aptitude for biology. He had the advantage of having an older brother, Lee, who was already determined to be a scientist. After graduating from the University of Tulsa in Oklahoma, both went to graduate school at the University of Arkansas. Here, Lee majored in theoretical chemistry and Peter in biochemistry. Lee subsequently carried out postdoctoral work at Harvard and later became a celebrated professor at the University of North Carolina.  

 
While still at the University of Arkansas, Peter Pedersen focused on work related to muscle contraction while learning in required laboratory experiments about the great German biochemist/physiologist Otto H. Warburg, MD, PhD. Warburg won the 1931 Nobel Prize for his pioneering work on cancer metabolism.  
 
Warburg is generally considered the preeminent biochemist of the first half of the 20th century (Nelson 2008) and was well known for developing an instrument known as the “Warburg apparatus” that was used to measure at a given temperature the amount of gas; for example, oxygen, produced or absorbed by various tissues and cancerous tumors.  
 
Warburg’s most important discovery was that most animal cells produce energy (conserved in the form of adenosine triphosphate, or ATP) by first converting glucose into carbon dioxide and water. This is done through a process called oxidative phosphorylation, or OxPhos for short. OxPhos, which takes place in specialized cellular bodies called mitochondria, is the culminating step in cellular respiration. But cancer, Warburg found, also utilizes an abbreviated form of energy generation called glycolysis (also known as fermentation). This process produces energy (ATP) by converting glucose into lactic acid. As Pedersen summed it up in our interview: “Most normal animal cells rely heavily on the mitochondria for their energy needs but when transformed to become cancer cells, particularly the most malignant, they rely significantly on both mitochondria and glycolysis.”  
 
This ability to use both forms of energy generation gives a cancer cell flexibility. It can survive where oxygen is abundant but also where it is in short supply (such as in the interior of a dense tumor). Plus, glycolysis benefits tumors in other ways. For instance, the production of lactic acid as a byproduct helps tumor cells penetrate neighboring tissues or even spread (metastasize). Scientists at the University of Arizona have found that culturing cancer cell lines in even a slightly acidic medium “caused dramatic increases in both migration and invasion” (Martinez-Zaguilan 1996). The cells became more cancerous.  
 
Pedersen Arrives at Hopkins  
 
Peter Pedersen began his career as a postdoctoral fellow in the Department of Biological Chemistry of Johns Hopkins Medical School (ranked the nation’s top medical school for research). He had the good fortune to work under Albert L. Lehninger, PhD, a legendary figure in biochemistry and author of Principles of Biochemistry (now in its 9th edition). After completing postdoctoral work in Lehninger’s laboratory, Pedersen focused on understanding how mitochondria make ATP, the major energy source for all cellular–energy requiring processes. As a new faculty member, he then set out two long-term goals related to the study of cancer:  

1. 
   to explain at a cellular and molecular level the “Warburg effect”; i.e., increased metabolism of glucose to lactic acid even in the presence of oxygen. (That is, even though the mitochondria of cancer cells are capable of making sufficient ATP to fuel/power their growth via OxPhos, such cells also make significant use of glycolysis to help make this ATP.)  
    
   2. to discover a drug that inhibits both of cancer’s energy-producing factories, OxPhos and glycolysis, while leaving normal cells alone. Then, without their source of energy, the cancer cells that comprise tumors will die quickly and the tumors will disappear.  
    
   Needless to say, while goal #1 would be a major advance for science, goal #2 would be an even greater advance for humanity. We are, after all, talking about finding an effective and minimally toxic treatment for almost all cancers! For the next almost four decades, Pedersen and his coworkers struggled with this, among other problems.  
    
   A String of Discoveries  
    
   Along the way, Pedersen and his coworkers made at least a dozen major discoveries in the field of cancer metabolism. Without going into great detail (all of which is available in the standard medical literature), I will sketch the outlines of several below.  
    
   1970: Pedersen and his group discovered that cancers exhibiting the Warburg effect have a reduced respiration rate relative to their tissue of origin. However, this reduced respiration rate is not due to defective mitochondria but to a markedly reduced number of mitochondria (Schreiber et al. 1970).  
    
   1977: The Warburg effect mainly results from a less commonly used variant (called an isoform) of the enzyme hexokinase, which is markedly elevated in cancer and binds to the outer membrane of the mitochondria (Bustamante and Pedersen 1977).  
    
   1984: In cancer cells that exhibit the Warburg effect, there is a division of labor in producing the required energy. This central task is shared by two energy-producing factories: OxPhos and glycolysis. In some liver cancer cells, for example, about 60% of the energy comes from glycolysis and 40% from OxPhos in the mitochondria (Nakashima et al. 1984). This is a major point, as many people believe that cancer cells are fueled exclusively by glycolysis. However, malignant cells actually use both methods. Thus any agent that is postulated to cut the energy supply of a tumor must eradicate both energy-producing factories while leaving normal cells unharmed.  
    
   1988: The form of hexokinase (an enzyme) that is involved in the Warburg effect is hexokinase 2 (Hk-2; Nakashima et at. 1988). Other scientists later discovered that Hk-2 is bound to the outer mitochondrial membrane, where it renders cancer cells immortal.  
    
   2001: Now we come to the most important of all the discoveries in Pedersen’s lab. This was the finding, made by his colleague Ko, that in cancer cells a small molecule called 3-bromopyruvate (3BP) inhibits both glycolysis and OxPhos (Ko et at. 2001). This fulfills the second task that Pedersen set himself to accomplish in the 1960s.  
    
   Ko was born in South Korea. She completed her master’s degree in nutritional physiology at Iowa State University and graduate school in biochemistry/biophysics at Washington State University. In the 1990s she came to Johns Hopkins as a postdoctoral fellow. She and Pedersen have been working together since 1991 (Thomas 1992).  
    
   Asked by Pedersen to find a drug that would target both types of energy production, Ko thought of a substance that she had worked with as a graduate student. This was 3BP. In our conversation, Young referred to 3BP as a kind of “Trojan horse,” which tricks the cancer cell into thinking that it is receiving a useful nutrient, when in fact it is receiving a powerful cancer-killing molecule.  
    
   Given 3BP, as specially formulated by Ko, tumor cells are quickly destroyed, while normal cells are left unaffected. This is because, unlike tumor cells, normal cells do not have elevated levels of monocarboxylic acid transporters (MCTs). As Ko and Pedersen explained it, MCTs are the transporters that allow 3BP to get inside tumor cells. Once inside, 3BP quickly destroys both of the tumor cells’ power plants (glycolysis and OxPhos). The tumor cells die quickly via either apoptosis or necrosis (two common methods of cell death), attended by a rapid depletion of their energy.  
    
   2004: Ko and Pedersen, with half a dozen coauthors, published the first account showing that 3BP is able to completely destroy tumors in all animals tested, without causing noticeable toxicity. The tested animals lived out their normal lifespans without the cancerous tumors reappearing (Ko et al. 2004). Pedersen says that, to his knowledge, this was the first time in history that a small molecule was shown to have such remarkable cancer-curative effects.  
    
   2002: At around the same time, Ko and colleagues also participated in a study that showed that the intra-arterial delivery of 3BP formulated by Ko prevented cancer metastases (spreading) from the liver to the lungs (Geschwind, Ko, et al. 2002) and likely to other tissues as well. These are remarkable findings, unprecedented in cancer research. Prominent scientists have spent lifetimes in trying to discover agents with only a small fraction of the potential in this molecule. The significance of this finding cannot be overstated, since it is well known that most deaths from cancer result from its metastasizing to other organs, and not from the primary growth.  
    
   2012: Ko showed that 3BP can work in humans. In a recent paper, 3BP was tested successfully in a few people, with no obvious signs of toxicity. One young teenage patient from Europe, who had been sent home to die by his doctors, lived for another year after taking 3BP. He even was able to take a vacation to the US with his parents, where he participated in a clinical lecture at Johns Hopkins. His death was not due to the primary cancer, Ko told me, but to an infection (Ko et al. 2012).  
    
   The authors also showed that 3BP was capable of stimulating liver regeneration after first killing the primary liver tumor. This is believed to be the first time that a chemical agent was able to have such an organ-regenerating effect (Ko et al. 2012)  
    
   2013: In January, the Nobel laureate James D. Watson, PhD, codiscoverer of DNA’s “double helix” and the most renowned scientist in the world today, paid homage to 3BP and, by extension, to the work of Pedersen and Ko. He wrote:  

3-bromopyruvate, the powerful dual inhibitor of hexokinase as well as 

  oxidative phosphorylation, kills highly dangerous hepatocellular 

  carcinoma [liver cancer], cells more than 10 times faster than the 

 more resilient normal liver cells and so has the capacity to truly 

 cure, at least in rats, an otherwise highly incurable cancer. 

 
 
In his paper Watson referenced the 2004 Ko et al. manuscript.  
 
Pedersen’s career in biological chemistry essentially began in 1961 when he gave a seminar on the discoveries of James Watson and Francis Crick about the double-helical structure of DNA as one of his last requirements as an undergraduate chemistry major at the University of Tulsa. How ironic, then, that 50 years later Prof. Watson returned the compliment, and publicly paid homage to Pedersen and Ko’s work with 3BP. As Pedersen put it, “Perhaps it is fair to say that he or she who follows in the footsteps of other great scientists may one day have them following in their own footsteps.”  
 
2013: Prof. David M. Sabatini, a member of the Whitehead Institute of Biomedical Research (Cambridge, MA), and his colleagues recently confirmed Pedersen and Ko’s work with 3BP. Interestingly, but importantly, they made their confirmation without corresponding with either Pedersen or Ko before publishing their confirmatory paper (Birsoy 2013).   Sabatini and colleagues wrote:  

  Our results identify a potential biomarker for 3-BrPA [another 

 abbreviation for 3BP] sensitivity and provide proof of concept that 

  the selectivity of cancer-expressed transporters can be exploited for 

  delivering toxic molecules to tumors. (ibid.) 

 
Scientists would understand that the “toxic molecule” in question, 3BP, is only “toxic” in relation to cancer cells. Normal cells are spared as they have fewer transporters capable of moving 3BP into the cells.  
 
Conclusions  
 
Readers will of course be happy to hear that such a promising new agent as 3BP has emerged from Johns Hopkins School of Medicine and has been confirmed by scientists at other institutions, such as the Whitehead Institute. 3BP is not only important in its own right but serves as “proof of principle” for the idea that one can manipulate metabolism to interfere with the growth of cancer. Pedersen believes in metabolic therapy and wrote the introduction to Thomas Seyfried’s provocative recent book, Cancer As A Metabolic Disease.  
 
On the other hand, there is a dark side to this story. First, after nearly a decade, 3BP remains unavailable to cancer patients. It is not even in formal clinical trials in the US. Perhaps even more outrageous still is that NIH study sections assigned to review two of Pedersen’s cancer-related renewal applications in recent years have rejected them several times. The few (2 or 3) peer reviewers assigned to look at each of their assigned applications have the power early on in meetings at the NIH (or some location nearby) to recommend its rejection. Once this is recommended, the application is thrown in the trash without a formal review; that is, a discussion involving not only the two or three assigned reviewers but the entire study section (15 to 30 scientists). This is simply an outrage, not only to the public at large but to those study section members who never had the opportunity to really read and discuss fully the applications.  
 
Perhaps an “angel” will appear to fund further necessary research into the remarkable activity of this substance. Or perhaps the issue will need to be slugged out in newspapers and websites, or in the halls of Congress, as has happened before in the history of cancer. However it happens, 3BP deserves further study and fair, honest, and thorough clinical trials so we can finally learn more about its potential as a simple, nontoxic or surely less toxic treatment for cancer.  
 
Finally, it should be noted that Dr. Pedersen sent a personal letter to President Obama about this matter on January 22, 2013. The president’s mother died of ovarian cancer at the early age of 53. Months later, Dr. Pedersen had still received no response from the president. If the federal government is seriously interested in ending the scourge of cancer it should pay attention to the exciting things that are happening in Baltimore. SOURCE: Cancer Decisions – July 2013 
 
References: 
 
Birsoy K, Wang T, Possemato R, et at. MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nat Genet. 2013; 45 (1): 104-108.  
 
Bustamante E, Pedersen PL. High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Nat! Acad Sci USA. 1977; 74 (9): 3735-3739.  
 
Geschwind J-FH, Ko YH, Torbenson MS, Magee C. Pedersen PL. Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. Cancer Res. 2002; 62(14): 3909-391 3.  
 
Ko YH, Pedersen PL, Geschwind JF. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett. 2001; 173 (1): 83-91.  
 
Ko YH, Smith BL, Wang V. et al. Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochem Biophys Res Commun. 2004; 324 (1): 269-275.  
 
Ko YH, Verhoeven HA, Lee MJ, et al. A translational study “case report” on the small molecule “energy blocker 3-bromopyruvate (3BP) as a potent anticancer agent; from bench side to bedside. I Bioenerg Biomembr. 2012; 44 (1): 163-170.  
 
Nelson DL, Cox MM. Lehninger Principles of Biochemistry. 5th ed. New York: W.H. Freeman; 2008: 539.  
 
Martinez-Zaguilan R, Seftor EA, Seftor RE, et al. Acidic pH enhances the invasive behavior of human melanoma cells. Clin Exp Metastasis. 1996; 14 (2): 176-186.  
 
Nakashima RA, Paggi MG, Scott LJ, Pedersen PL. Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line. Cancer Res. 1988; 48 (4): 913-919.  
 
Schreiber JR, Balcavage WX, Morris HP, Pedersen PL. Enzymatic and spectral analysis of cytochrome oxidase in adult and fetal rat liver and Morris hepatoma 3924A. Cancer Res. 1970; 30 (10): 2497-2501.  
 
Thomas PJ, Ko YH, Pedersen PL. Altered protein folding may be the molecular basis of most cases of cystic fibrosis. FEBS Lett. 1992; 312 (1): 7-9.  
 
Watson J. Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol. 2013; 3 (1): 120144. 

The bark of the Amur cork tree (Phellodendron amurense) has traveled a centuries-long road with the healing arts. Now it is being put through its paces by science in the fight against pancreatic cancer, with the potential to make inroads against several more. 

UT Health Science Center researcher A. Pratap Kumar was already exploring the cork tree extract’s promise in treating prostate cancer when his team found that deadly pancreatic cancers share some similar development pathways with prostate tumors. 

In a paper published in the journal Clinical Cancer Research, the researchers show that the extract blocks those pathways and inhibits the scarring that thwarts anti-cancer drugs. Dr. Jingjing Gong, currently pursuing post-doctoral studies at Yale University, conducted the study as a graduate student in Dr Kumar’s laboratory in the Department of Pharmacology. 

“Fibrosis is a process of uncontrolled scarring around the tumor gland,” said Dr. Kumar, a professor of urology in the School of Medicine at the Health Science Center and the study’s principal investigator. “Once you have fibrotic tissue, the drugs cannot get into the cancer.” 

Liver and kidney tumors also develop fibrosis and the resulting resistance to drugs, he said, and there are no drugs currently targeting that pathway in those cancers. 

The two pathways, or proteins, that contribute to fibrosis in those tumors also encourage Cox-2, an enzyme that causes inflammation, and the cork tree extract appears to suppress that as well, Dr. Kumar said. The complex interrelationship of these substances is “the million-dollar question,” he said, and solving that question is one of the next steps in his research. 

The potential of natural substances to treat and cure disease has great appeal, but the advantage of cork tree extract, available as a dietary supplement in capsule form, is that it already has been established as safe for use in patients. In a promising prostate cancer clinical study of 22 patients that Dr. Kumar helped spearhead, all the patients tolerated the treatment well, he said. Now researchers are analyzing the results, he said, and with more funding they plan to expand the study to a much larger group of patients. 

The dietary supplement is marketed as Nexrutine by Next Pharmaceuticals of Salinas, Calif., which provided a supply of the compound for the studies. Source: University of Texas Health Science Center at San Antonio – BIOScience Technology – March 3, 2014 

WE believe that it might be possible to treat breast cancer — the leading cause of female cancer death — with a drug that can already be found in nearly every medicine cabinet in the world: Aspirin. 

In 2010, we published an observational study in The Journal of Clinical Oncology showing that women with breast cancer who took aspirin at least once a week for various reasons were 50 percent less likely to die of breast cancer. In 2012, British researchers, by combining results from clinical trials that looked at using aspirin to prevent heart disease, found that aspirin was also associated with a significantly lower risk of breast cancer death. 

And yet, until now, there have been no randomized trials (the gold standard of research) of aspirin use among women with breast cancer. 

It’s not hard to see why: Clinical trials are typically conducted on drugs developed by labs seeking huge profits. No one stands to make money off aspirin, which has been a generic drug since the Treaty of Versailles in 1919, and which costs less than $6 for a year’s supply. 

Thankfully, the first randomized clinical trial is now going on in Britain, made possible by funding from a nonprofit group, Cancer Research UK. But the British study is looking at four cancers, and won’t be done until 2025. If we in the United States had funding to do a similar trial, we could combine our data and get answers much faster. If the United States is to maintain its role as the global leader in biomedical research, it must fund its own trial of aspirin in breast cancer. 

Aspirin was originally derived from willow bark, which has been used as a painkiller since the time of Hippocrates. We don’t know exactly why it appears to work in fighting cancer. Aspirin reduces inflammation, and that may play a role in inhibiting the growth of tumors — perhaps by slowing the development of new blood vessels that nourish them, or by fighting old cells that keep growing when they should be dying off. It may also inhibit estrogen production, and we know that estrogen fuels the growth of most (but not all) breast cancers. 

If we could prove that aspirin was an effective treatment in a clinical trial, it would have major implications, especially for low-income patients. Modern hormonal treatments, used after surgery to try to prevent cancer from recurring, last a standard five years and can cost between $1,200 and $2,300 a year. But not everyone who needs them is actually taking them. Higher co-pays reduce the number of women who fill their prescriptions, according to a 2011 study. 

And that is just in the United States. Africa, Asia and Central and South America already account for more than 60 percent of the world’s cancer cases and about 70 percent of cancer deaths, according to the World Health Organization. The majority of the impact of the disease will be felt in those areas in the coming decades. Aspirin’s minimal cost would make it available in every country on earth, and for millions of women it could mean the difference between some treatment and none. 

It may also offer an alternative treatment to women who cannot tolerate widely used cancer drugs because of debilitating side effects. For example, Columbia University researchers found that half of breast cancer patients taking hormonal treatments (specifically, tamoxifen and aromatase inhibitors) were unable to take the drugs for the recommended five years. A survey by the advocacy group Breast Cancer Action found that the predominant reason was joint pain. The most serious possible side effects of taking aspirin are gastrointestinal bleeding and stroke, but they are rare. 

If aspirin truly works, we estimate that we could save 10,000 lives per year in the United States, and 75,000 in the developing world. 

It won’t take much to find out. A randomized study of approximately 3,000 women with Stage 2 and 3 breast cancer, lasting five years, would cost around $10 million. (We wouldn’t study women with Stage 1 disease because they have such a high survival rate already, nor women with Stage 4 cancer, because there is not enough evidence that aspirin would help when the disease has advanced that far.) 

Although $10 million is a relatively small amount for a large pharmaceutical company, it is too big for most federal grant mechanisms and nonprofit foundations. Our repeated attempts since 2010 to seek funding through federal grant mechanisms have been rejected. 

Yet even as government funding for research is slashed, the government is still willing to test new cancer drugs pushed by pharmaceutical companies, despite very high failure rates for those drugs. Federal grant review panels have no direct financial interest in the studies they approve for funding, but inevitably they are seduced by the more novel treatments — the scientific equivalent of the latest smartphone. And generic drugs, particularly ones as old and familiar as aspirin, just aren’t sexy. 

There’s a saying attributed to Hippocrates that extreme remedies are appropriate for extreme diseases. But in the case of breast cancer, the most simple of drugs may be the next great weapon. SOURCE: New York Times – May 19, 2014 

The nanomedicine (red) with the optimal size shows the highest tumor tissue (blue) retention integrated over time, which is the collective outcome of deep tumor tissue penetration, efficient cancer cell internalization as well as slow tumor clearance. 

Nanomedicines consisting of nanoparticles for targeted drug delivery to specific tissues and cells offer new solutions for cancer diagnosis and therapy. Understanding the interdependency of physiochemical properties of nanomedicines, in correlation to their biological responses and functions, is crucial for their further development of as cancer-fighters. 

“To develop next generation nanomedicines with superior anti-cancer attributes, we must understand the correlation between their physicochemical properties — specifically, particle size — and their interactions with biological systems,” explains Jianjun Cheng, an associate professor of materials science and engineering at the University of Illinois at Urbana-Champaign.  

In a recent study, published in the Proceedings of the National Academy of Sciences, Cheng and his collaborators systematically evaluated the size-dependent biological profiles of three monodisperse drug-silica nanoconjugates at 20, 50 and 200 nm. 

“There has been a major push recently in the field to miniaturize nanoparticle size using novel chemistry and engineering design,” Cheng added. “While most current approved anti-cancer nanomedicines’ sizes range from 100-200 nm, recent studies showed that anti-cancer nanomedicines with smaller sizes — specifically of 50 nm or smaller — exhibited enhanced performance in vivo, such as greater tissue penetration and enhanced tumor inhibition.” 

“Over the last 2-3 decades, consensus has been reached that particle size plays a pivotal role in determining their biodistribution, tumor penetration, cellular internalization, clearance from blood plasma and tissues, as well as excretion from the body — all of which impact the overall therapeutic efficacy against cancers,” stated Li Tang, first author of this PNAS article. “Our studies show clear evidence that there is an optimal particle size for anti-cancer nanomedicines, resulting in the highest tumor retention. 

Among the three nanoconjugates investigated, the 50 nm particle size provided the optimal combination of deep tumor tissue penetration, efficient cancer cell internalization, as well as slow tumor clearance, exhibits the highest efficacy against both primary and metastatic tumors in vivo. 

To further develop insight into the size dependency of nanomedicines in tumor accumulation and retention, the researchers developed a mathematical model of the spatio-temporal distribution of nanoparticles within a spherically symmetric tumor. The results are extremely important to guide the future research in designing new nanomedicines for cancer treatment, Cheng noted. In addition, a new nanomedicine developed by the Illinois researchers — with precisely engineered size at the optimal size range — effectively inhibited a human breast cancer and prevented metastasis in animals, showing promise for the treatment of a variety of cancers in humans. 

Cheng, a Willett Faculty Scholar at Illinois, is affiliated with the departments of Bioengineering and of Chemistry, the Beckman Institute for Advanced Science and Technology, the Micro and Nanotechnology Laboratory, the Institute of Genomic Biology, the Frederick Seitz Materials Research Laboratory, and University of Illinois Cancer Center. 

Tang, who obtained his PhD degree from the University of Illinois with Jianjun Cheng, is currently a CRI Irvington postdoctoral fellow at the Massachusetts Institute of Technology. Collaborators and co-corresponding authors of the paper at Illinois include Timothy Fan, associate professor, veterinary clinical medicine; Andrew Ferguson, assistant professor, materials science and engineering; and William Helferich, professor, food science and human nutrition. SOURCE: Science Daily – University of Illinois College of Engineering – October 16, 2014 

Journal Reference: 

1. L. Tang, X. Yang, Q. Yin, K. Cai, H. Wang, I. Chaudhury, C. Yao, Q. Zhou, M. Kwon, J. A. Hartman, I. T. Dobrucki, L. W. Dobrucki, L. B. Borst, S. Lezmi, W. G. Helferich, A. L. Ferguson, T. M. Fan, J. Cheng. Investigating the optimal size of anticancer nanomedicine. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1411499111  

Today I’d like to answer multiple questions sent to me regarding last week’s issue, in which I discussed the supplements that Mr. Mauldin and I are taking. By way of explanation, I didn’t include links to the actual products I discussed for the simple reason that I don’t want to give the impression that we’re recommending these products for financial reasons. 

I think that most people know it’s possible today for vendors to track where links come from. Some organizations give the linkers a cut of their revenues. Amazon.com does this through its affiliate program, but we’re not doing that. 

Personally, it always sort of irritates me when organizations appear to be hawking supplements because it makes me question their objectivity; so I didn’t include links. I’ve been convinced to do otherwise, however, in the explanations below. Let me clarify that we have no financial arrangement with anyone regarding these supplements. I write about them, and take them, based solely on the emerging science. Before you take anything yourself, you should always review the latest literature and speak with your physician. 

My interest is driven not just by a desire to be as healthy as possible, by the way; I’m also convinced that breakthroughs in biotech analytical tools are making it possible to find rather simple compounds that will have large impacts on health and demographics. Since demographic change is having an enormous impact on our economy and politics, we should be interested in anything with the potential to significantly increase healthspans and alter the makeup of the population. 

Since we’re talking about supplements, I should start with the most misunderstood: vitamin D. Everybody takes some. What has changed recently, however, is the consensus regarding optimal dosages. In fact, you can’t really say how much vitamin D you should take. It’s your 25-hydroxyvitamin D blood level that really matters. Different individuals will need very different doses of oral vitamin D to accomplish the target range recommended by the top researchers in this field, which is 40-60 ng/mL. 

I realize, by the way, that there are still some people in government science organizations that disagree with me. If you think about virtually any area of nutrition in which government has given guidelines over the past 50 years, there is a near 100 percent record of getting it wrong. Rather than go over the new research again, let me direct you to the University of California project dedicated to increasing understanding about D. It’s GrassrootsHealth, which you can access at this link. 

The thing I really like about this organization is that they offer a test for D levels, which is inexpensive compared to the cost of the average lab test. A superior solution is to find a doctor, like mine, who keeps up with the literature and prescribes a full blood workup regularly. I’m about two weeks late for my blood work now, by the way, but I’ve been overwhelmed of late. 

If you monitor the flood of new studies being published about vitamin D, it’s hard not to come to the conclusion that a program of societal supplementation would extend average healthspans enough to solve most of our healthcare budget problems. This assumes, of course, that people continued working and investing through the years of added health. If, however, they decided to use the extra years collecting retirement benefits, it would exacerbate the already enormous problem of unfunded entitlements for the aged, which is the main driver behind the debt crisis. 

Whenever anybody asks me about supplements, my standard answer is to take vitamin D3 before you worry about anything else. Dr. Michael Holick, who pioneered the new research on vitamin D, suggests that about 4,000 units a day will get most but not all healthy people up to about 40 ng/mL. My blood levels are typically closer to 60 ng/mL, but I live in South Florida and spend a little time in the sun most days. 

If you live farther north, however, the sun may not provide much help for much of the year. UVB is missing for most of the day in northern latitudes but is required for D synthesis. Sunshine has benefits other than vitamin synthesis, though. A Scottish study showed that people with greater but not extreme exposure to sunshine had statistically significantly lower blood pressure even when there was no ultraviolet B (UVB) present. This is apparently due to increased production of nitric oxide. 

When I got my D levels up where they should be about seven or eight years ago, the impact on my health was immediate and palpable. You can get D3 from Amazon.com here, but I take whatever brand my nutritional biologist wife happens to pick up at Walmart. I don’t worry about brands and have taken many. I know my serum blood levels are where I want them to be, so all the major brands seem to have worked. 

Last week, I concentrated on nicotinamide adenine dinucleotide plus (NAD+) precursors, based on the huge amount of research coming out now about this emerging area of science. Nicotinamide riboside (NR) is getting the most attention. Not only has NR been endorsed recently by several famous scientists, the first human studies showed that a single dose raises NAD+ levels. 

ChromaDex is the only supplier of nicotinamide riboside, a natural substance found in milk, as it owns the usage and manufacturing patents. It is brand-named Niagen, but ChromaDex does not sell the product directly. It’s available through Amazon.com and elsewhere. John and I take the High Performance Nutrition brand in the black and blue bottle. 

Incidentally, the ChromaDex scientific advisory board is chaired by Nobel laureate Roger Kornberg, a Professor at Stanford Medical School. His Nobel prize in Chemistry in 2006 was for research on the molecular basis of eukaryotic transcription, which my son and I discuss around the dinner table occasionally. When Kornberg accepted the role as chair of the SAB, he specifically cited his interest in NR due to his father’s research. 

Kornberg’s father was also a Nobel prize winner. A professor of biochemistry at Stanford, the late Arthur Kornberg won the prize for physiology or medicine in 1959 and pioneered nicotinamide riboside research while at the NIH. 

“Given my father’s noteworthy early research of nicotinamide riboside,” the younger Kornberg said, “I have been following ChromaDex’s progress on developing its Niagen nicotinamide riboside as well as the enormous amount of published research that speaks to the health benefits of NR.” 

The MIT recipe referenced here includes another ChromaDex product, pterostilbene, which occurs naturally in blueberry skin. John and I have been taking both of these molecules for several years now. It’s available under the trade-name pTeroPure from several sources, including Amazon.com. Though others sell pterostilbene, I don’t trust other brands that don’t use the ChromaDex product. 

Another NAD+ precursor that we’ve both taken for several years is oxaloacetate. As is the case with NR, there is only one supplier which owns usage and manufacturing patents on the heat-stabilized version currently being used by universities researching efficacy in the treatment of neurodegenerative diseases. The company, of course, makes no medical claims as that would bring various government agencies down on its head like granite slabs dropped from helicopters. Free speech? Regardless, it’s trade-named benaGene, which you can also get through Amazon.com, but we get it from the manufacturer here. 

Oxaloacetate is a naturally occurring molecule that plays a critical role in the citric acid cycle and other cellular functions. It increases NAD+ through an entirely different mechanism of action than NR’s, so we take them both. It may not be necessary but it will be years before definitive information is generated. 

We also take acetyl-L-carnitine because it has been shown in animal studies to work synergistically with oxaloacetate. My wife and doctor have both recommended L-carnitine for a while, but it was this study showing complete restoration of long-term potentiation (LPT) in rats with cerebral ischemia, or stroke, that made me start taking it assiduously. 

Long-term potentiation (LPT) refers to the ability of brain synapses to increase signal transmission based on repeated activity. In other words, the study shows that oxaloacetate and L-carnitine completely restored the ability to learn in rats suffering from induced stroke. This seems like a very good sign to me, since LPT tends to decrease with age in humans. Given the option, I’d like to preserve the ability to learn as long as possible. Maybe, someday, I’ll even learn how to spell “rhythm” without a spell checker and remember my in-laws’ names. 

Anecdotally, a lot of people who use either NR or oxaloacetate report a lifting of mental “fogginess.” Dave Asprey, better known as the Bulletproof Executive, sells a coffee with oxaloacetate for that purpose. I don’t know, by the way, if his product is cost-effective. I haven’t looked that closely at his materials. Coffee on its own, by the way, is incredibly healthful for most people unless they let it interfere with sleep. I’ll spend one paragraph on coffee before returning to acetyl-L-carnitine and oxaloacetate. 

I’ve gone into the literature on the subject of coffee and caffeine innumerable times but it’s solid science. In previous articles, I’ve linked to this special issue of the Journal of Alzheimer’s Disease that categorized coffee as “disease-modifying” for AD. Editor Dr. Mark Smith, one of the world’s leading Alzheimer’s researchers before his accidental death a few years ago, was so enthusiastic about coffee as therapy that he made the issue free to download. In terms of cost-effectiveness, coffee has got to rank alongside vitamin D in efficacy. 

Returning to the subject of acetyl-L-carnitine, this naturally occurring substance breaks down in the blood to transport fatty acids into the mitochondria for conversion to adenosine triphosphate (ATP), which is the only form of energy our bodies can utilize. Acetyl-L-carnitine seems to be particularly important for those who exercise strenuously. 

It’s certainly possible that the same repair of long-term potentiation observed in rats will take place in humans. Anyway, acetyl-L-carnitine is generally considered beneficial on its own, as is oxaloacetate, so there doesn’t seem to be much downside to supplementation with both while the upside is potentially dramatic. 

Another supplement related to ATP energy production that we take is ubiquinol, a somewhat new and reduced (as opposed to oxidized) form of coenzyme Q10 (CoQ10) that appears to be more active. Ubiquinol is a critical part of the electron transport chain, transferring electrons in the process of synthesizing ATP. It’s also available through Amazon.com, as is acetyl-L-carnitine, though my wife buys them both at Walmart, I think. 

Then, of course, John and I are both using up the last of our anatabine citrate, which is no longer commercially available. I assume, however, that someone is hunting for another NF kappa B moderator. There’s an awful lot of unstudied alkaloids out there, and some very smart people know about the unprecedented data generated in the animal and human anatabine trials. Rock Creek Pharmaceuticals is miles ahead on the drug development path as they have permission to begin human trials for arthritis in the UK, but someone else may go after the supplement market. 

Hopefully, this answers all the questions I received. This isn’t a complete list of the supplements that John and I take, but I think it covers the most important and least known. Let me reiterate once more that we have no financial arrangements with the manufacturers of any of these products. 

My hope is you find the above discussion of supplements and the emerging science behind them compelling, and can begin your own research with the data I’ve provided. SOURCE: Transformational Technologies – February 20, 2015 

The Survival Triangle 

I call my three pillars to beat cancer the “survival triangle.” If you’re serious about keeping (or getting) cancer out of your life, follow these steps to better health. They are simple, proven fighters that will make you a winner against this devastating disease. Taking a single one and making it part of your life will make a huge difference in your overall health. 

If you utilize all three, it will change your life. 

Now, before anything, let me say that traditional cancer treatment (surgery, chemotherapy, and radiation) does its part to help patients survive cancer. 

Unfortunately, they don’t address the root cause of cancer. They treat the tumors that result. They kill the cancer cells and a lot of healthy cells along the way. Conventional cancer modalities treat the disease…not the patient. 

Even oncologists who understand that toxins and inflammation are the underlying cause of millions of deaths globally from cancer every year aren’t addressing prevention techniques that will keep these patients from coming back with another cancer in a year or five years. 

Addressing the “Alternative Medicine Skeptics” 

If you don’t address the cause – the problems that start the cancer ball rolling – then you haven’t really beaten it…you’ve only managed to knock it unconscious for a while. 

You have to take control of your health. That requires you to understand how your body works and what it needs to do the best job for you that it can. 

If you don’t “believe” in alternative therapies, then you’re doing yourself a great disservice. Even if you fully expect traditional treatment to “cure you,” alternative methods can help you with the side effects you’re going to experience, keep your body stronger, and guard you against another episode of cancer in your future. 

Alternative choices can improve your quality of life and help you endure treatments such as radiation that leave the body (and immune system) ravaged and weak. The “war” against cancer leaves as much destruction as a real war. Much like the natural landscape and infrastructure is left annihilated in battle – so is your body after traditional treatment. 

Pillar #1 – DIET 

Cancer represents the biggest fight of your entire life.  You need to be as fit and healthy as you can be to meet the challenge. In order to handle the demands of exercise, to terminate infection and bacteria, to fight the effects of age, your body is going to need the right fuel. 

That is why diet is the first pillar of beating the root causes of cancer. 

Anyone (medical professional or otherwise) who tells you that diet does not affect your health or ability to fight disease is a liar. Period. 

Diet is everything. Even the World Health Organization (WHO) estimates that around 40% of cancers are caused by diet (I think the numbers are actually much higher). What you choose to put in your mouth may mean the difference between life and death. 

That isn’t dramatic, that is fact. 

Eating a diet filled with junk food, dyes, preservatives, excess sugar, caffeine, or other “empty” calories cannot and will not feed your body. If your body doesn’t get the right vitamins and minerals – it stops running. Just like a car without gas. 

There are many anti-cancer meal plans that I discuss in my books and on Alternative-Doctor.com but there is no universal diet plan that will suit every person equally. Instead, dietary requirements must be assessed based on each individual’s specific needs. Remove any foods (no matter how much you love them) that cause stress to your immune system. 

My personal suggestion is to fill your diet with fresh, organic foods (where possible), salads, smoothies, and brightly colored produce. Remember that dairy, soy, grains, and even certain produce can be unknown stressors. Avoid white sugar, white flour, white rice, processed foods, dairy, and soy. 

Pillar #2 – Emotional Cleansing 

Negative emotion as a root cause of cancer is reality. There is far too much science to back this stance up, so keep an open mind. 

Stanford psychiatrist, Dr. David Spiegel, was a skeptic when he began his study on the influence of negativity on breast cancer patients. He was shocked to discover that at the ten-year survival checkup, those women who included therapy in their lives survived twice as long as those who did not. 

You read that right…there was a 50% better survival rate by purging negative emotion. 

Another Yale research study found that cancer spread faster in women who had “repressed personalities.” They defined the word “repressed” as having intense feelings of hopelessness and not having the ability to express anger, fear, or other negative emotions. 

In other words, they bottled it all up inside and it made them sicker, faster. 

Stress is known in the traditional and alternative communities as a major cause of inflammation. It is one thing everyone agrees on (though traditional medicine’s answer is another prescription). Inflammation has been discovered at the base of all known diseases. 

In other words, stress will kill you through cancer or heart attack or autoimmune disease…if you allow it to control your life. Balanced emotions equal a balanced physiological system. 

Pillar #3 – DETOXIFICATION 

There are countless stressors in our modern world and many of them are foods, people or situations, and products we allow into our lives. We’ve talked about the first two. Let’s discuss the contamination most people never consider. 

Personal pollution is as dire as environmental pollution and we are surrounded by both at every turn. Pollutants are in our soil, water, and air and that means they are in our food supply. Those are harder to control (even organic foods are grown on the same planet we’ve corrupted with countless toxins). 

You can control what you put on your body, what you put in your body, and how you maintain the environments you live in most (your home and work space). 

If you haven’t heard about the chemical soup found in cosmetics, household goods, and everyday cleansers, I urge you to do some research on it right now. From heavy metals and arsenic to formaldehyde and parabens…products you buy every day at your local market are filled with endocrine disruptors, estrogen mimics, and outright poison to the cells in your body. 

One person I urge you to read is Dr. Sam Epstein, a professor of Occupational Health and Environmental Medicine at the University of Illinois School of Public Health. 

In his book, The Politics of Cancer, he states, “The NCI (National Cancer Institute) promised annual cancer mortality rates would be halved by the year 2000. The establishment now belatedly admits that cancer rates are increasing sharply. It discounts substantial evidence…the wide range of chemical and radioactive carcinogens permeating the environment, air, water, food, and the workplace. The establishment ignores, let alone investigates, carcinogenic contaminants in dietary fat, particularly pesticides, PCBs, and estrogen (with extensive and unregulated use as growth promoting animals food additives).” 

Big Business (food manufacturers, chemical producers, and even personal care manufacturers), and Big Pharma (drugs, drugs, drugs) don’t care about your health. They don’t care about “curing” anything at all because then…how would they make money? 

Every time you use cosmetics, shampoos, conditioners, antiperspirants, paints, household cleaning agents, laundry detergent, or any host of other products…you are playing Russian Roulette with your health. 

These deadly toxins don’t just pass through your system. No, that would be bad but your (healthy) immune system would be able to control most of the fallout. What makes many of these chemicals so dangerous is that they accumulate in your body, gradually building up (bit by bit) to levels that are toxic according to any agency. 

The True Causes of Cancer 

There are many things stressing your body each and every day. Junk nutrition, high levels of stress, and chemical contamination push these stressors past the brink of what your body can handle. SOURCE: The Truth About Cancer – Dr. Keith Scott-Mumby – July 11, 2015 

“I’ve been in cancer study for 20 years, and I’ve never seen anything like this, that just melts tumors away.” 

That was the view of Martin G Pomper, M.D., Ph.D., professor of radiology at Johns Hopkins School of Medicine. 

He said this back in 2004. 

What got him so excited, and why have we heard nothing about this remedy since? Read on to find out. 

The metabolic theory of cancer 

Initially produced in the 1940s, an off-the-shelf molecule called 3-bromopyruvate (3-BP) had been all but forgotten until it came to the attention of Young Hee Ko, Ph.D., a medical researcher at Johns Hopkins. 

It turned out to have special properties that made it ideal as an anti-cancer agent. 

But before we look at why she was interested in this chemical, we need to take a look at the lab she joined. 

It was headed by professor of biological chemistry and oncology, Peter L Pedersen, Ph.D. His research focused on cell energetics. Dr. Pedersen was a disciple of Nobel winning scientist Otto Warburg. 

According to Dr. Warburg, normal, healthy cells produce 95% of their energy aerobically (with oxygen) via the mitochondria, the cell’s “batteries.” But cancer cells are different. They produce up to 60% of their energy anaerobically (without oxygen) by breaking down glucose. 

This is a very inefficient, primitive way of generating energy, and – what’s worse — it produces lactic acid as a toxic byproduct. This is known as the Warburg Effect. It’s found in more than nine out of ten cancers. 

He believed a dysfunction in the mitochondria caused this switch in the way energy is produced and was the prime cause of cancer. 

Dr. Pedersen’s work focused on the mitochondria and documented the Warburg Effect in detail. He took his work further, noting the vastly reduced number of mitochondria in cancer cells and the structural abnormalities of the ones that remain. It seems like cancer cells have no option but to revert to a primitive form of generating energy. 

Most current cancer research focuses on genetic mutations. It’s become more or less medical doctrine that these mutations are the cause of cancer. In sharp contrast, the work of Dr. Pedersen and others is advancing a competing theory: The metabolic origin of cancer, which theorizes that cancer originates in mitochondrial damage, possibly caused by free radicals and toxicity. 

This damage disrupts the signaling that takes place between these energy centers and only then does the nucleus – the DNA — get disrupted. This leads to changes in gene expression and mutations. 

Dr. Pedersen and other like-minded scientists believe that gene mutations are an effect and not the underlying cause of cancer. Mitochondrial damage comes first. 

If true – and I think it is – the metabolic theory of cancer is the most important breakthrough in cancer research in decades.  

Meanwhile, enter Dr Ko, who has found a game-changing way to exploit this discovery. 

Trojan horse sneaks inside cancer cells 

When she joined Dr Pedersen, Dr. Ko threw herself into this research. Dr. Pedersen has a reputation as a workaholic, not taking a day off work in 22 years, but Dr. Ko surpassed his efforts, putting in 18 hour days and even sleeping in the lab. 

Fortunately, her dedication paid off. 

Because cancer cells produce a great deal of lactic acid, they need a way of expelling it, otherwise the cells would die of toxicity. To do this they create a lot of transporters to carry the acid, and pores to form an escape route for it. 

Dr. Ko wondered whether this difference between a normal cell and a cancer cell could be exploited. 

When working for her doctorate she studied 3-BP. The molecule mimics the chemical structure of lactic acid except that it’s very reactive. 

Her idea was that the cancer cell would mistake 3-BP for lactic acid. This would allow the substance to sneak into the cancer cell through the same pores that allow lactic acid to escape. It would act like a Trojan horse, creating havoc inside the mitochondria, shutting down both forms of energy production. 

Breathtaking, unbelievable results 

Initial laboratory testing of the molecule on human liver and breast cancer cell lines was compared with other chemotherapy agents such as cisplatin. The results were astonishing. 3-BP was far more powerful. The results were so surprising she found them hard to believe, so she repeated the test a hundred times. The results were the same. 

Testing on cancer cells cultured in a petri dish is one thing, the next big test would be in an animal model. 

Human liver cancer cells were seeded into 19 rats until the cancers grew 2-3 cm. These advanced cancers were then treated with 3-BP. 14 animals were used as controls and treated with saline. After 6 or 7 days all controls had to be euthanized. 

But in every 3-BP-treated animal the cancers were eradicated without toxicity within four weeks. Seven months later all remained alive, well and cancer free. 

This research was published in 2004. 

Subsequent research by the Johns Hopkins team and other labs has shown that 3-BP inhibits an enzyme called hexokinase II which promotes the use of glucose for cellular energy. This enzyme also helps to immortalize cancer cells. 

3-BP has demonstrated the following attributes: 

• It is specific to cancer with little effect on normal cells 
• It starts depleting energy reserves within minutes 
• It doesn’t merely damage cancer cells, it kills them outright. Cancer cell membranes rupture and explode in rapid time 
• After completing its mission, 3-BP destroys itself. It doesn’t remain on the loose to create any potential risks 
• It exhibits little or no toxicity 

Why are we waiting? 

Dr. Pomper wasn’t the only one inspired by the animal study. Dr. David Hockenbery of the Fred Hutchinson Cancer Research Center in Seattle said the results were “quite dramatic and quite impressive.” 

And yet, twelve years on, there have been no human trials. 

Why? 

The fact that 3-BP is a very cheap, common chemical that can’t be patented is certainly part of the explanation. The cost to patients from using 3-BP is estimated at 70 cents per day. 

Another reason is that a falling out took place between Dr. Ko and her employers, resulting in her dismissal and a long lawsuit. Although clinical trials have been held up, Dr. Ko is optimistic these will take place soon. We can only hope her optimism is justified. 

Better than any anti-cancer drug 

There have been anecdotal reports of remarkable cures in a small number of people, but the following case report is the only example published in a medical journal. 

Just 16 years old, Yvar had the fibrolamellar carcinoma form of liver cancer. There is no known treatment other than transplantation, but he did not fulfill the requirements. 

He was treated with the ‘gold standard’ liver drug sorafenib but benefits were short-lived. 

Treatment with 3-BP began in February, 2009. Yvar’s very poor appetite was quickly reversed. Enlarged spleen was drastically reduced. Indications of tumor death were evident. Regeneration of liver tissue was observed. By the summer he started to regain his physical strength. 

Unfortunately, in spite of regeneration of liver cells, liver functions were overloaded and couldn’t cope with the rapid destruction of tumor cells. The liver couldn’t detoxify dead cancer cell debris fast enough. Yvar died two years after first diagnosis, although he lived much longer than expected, and with an improved quality of life. 

The authors of the study noted that “the rate of tumor necrosis [death] due to 3-BP treatment seems to exceed all known cytostatic [anti-cancer] drugs.” 

Late-stage lung cancer cured with combination therapy 

In September 2014, doctors at the Cancer Treatment Institute of Columbia reported on a 66-year-old man with stage IV small cell lung cancer. The usual treatments had failed and his prognosis was poor. 

He was treated with 3-BP and the antibacterial and anti-cancer stem cell agent salinomycin. Four weeks later, chest CT scans revealed the total disappearance of the disease. 

Dr. Jason Williams, a member of the study team, said, “These two drugs are exceptional on their own, but it’s their combination that’s proving to be instrumental. Salinomycin and 3-BP work together to disable the cancer cell’s energy production and reduce the proportion of cancer stem cells. 

“Our initial work with human subjects has been more successful than we could have imagined.” 

Treatment with 3-BP is available 

3-BP is not approved by the FDA, and Dr. Ko does not recommend treatment from a ‘non-certified’ facility. To us old hands in alternative cancer treatment, this is no cause for alarm. 

Use of 3-BP in human patients is limited. While it should work on all tumors that exhibit the Warburg Effect (these will light up on PET scans), much is yet to be determined regarding dosage, timing and combination with other drugs or treatments. 

The concept has not been tested, but in theory 3-BP should work better with a ketogenic diet that greatly limits carbohydrates – a dietary strategy for starving cancer cells that can only metabolize carbohydrates. 

There are many unanswered questions, but nevertheless some German clinics offer this treatment. It is also available at the Dayspring Cancer Clinic in Scottsdale, Arizona, and at Cancer Immunotherapy Centers in Toronto, Canada. SOURCE: Cancer Defeated – August 10, 2016 

References: 

http://www.ncbi.nlm.nih.gov/pubmed/15465013

http://www.ncbi.nlm.nih.gov/pubmed/22382780

http://media.wix.com/ugd/dd6ff6_d688f4da03584a6abeae3b4fabacbbab.pdf

http://www.ncbi.nlm.nih.gov/pubmed/22328020

http://www.prnewswire.com/news-releases/cancer-treatment-institute-of-colombia-demonstrates-unprecedented-results-using-unique-cancer-drug-combination-of-3-bromopyruvate-and-salinomycin-for-treatment-of-multiple-types-of-cancer-277467361.html

Researchers measure the impact on cancer stem cell metabolism of 3 natural substances, 3 experimental pharmaceuticals and 1 clinical drug. 

Vitamin C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists in Salford, UK. 

The research, published in Oncotarget, is the first evidence that Vitamin C (ascorbic acid) can be used to target and kill cancer stem cells (CSCs), the cells responsible for fuelling fatal tumours. 

Dr Michael P. Lisanti, Professor of Translational Medicine at the University of Salford, said: “We have been looking at how to target cancer stem cells with a range of natural substances including silibinin (milk thistle) and CAPE, a honey-bee derivative, but by far the most exciting are the results with Vitamin C. 

“Vitamin C is cheap, natural, non-toxic and readily available so to have it as a potential weapon in the fight against cancer would be a significant step.” 

Cancer stem-like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth). 

The Salford team set out to assess the bioenergetics of cancer stem cells — the processes which allow the cells to live and thrive — with a view to disrupting their metabolism. 

Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drug stiripentol, 3 natural products — caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid — and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG. 

While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with Vitamin C, outperforming 2-DG by tenfold in terms of potency. 

Vitamin C has previously been shown to be effective as a non-toxic anti-cancer agent in studies by Nobel Prize winner Linus Pauling and was recently shown to reduce mortality by 25% on breast cancer patients in Japan. However, its effects on CSC activity have not been previously evaluated and in this context, it behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the “powerhouse” of the cell. 

Dr. Gloria Bonuccelli, lead author and another member of the Salford team added: “This is further evidence that Vitamin C and other non-toxic compounds may have a role to play in the fight against cancer. 

“Our results indicate it is a promising agent for clinical trials, and a as an add-on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis.” SOURCE: Science Daily – University of Salford – March 7, 2017 

Journal Reference: 

1. Gloria Bonuccelli, Ernestina Marianna De Francesco, Rianne de Boer, Herbert B. Tanowitz, Michael P. Lisanti. NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness”. Oncotarget, 2015; DOI: 10.18632/oncotarget.15400

Laetrile is the commercial name for a modified form of amygdalin, which is also known as bitter almonds. 

Chinese doctors allegedly used this substance, which is highly concentrated in the pits of apricots and other fruits, some 3,500 years ago for the treatment of tumors. Dioscorides of Anazarbos, 2000 years ago, was perhaps the first to document it. It was usually administered in the form of bitter almonds.  

Modern laetrile is usually derived from apricot kernels where it comprises about 2-3% of the kernel, a relatively large amount. It’s also found in the kernels of other fruits, such as plums, cherries, peaches, nectarines, and apples. All fruit seeds have a healthy form of organic cyanide in them, from apple seed to apricot seed, although laetrile treatments have been alleged to cause cyanide poisoning.  

The fruit kernels or seeds generally have other nutrients as well — some protein, unsaturated fatty acids, and various minerals. Although often called B17, laetrile is not found with other B vitamins in yeasts. Many plants do contain some laetrile, with the sprouting seeds, especially mung bean sprouts, containing the highest amount.  

The diet of primitive man and most fruit-eating animals was very rich in nitrilosides. They regularly ate the seeds (and kernels) of all fruits, since these seeds are rich in protein, polyunsaturated fats, and other nutrients. Seeds also contain as much as 2% or more nitriloside. When civilized humans eat less than the whole fruit — for example, by discarding the seed or kernel — they experience a specific and total deficiency not only in oils and proteins but also in minerals and such vitamins as B17 (nitriloside) because it is found only in the seed, not in the flesh of the fruit.  

Several other foods are naturally rich in nitriloside, including lima beans, succotash containing nitriloside-rich chick peas, plum jam, elderberry wine, bean sprouts, millet sprouts, sorghum molasses, wild berries, raspberries, macadamia nuts, and nitriloside-rich bamboo sprouts.  

Nitriloside was “rediscovered” in 1920 by a California physician, Ernest Krebs while experimenting with flavorings for bootleg whisky. His son, Dr. Ernest Krebs, Jr., purified it and coined the name ‘laetrile’ in 1952. Krebs’s studies showed that when a human or animal system ingests sufficient amounts of laetrile (or in its natural form, hydrocyanic acid), this substance becomes selectively toxic to cancer cells.  

In the early seventies, Dr. Harold Manner of the Biology Department at Loyola University, Chicago, conducted a study on a strain of mice using a combination of enzymes, Vitamin A, and laetrile. He reported in his book, Death of Cancer:  

“After 6-8 days, an ulceration appeared at the tumor site. Within the ulceration was a pus-like fluid. An examination of this fluid revealed dead malignant cells. The tumor gradually underwent complete regression in 75 of the experimental animals. This represented 89.3% of the total group.” (quoted in Moss, 1982).  

Laetrile needs to be taken with vitamin A and enzymes to be most effective.  

Pure laetrile has been illegal in the U.S. for decades and was pulled from the shelves in Britain.  

Challengers claim it is potentially toxic and leads to cyanide poisoning. As late as the end of the 1970s, between 50,000 and 100,000 cancer patients were ingesting close to 1 million grams per month. Only between two and three deaths were reported from accidental overdose. Considering these statistics, laetrile does not seem as toxic or dangerous as opponents make it out to be.  

Laetrile has been described as a parcel that contains poisons that are only released once the parcel is unwrapped. It has an effect on cancer cells because those cells secrete the enzyme beta-glucosidase that releases the cyanide, which then poisons the cancer cells. In contrast, normal cells have the enzyme rhodanase which effectively renders the cyanide molecule inactive. In the absence of cancer cells, the toxic cyanide is not released.  

Laetrile/amygdalin is not digested in the stomach by hydrochloric acid. Instead, it passes into the small intestine where it is acted on by enzymes that split it into various compounds, which are then absorbed.  

Laetrile can be separated by appropriate enzymes, in the presence of water, into glucose, benzaldehyde, and hydrocyanic acid. The last two substances are each, individually, a poison, but together they work synergistically and become more powerful when combined than when used separately.  

In the treatment of cancer, laetrile is used to reduce tumor size and further spread of the disease, as well as to alleviate the sometimes severe pain of the cancer condition.  

Laetrile does not make tumors grow smaller, so the question of tumor regression is sometimes brought up as evidence that laetrile is ineffective. Laetrilists argue that tumor size is not a good indicator of anticancer activity because a tumor does not just consist of malignant cells. Tumors also contain normal cells.  

When chemotherapy is used, all cells are attacked so it’s not unusual to see short-term tumor regression (because both malignant and normal cells are killed). Unfortunately, the long-term result of such treatment is for the tumor to become more aggressive due to the chance of increasing the ratio of malignant cells. In the case of laetrile, however, normal cells are not affected and so tumors do not decrease in size. Instead, they become benign.  

According to pathologist Gerald Dermer, “There is a marked discrepancy between ostensible tumor response and actual patient survival. In only about 32% of the clinical trials that reported significant tumor responses to new drugs was survival also prolonged.” In other words, tumor “response” or shrinkage may be largely irrelevant to controlling cancer, and the charge that laetrile doesn’t shrink tumors may be likewise irrelevant.  

Nearly all laetrile supporters advocate a diet of raw vegetables in conjunction with the therapy, partly because such a diet contains a large amount of dietary laetrile. Indeed, one of the things that makes the laetrile controversy so bizarre is that laetrile is a very common component of food.  

Between 1,200 and 2,500 plants contain laetrile. This includes most cereals and fruits and many vegetables. A diet that contains high quantities of the following will also be high in laetrile: chickpeas, bean sprouts, nuts, mung beans, blackberries, raspberries, and the seeds of apples, apricots, cherries, plums, and pears.  

Laetrile’s safety was demonstrated in an experiment with mice undertaken at a leading US cancer research institution (Memorial Sloan-Kettering Cancer Center). For thirty months, mice were injected daily with laetrile at a rate of 2 grams per kilogram of body weight (equivalent to giving a human a quarter of a pound a day). At the end of the period, the mice were healthier and exhibited greater wellbeing than the control group that did not get any laetrile.  

Refer to The Cancer Syndrome by Ralph Moss for more details.  

In addition, it should be noted that some young plants develop their own naturally occurring pesticides to provide some protection against insects and rodents. These pesticides are rich in nitrilosides, which are similar in chemical structure to laetrile. This presents the question that a diet high in young fresh plants such as alfalfa sprouts is like undergoing continuous non-toxic chemotherapy that kills pockets of cancer cells before they divide and grow.  

Laetrile authority Elson M. Haas M.D. says, “When used, laetrile is administered at 250-1,000 mg. (a gram is a thousand milligrams) daily. Higher amounts, up to 3 grams per day, have been used, but divided into several smaller dosages, each usually limited to 1 gram. If the source is whole apricot kernels, the quantity is usually about 10-20 kernels per day; 1-2 cups of fresh mung bean sprouts may provide an equivalent amount. If apricot kernels are blended or pulverized, it is suggested that they be consumed immediately.” SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

• The cancer syndrome: With an afterword to the 1982 edition by Ralph W. Moss (1982)  
• World Without Cancer: The Story of Vitamin B17 by G. Edward Griffin (2010)  
• Death of Cancer by Harold Manner (1979)  

• Alive and Well: One Doctors Experience With Nutrition in the Treatment of Cancer Patients by Philip E. Binzel Jr. (1994)  
• Laetrile Control for Cancer by Glenn D. Kittler (1963)  
• Politics, Science and Cancer: The Laetrile Phenomenon by Gerald Markle (1980)  
• The Little Cyanide Cookbook; Delicious Recipes Rich in Vitamin B17 by June De Spain (2000)  
• Vitamin B-17- Forbidden Weapon Against Cancer: The Fight For Laetrile by Michael L Culbert (1974)  

• Laetrile Control for Cancer by H. Knaus (1963)  
• Too Young to Die: Dramatic Use of Laetrile to Conquer Terminal Cancer by Rick Hill (1979)  
• An Alternative Medicine Definitive Guide To Cancer by W. John Diamond and W. Lee Cowden, (1997)  
• Vitamin B17—Laetrile, http://www.healthy.net/scr/article.aspx?Id=1926  
• “Amygdalin,” Memorial Sloan-Kettering Cancer Center, http://www.mskcc.org/mskcc/html/11790.cfm?Disclaimer_Redirect=%2Fmskcc%2Fhtml%2F69118.cfm  

Artemisinin, which is originally from Chinese folk medicine, is a type of chemical compound that comes from the common garden plant artemesia, or wormwood. It has been shown in studies to induce apoptosis (natural cell death) in human cancer cells. During an in vitro study, it successfully killed select cancer cells and slowed the growth of tumors in rats.  

In fact, Seattle scientists have shown that a compound extracted from the wormwood plant actually seeks out and destroys invaders such as breast cancer cells while leaving healthy cells unscathed. The substance is used extensively in European alternative cancer clinics.  

Artemisinin is considered a safe, non-toxic, and inexpensive alternative for cancer patients. Chinese researchers said the key to its effect was a peroxide linkage (two oxygen atoms hooked together) within the herb’s active molecule, which makes this treatment very similar to oxygen therapy. Cancer cells thrive in an oxygen-free (anaerobic) environment and high levels of oxygen are therefore fatal to them.  

In laboratory experiments, the compound killed virtually all human breast cancer cells that had been exposed to the compound over a span of 16 hours. These studies were conducted by Dr. Henry Lai and his bioengineering research team at the University of Washington. Dr. Lai also stated that nearly all of the normal cells exposed to the compound remained alive.  

In a separate experiment, a dog with severe bone cancer known as osteosarcoma couldn’t walk across the room. The animal made a complete recovery within five days of receiving the treatment. X-rays showed the animal’s tumor “had basically disappeared,” says Lai. He added that the dog survived for at least two more years.  

Artemisinin reemerged as a therapy for malaria, for which it was once common, after a “secret recipe” for the treatment was discovered on a stone tablet in the tomb of a prince of the Han Dynasty during an archaeological dig in the 1970s. In fact, a purified form of the plant compound is now the drug of choice for treating malaria.  

Experiments into why artemisinin works as an anti-malaria agent led to its being tested as an anticancer drug. The key turned out to be a shared characteristic of the malaria parasite and dividing cancer cells: high iron concentrations.  

When artemisinin, or any of its derivatives, meets iron, a chemical reaction ensues. This prompts the creation of free radicals. In malaria, the free radicals attack and bind with cell membranes, breaking them apart and killing the single-cell parasite.  

Lai points out that cells need iron to replicate DNA when they divide. Because cancer is characterized by out-of-control cell division, cancer cells have much higher iron concentrations than do normal cells.  

“Not only does [the drug] appear to be effective, but it’s very selective,” Lai says. “It’s highly toxic to the cancer cells, but has a marginal impact on normal cells.”  

On the surface, cancer cells have more so-called transferrin receptors than healthy cells have.  

Transferrin receptors are cellular pathways that allow iron to enter. In the case of breast cancer, the cells have five to 15 times more transferrin receptors on their surface than normal breast cells, Lai says.  

The main strategy, according to Lai, is to pump up cancer cells with even more iron and then introduce artemisinin to kill them selectively. In his experiments, Lai subjected sets of both breast cancer cells and normal breast cells to two substances. The first was a compound known as holotransferrin, which binds with transferrin receptors to transport iron into cells and thus further increases the cells’ iron concentrations.  

The second was a water-soluble form of artemisinin. He also studied a combination of both compounds.  

Cells exposed to just one of the compounds showed no noticeable effect, Lai reported. But the response by cancer cells when hit with first holotransferrin and then artemisinin was dramatic, he says.  

After eight hours, three-fourths of the cancer cells were obliterated. After16 hours, nearly all the cancer cells were dead. Just as importantly, he says, the vast majority of normal breast cells did not die, showing the safety of the treatment.  

The normal breast cancer cells were also resistant to radiation utilized in the experiment, Lai adds. “So that means this approach might work for cancer resistant to conventional therapy.” One might expect even more aggressive cancers such as pancreatic and acute leukemia, known for rapid cell division and so much higher iron concentrations, to respond even better.  

Further animal testing followed by human trials is expected. In human trials, patients would likely be given iron supplements to raise the iron concentrations in their cancer cells.  

Even though human tests are years away, the treatment could revolutionize the way cancer, especially the aggressive, fast-growing kind, is approached.  

One study found elevated iron storage in 88% of breast cancer patients, so the application is logical. There’s also a wealth of research linking iron and cancer.  

Artemisinin is best taken on an empty stomach with some natural fat to enhance absorption. If iron is present from residual food, it may neutralize the peroxides. Milk has a minimal amount of iron, as do cottage cheese and yogurt—and all three have enough fat to enhance absorption. Artemisinin is also administered intravenously in some clinics. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

• Chinese remedy ‘may fight cancer,’ http://news.bbc.co.uk/1/hi/health/1678469.stm  
• “Artemisinin induces apoptosis in human cancer cells.” http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15330172  

• Cancer Therapies Page: Artemisia or Sweet Wormword Anti-Cancer Herbs, http://www.huldaclarkzappers.com/php2/sweetwormwoodtherapy.php  

Carnivora® was discovered and developed by Helmut G. Keller, MD, oncological investigator at Klinik Winnerhof in Bad Wiessee, Germany. It enhances the immune system response. Carnivora® is comprised of the pressed juices of Dionaea Muscipula, a concentrated extract of the Venusflytrap plant. It is supplied as drops for oral ingestion and inhalation, and as Carnivorain injections for intravenous and subcutaneous administration.  

Carnivora® capsules are now available in the U.S. as a food supplement. Carnivora externally applied has helped with skin cancers and when taken in capsules. It may stop or reduce tumor growth. The active component of carnivora is plumbagin, a powerful immunological booster.  

Dr. Helmut Keller stated: “Carnivora®, a patented phytonutrient and extract of the Venus flytrap plant, Dionaea muscipula, has been used clinically for over 25 years.”  

Biologically active compounds in the extract are essential to healthy immune systems and to support healthy cardiovascular functions in the body. At higher doses, the extract has been shown to have immodulatory, tumoricidal, antimicrobial, antiviral, antiparasitic and antibiotic properties.  

The pharmacology of Venus flytrap extract has been extensively studied and evaluated in both animal and human studies.  

Professor D.K. Todorov, MD, PhD, DSc, and Chief of Oncopharmacology at the National Oncological Center of Bulgaria performed clinical studies on Carnivora for over two decades. He has conducted cancer research at Heidelberg University in Heidelberg, Germany. His findings involving various cell lines show that cancer cells were destroyed within a matter of hours when exposed to Carnivora.  

Dr. Todorov’s initial studies of sarcoma show the dramatic reduction of human sarcoma cells from 2500 to 880 over a 72-hour period. Additionally, Todorov found that 400 nanograms per milliliter (ng/ml) of Carnivora® had caused a diminution of 2200 multidrug resistant sarcoma cells to 1130 cells in just 72 hours.  

As a result of these in vitro findings, some doctors began to employ the protocol in vivo, treating patients with sarcoma tumors. Despite previous treatment with toxic therapies, some patients achieved remission.  

Professor Todorov performed a study on brain cancer by administering 200 ng/ml of Carnivora to human glioblastoma cells and achieved the destruction of 50% of these cells during a seven-day period.  

To study the effects of Carnivora against leukemia, Todorov used 200 ng/ml of Carnivora® to destroy human T-lymphoblastic leukemia cells. Thirty-one hundred of these cells were reduced to 1820 in 72 hours. He then took multi-drug resistant human leukemia cells and exposed them to 200 ng/ml of Carnivora to achieve remarkable results; within 72 hours, 2250 leukemic white blood cells were demolished to just 570 cells.  

Doctors have treated patients who suffer from chronic myeloid leukemia, as well as chronic lymphocytic leukemia with long-term Carnivora® therapy with great success. The key in this instance seems to be prolonged treatment. A majority of CML and CLL patients reported positive findings.  

And in the case of ovarian cancer, studies showed fifteen hundred ovarian cancer cells were dramatically reduced to 435 cells in a rat model in vivo when treated with 200 ng/ml of Carnivora® within forty-eight hours. Seventeen hundred eleven cells of human ovarian cancer were again dramatically reduced to a mere 359 cells upon exposure to 200 ng/ml of Carnivora® in just 48 hours. It was shown that despite this cancer’s chemotherapeutic resistance, Carnivora® had nearly destroyed this entire cell line. Carnivora® should not be used in conjunction with chemotherapy. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

• German Cancer Therapies: Natural and Conventional Medicines That Offer Hope and Healing by Morton Walker (2003)  

• http://www.carnivora.com/  
• Townsend Letter for Doctors and Patients, Nov, 2001 “Carnivora: Pharmacology and Clinical Efficacy of a Most Diverse Natural Plant Extract” http://the-medical-dictionary.com/chenodeoxycholic_acid_article_4.htm  
• “Carnivora fights Lyme,” http://www.mail-archive.com/silver-list@eskimo.com/msg25524.html  

Angelo P. John, a cancer theorist for more than 40 years, developed an extremely interesting and promising nutritional approach to help cancer patients. CAAT – Controlled Amino Acid Treatment — is a novel approach to cancer treatment. The treatment has been used since 1994 in very advanced-cancer patients combined with or without conventional treatment of radiation and/or chemotherapy. Angelo John develops these nutritional programs for cancer patients with the cooperation of the patient’s oncologist or with nutritionally oriented complementary and alternative physicians who work with cancer patients.  

CAAT is an amino acid and carbohydrate deprivation protocol that uses scientifically formulated amino acids. Based on the fact that the needs of normal cells and cancer cells are quite different, the diet of the cancer patient is manipulated to include a blend of amino acids (protein building blocks in the body). Cancer cells are literally starved to death.  

The program consists of:  

• A strict diet  

• A special amino acid blend—the exact blend depends to some extent on the type of cancer being treated  
• Certain nutritional supplements, and the avoidance of others  

The treatment attacks cancer cells in four ways:  

• Helps to prevent new blood vessel formation (angiogenesis), which is necessary for the growth of solid cancers.  
• Interferes with the cancer cell’s ability to produce energy by blocking a process called glycolysis in cancer cells.  

• Reduces the ability of the body to produce factors that stimulate growth of cancers.  
• Interferes with the production of specific amino acids that are necessary for DNA replication in cancer cells.  

The diet is quite strict and is low in both carbohydrates and protein. Fat intake is moderate and involves specific fats. The amino acid blend reduces certain amino acids (such as glycine, valine, leucine, and isoleucine) and increases others, resulting in reduced production of the protein elastin, which is necessary for angiogenesis.  

In contrast to normal cells, which produce energy primarily through the use of oxygen, cancer cells produce energy by a process known as glycolysis because their mitochondria (energy producing structures in cells that utilize oxygen) are damaged and not capable of utilizing oxygen the way normal cells do. The theory is that the strict diet and the blend of amino acids attack the glycolysis process in cancer cells, thus helping to prevent the production of energy in cancer cells.  

Certain growth factors produced in the body, such as human growth hormone and insulin growth factor 1 (IGF1) tend to stimulate cancer growth. This program with its reduced calorie and protein diet tends to reduce the production of these growth factors. The growth of cancer cells requires certain amino acids (like glycine) and nutrients (like vitamin B6) for replication of the cancer cells’ DNA. The reduction of these nutrients in this CAAT protocol helps to inhibit DNA replication in cancer cells.  

A number of nutritional supplements are part of the program. These may include, but are not limited to:  

• Vitamins A, C and D  
• D-Limonene  
• N-Acetylcysteine (NAC)  
• Grape Seed Extract  

• Lycopene and others  

On the other hand, most of the B vitamins, especially vitamin B6, are avoided because they enhance the glycolysis process or DNA replication.  

Regardless of the cancer type, all cancer cells survive through the same biochemical processes. CAAT interferes with these processes and causes the cancer cells to die, significantly increasing the patients’ chance of recovery. However, because each patient is unique, CAAT is designed for one’s specific needs, taking into account the patient profile and medical history. A personalized amino acid deprivation formula and food plan is designed for each patient’s individual requirements. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

• Controlled Amino Acid Treatment (CAAT)-A Novel Nutritional Approach to Cancer Treatment by Michael B. Schachter, MD, CNS, FACAM  

• A.P. John Institute for Cancer Research http://www.apjohncancerinstitute.org/  

An Italian doctor, Dr. Tullio Simoncini, was a trained surgeon, oncologist, endocrinologist, and diabetologist, with a University degree in philosophy. He became disturbed by what he viewed as the medical community’s blanket acceptance that cancer is ‘incurable’. He noted that the ‘genetics’ paradigm was 80 years old, and had never been proven—and the billions of dollars spent on chemotherapy and irradiation were doing nothing to improve survival rates.  

Dr. Simoncini contended that psoriasis, an incurable disease, is caused by a fungus, and this inspired him to think that perhaps cancer, another incurable disease, could also be caused by a fungus. There’s some evidence for his belief. Many works now document the presence of fungi in cancer patients’ tissues, especially in terminal patients.  

Of all the fungi that cause diseases in humans, proponents of this theory say that Candida is the sole agent responsible for tumors as well as other serious illnesses, such as septicemia. Candida is always present in the tissue of cancer patients. Fungi also cause tumors in the plant and insect kingdoms.  

Simoncini says most people, including doctors, underestimate the damage that opportunistic fungi can—and will—inflict.  

Fungi establish permanent, parasitic colonies. These colonies spread widely all through the body. They’re able to communicate with one another and to dominate host organisms.  

In most cases, neither patients nor doctors recognize the symptoms of fungal overgrowth. Most doctors will tell a patient the problem is local (for instance, bad digestion or a skin rash), rather than systemic (i.e. affecting the whole body).  

The immune system—when it detects a fungal enemy—tries to eradicate it before it can establish high-growth colonies. Unfortunately, a compromised immune system may be unable to do that. Fungi can bypass the epithelia and immune system and penetrate deeply into connective tissue, causing a biological reaction that tries to encapsulate the fungus—to form a container around it—the familiar bulbous tumor. However, the fungus colony not only expands aggressively in the original location, but pursues new habitats (metastasis).  

Fungi mutate into different shapes throughout their life cycle—shedding their cell wall to become nearly invisible under a microscope. This is one reason fungal infections can’t be detected in blood culture until the patient is nearly dead.  

At first, a patient is able to send mature cells to contain the fungi, now a differentiated tumor. But when fungus colonies become more powerful and the tissues become exhausted, they revert to ‘simpler’ forms that don’t require the higher-level functions of healthy differentiated cells such as lung cells or prostate cells.  

Advocates of this cancer theory say it’s always the same highly-adaptive Candida attacking different tissues—each time mutating and adapting itself to its new environment. Scientists think Aspergillus is a variation of Candida.  

The preferred treatment is to oxygenate the body, because cancer cells thrive in a low- or no-oxygen environment. A number of different cancer protocols attempt to oxygenate the body in different ways.  

Cancer cell growth is initiated by fermentation, triggered by the absence of oxygen at the cellular level.  

The body of cancer patients is characterized by an unhealthy acidity. In contrast, a healthy body is slightly alkaline. A high level of acidity prevents oxygen from accessing the tissues in need of it. Acidity also promotes a build-up of carbon dioxide in the tissues, leading to cell death. Many cancer experts besides Simoncini share the belief that a successful treatment plan should render the patient’s body more alkaline. But relatively few follow Dr. Simoncini’s method for doing so.  

Dr. Simoncini’s approach is to alkalinize the body with a solution of sodium bicarbonate — simple baking soda. The Simoncini protocol has earned a devoted following among people who advocate self-treatment, although it’s also used by some respected cancer doctors. There are countless testimonials to Dr. Simoncini’s protocol available online.  

According to the protocol’s advocates, sodium bicarbonate shocks cancer cells with massive amounts of oxygen which kills them like a poison, while leaving normal cells unharmed.  

It’s reported that sodium bicarbonate shrinks a two to four centimeter mass of cancer cells in only 4 to 5 days. Some patients are said to experience complete remission within 5 days.  

Sodium bicarbonate can be administered three ways: by mouth, with an aerosol, or intravenously.  

The more hard-to-reach cancers are treated by positioning catheters directly into the artery that nourishes the tumor, allowing high doses of sodium bicarbonate to enter the deepest recesses of the cancer mass. Today it’s even possible to reach cerebral masses without surgical intervention, in a completely painless way.  

Advocates say most tumors can be treated effectively with baking soda therapy—except for bone cancer, due to the lack of blood flow to the bones.  

A 2009 study showed sodium bicarbonate increases the pH of tumors, and reduce metastases and lymph node involvement (in breast cancer).  

The therapy is said to be extremely effective, painless, free of side effects, and very low risk. With catheterization, there’s a small risk of infection.  

It’s also inexpensive, at least in terms of the equipment and materials required. Catheters cost a bit more, but taking bicarbonate by mouth costs only pennies per day.  

Application via catheter, applied directly to the tumor, can be provided only by a mainstream doctor. Most won’t be willing to provide such a treatment. Also, full dosages cannot be administered to those with severe heart, kidney, and liver problems.  

Based on Simoncini’s theory it might seem logical that antifungal drugs would be effective anti-cancer drugs. Advocates say this is not the case. None of the antifungal drugs on the market share the effectiveness of sodium bicarbonate because they cannot penetrate tumor masses. In addition, fungi resist these drugs by quickly mutating into a different form. Finally, it’s alleged that the drugs weaken the immune system.  

Sodium bicarbonate, on the other hand, reportedly spreads in all directions and fungi cannot easily resist it—largely because it works so fast to disintegrate them that they can’t adapt to defend themselves.  

Therefore, advocates of this protocol recommend that a strong dosage should be used continuously, without interruption, for at least 7-8 days for the first treatment cycle.  

Advocates of this approach advise patients to add 1-2 teaspoons of aluminum-FREE baking soda and 1 teaspoon of pure maple syrup to 1 cup of water, and drink. Some sources say to heat it first. The ‘sugar’ acts as a delivery mechanism to hard-to-reach Candida cells. Mark Sircus, Ac OMD suggests doing this every 2 hours for no more than 2 weeks.  

This protocol is not recommended if the body is already alkaline. However, most cancer patients are acidic.  

Simoncini’s theory that fungus is the main cause of cancer is highly controversial, although many support the acid-alkaline theory of cancer causation and treatment. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

• The Germ that Causes Cancer, by Doug A. Kaufmann  
• Sodium Bicarbonate: Rich Man’s Poor Man’s Cancer Treatment, by Dr. Mark Sircus, Ac., O.M.D.  
• Dr. Simoncini Web site: http://www.curenaturalicancro.com  
• Robey IF, Baggett BK, Kirkpatrick ND, et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res. 2009;69:2260-2268  

Graviola, which is the common name for Annona reticulata, is a fruit also known as soursop, guanabana, and custard apple. It comes from a tree common to South America and the Caribbean region. The leaves of the tree are commonly used in traditional medicine treatments to treat diarrhea and eliminate worms.  

Proponents claim it is more effective at killing colon cancer cells than common chemotherapeutic drugs because it seeks out and destroys prostate, lung, breast, colon, and pancreatic cancers while leaving healthy cells unharmed. It is also said to provide an immune system boost.  

The National Cancer Institute included graviola in a plant-screening program that showed its leaves and stems were effective in attacking and destroying malignant cells. Strangely, the results were never released to the public and remained part of an internal NCI report.  

There have been several promising cancer studies on graviola since 1976, when it was first introduced, but the tree’s extracts have yet to be tested on cancer patients. No double-blind clinical trials exist.  

Regardless, graviola has been shown to kill cancer cells in vitro (i.e., in laboratory cell cultures) in as many as 20 laboratory tests. A study conducted at Catholic University of South Korea demonstrated two chemicals extracted from graviola seeds were selective in cytotoxicity and comparable with Adriamycin (a common chemotherapy drug) for targeting and killing malignant breast and colon cancer cells.  

Perhaps the most significant result of this study and others is that Graviola was shown to selectively target only cancer cells, leaving normal, healthy cells untouched.  

By comparison, chemotherapy indiscriminately seeks and destroys all actively reproducing cells, including normal hair and stomach cells, which leads to the devastating side effects of hair-loss and severe nausea.  

Another study, published in the Journal of Natural Products, showed that graviola also outperforms Adriamycin in laboratory tests. One chemical found in graviola selectively killed colon cancer cells at 10,000 times the potency of Adriamycin.  

Research from Purdue University detailed the active components of the tree, which may be potent in inhibiting the growth of cancer cells. The Purdue studies found the active components to be effective against multi-drug-resistant (MDR) cancer cells, those cells that survive chemotherapy and cause cancer to return.  

Purdue researchers also found that leaves from the graviola tree killed cancer cells “among six human-cell lines” and were especially effective against prostate and pancreatic cancer cells.  

In a separate study, Purdue researchers showed that extracts from the graviola leaves are extremely effective in isolating and killing lung cancer cells.  

Graviola looks to be a promising alternative or supplement to mainstream treatments. Graviola and N-Tense (an anti-cancer formula featuring graviola and seven other rainforest herbs) are completely natural substances. No side effects have been reported except for possible mild gastrointestinal upset at high dosages (in excess of 5 grams) if taken on an empty stomach. See N-Tense, a patented substance that contains 50% graviola. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

• Memorial Sloan-Kettering Cancer Center: Graviola, http://www.mskcc.org/mskcc/html/69245.cfm  

• Weil: Graviola: A Worthwhile Botanical Against Cancer? http://www.drweil.com/drw/u/QAA400299/graviola-a-worthwhile-botanical-against-cancer  
• The Healing Power of Rainforest Herbs: A Guide to Understanding and Using Herbal Medicinals by Leslie Taylor (2005)  
• Graviola Leaf For Cancer (Soursop), http://www.fasting.ws/juice-fasting/disease-treatments/graviola-leaf-for-cancer-soursop  
• Graviola Tree and Paw Paw Treatments, http://www.cancertutor.com/Cancer/Graviola.html  

Poly-MVA is a uniquely formulated nutritional supplement designed to provide energy for compromised body systems. It is helpful in increasing energy, reducing fatigue, and enhancing overall health and well-being, and can be particularly helpful in addressing those symptoms in people who are receiving chemotherapy or radiation treatments for cancer. Many people have found Poly-MVA to be helpful in improving quality of life while undergoing a difficult treatment regimen.  

The Poly-MVA name comes from the combined terms Poly meaning “many, much, more than one”; M indicating “minerals”; V signifying “vitamins”; and A symbolizing “amino acids.” Poly-MVA is a proprietary blend of palladium, alpha-lipoic acid, vitamins, B1, B2 and B12, the amino acids formyl-methionine and acetyl cystiene, and trace amounts of molybdenum, rhodium, and ruthenium.  

According to the inventor of Poly-MVA, Merrill Garnett, DDS, PhD, cancer results from the failure of cells to mature. This in turn is caused by a problem of energetics in the cell’s metabolic processes. He has developed a chemical compound, palladium lipoic acid, that mimics an energy pathway present in normal cells but missing in cancer cells, and necessary to normal growth and health. As a new principle in the nutritional healing of most cancer types, Poly-MVA assists in correcting malfunctioning nucleic acids in the deoxyribonucleic acid (DNA) of genes.  

Dr. Garnett emphasizes that he chose to bind palladium to alpha lipoic acid (ALA) because this amino acid is both water and fat-soluble and able to travel everywhere in the human body, even through the blood-brain barrier, taking the palladium molecule with it.  

Dr. Garnett, whose Garnett McKeen Laboratory is located in Islip, New York, has produced a self-published book, First Pulse: A Personal Journey in Cancer Research. In it, the author-scientist offers a philosophical, highly technical, but interesting and anecdote-filled discussion of how he came to create his invention.  

Dr. Garnett searched for singular substances capable of binding together the various ingredients which make up Poly-MVA. He found the therapeutic component in the platinum-derived palladium mineral, poisonous in the hands of an allopathic dentist, but life saving for someone suffering from cancer. Yet palladium would be poisonous to cancer patients too, if it were not bound tightly to alpha lipoic acid and “sequestered” in the molecule as cobalt is sequestered in vitamin B12. Thus, palladium forms an organic metallo-vitamin-lipoic acid complex that joins with cobalt, a part of the vitamin B12 (cyanocobalamin) complex.  

Dr. Garnett created Poly-MVA based on knowledge unknown before he discovered what he calls the Second Genetic Code, regarded by some as a scientific breakthrough. (See the Garnett book for details about the highly complicated Second Genetic Code discovery.)  

Dr. Garnett discovered that palladium acts as an excellent catalyst for combining oxygen and hydrogen; the metal absorbs over 900 times its volume of hydrogen. His formula adapts palladium for strengthening the actions of other molecules, too; e.g., iron holds together the active parts of hemoglobin, and its holding action is reinforced in the presence of palladium. Other amino acids besides alpha lipoic acid make up some part of the Garnett formulation.  

“Patients I’ve observed taking Poly-MVA have thrived. Numbers of them are following its protocol now. In my opinion Dr. Garnett and Dr. Sanchez are providing a really well thought out, safe treatment for all types of malignancies. They should be commended,” affirms Dr. Stanley R. Olsztyn.  

Poly-MVA is manufactured as a liquid mostly for oral ingestion, although some physicians administer it intravenously (see the procedure reported below by David C. Korn, MD(H), DO, DDS, of Apache Junction, Arizona):  

“Since PC Spes [a popular prostate cancer treatment] was removed from the market by the FDA almost two years ago, I have substituted the administration of both intravenous and oral Poly-MVA for prostate cancer patients and found it to act effectively. After receiving the new product IV for six or eight weekly injections and simultaneously taking the liquid in water, my male patients find their prostate specific antigen (PSA) markers come down. They go on to take the oral liquid Poly-MVA alone for approximately ten or twelve weeks more. This protocol affords great results. Recently two of my patients dropped down to a PSA of one from much higher markers.  

“I believe that saturating the blood with Poly-MVA insures the nutrient’s elevated dosage swiftly penetrates into the prostate area, the brain, and other organ sites. The patient with blood saturation of Poly-MVA goes through a physiologic range of reactions illustrated by an elevation of body temperature. I administer the treatment for lymphoma, brain cancer, breast cancer, prostate cancer, and more.  

“Insulin potentiation therapy works well in conjunction with Poly-MVA. But for elderly men with bone pain from prostate metastases who are frail, my preference is to administer the Garnett treatment alone. It acts just like a ‘smart bomb’ for pain relief, requiring four or five hours of the IV Poly-MVA. Based on an educated estimate of tolerated IV liquid, my staff and I gradually increase the dosage to 15 or 20 cc.  

I additionally include vitamin E, CoEnzyme Q10, lycopene, saw palmetto, and other prostate-specific nutrients.  

“My impression is that the Poly-MVA molecule actually behaves like a mild chemotherapeutic agent, but it is safe and not destructive. Moreover, the Lipoic Acid Palladium Complex is highly effective for increasing cancer remission rates,” confirms Dr. Korn.  

From the established therapeutic effects of its alpha lipoic acid/palladium complex, Poly-MVA provides at least 13 recognized anticancer benefits. The benefits are listed here from observations described by Dr. Merrill Garnett in a series of reports published on his animal studies conducted at the Garnett McKeen Laboratory. He has advised that the lipoic acid/palladium complex:  

• Causes an indefinite variety of immune system responses, but with specific manifestations as indicated in the twelve additional attributes listed below. 

• Seeks out and destroys cancer cells anywhere in the body by stealing their electromagnetic energy.  
• Invigorates normal cells and helps to repair any damage the invasive cancer may have left behind.  

• Reduces tumor size or causes the tumor to shrink.  
• Produces an idiosyncratic set of effects, which include a pattern of lag-arrest-slow death of cancer cells from an inhibition of their energy metabolism.  
• Prevents sterol biosynthesis, thereby preventing new cancer cell plasma membrane synthesis.  
• Shows a very large fraction of sensitive cancer cells as a morphological feature.  
• Promotes the growth of proliferating normal cells surrounding a core of central tumor necrosis consisting of dead cancer cells.  

• Stimulates the infiltration of leukocytes for the removal of cancer cell debris.  
• Has absolutely no toxic reaction and no adverse side effects.  
• Accomplishes its therapeutic benefits in both animals and humans.  
• Works against cancer of many types not only as an orally-administered liquid but also perhaps even more effectively as an intravenous injection.  
• Reduces the incidence of cachexia( (the “wasting away” characteristic of cancer patients) with a potential for increased body weight  

The late oncologist Dr. Rudy Falk’s original anticancer usage protocol strictly for cancer prevention consisted of only 1/2 teaspoonful a day of Poly-MVA. For therapy, a new and updated Poly-MVA protocol is now enthusiastically recommended by the Advanced Medicine and Research Center (AMARC) of Chula Vista, California. The protocol is presented in a publication written by Albert Sanchez, Sr., PhD, EdS, and made available by AMARC.  

From the http://www.polymvasurvivors.com website:  

“As noted in the letters below, oncologists & physicians are reporting the benefits of Poly MVA when used in conjunction with conventional cancer treatments or as part of other protocol therapies. These physicians are reporting complete remission of aggressive, stage IV cancers that have metastasized as well as continued positive responses in other patients with previously chemo-resistant cancers. Other noted benefits have been significantly improved quality of life and a substantial reduction in the number and severity of side effects from chemo and radiation therapies.”  

The Cancer Screening & Treatment Center of Nevada, for example, reported a 70% Positive Response Rate in Stage IV Cancer Patients At the same website, the Four Corners Approach is described that apparently has proved very effective for cancer survivors, including those who had been deemed late-stage: SOURCE: Alternative Cancer Research Institute 

• Destroy anaerobic (cancer) cells  

• Improve the immune system  
• Detoxify the body  
• Reverse acidosis (low body pH)  

Further Reading & References  

• Poly-MVA: Palladium Lipoic Complex, http://www.polymva.com/ (Note: For informational purposes only; not an endorsement)  

• http://www.polymvasurvivors.com/  
• Townsend Letter for Doctors and Patients, Feb-March, 2003: Cancer remission rates increase from use of the safe and effective lipoic acid palladium complex poly-MVA – Medical Journalist Report of Innovative Biologics.” http://www.findarticles.com/p/articles/mi_m0ISW/is_2003_Feb-March/ai_97994368  
• Diseases, 2nd Edition. (Springhouse, Pennsylvania: Springhouse Corporation, 1997), pp. 362-364.  
• Sanchez, A. What You Must Know to Overcome Cancer. (Chula Vista, California: ARMARC, 2001), pp. 51-54.  
• Garnett McKeen Laboratories: Nucleotide reductase. U.S. Patent No. 557,637 (October 31, 1995).  

• Diamond, W.J.; Cowden, W.L.; Goldberg, B. An Alternative Medicine Definitive Guide to Cancer. (Tiburon, California: Future Medicine Publishing, Inc., 1997).  
• Garnett, M. First Pulse: A Personal Journey in Cancer Research, Second Edition. (New York, New York: First Pulse Projects, Inc., 2001).  
• Poly-MVA Cancer Breakthrough: Palladium Lipoic Complex. (Chula Vista, California: AMARC, 2001), p. 4.  

Dr. Maud Tresillian Fere was a conventional medical doctor in all ways except for her view of cancer treatment. She strongly believed in the power of dietetic control combined with simple supplementary medication. In fact, using these methods was how she claimed to have healed her own cancer of the bowel.  

Dr. Tresillian Fere stresses the importance of understanding exactly what goes into the food and drink you consume on a daily basis. She shares vital information on water, sources of the best carbohydrates and proteins, and what she calls “cleansing foods,” which are raw vegetables and fruits. In addition, she held that excessive sodium, along with breaking the Laws of Good Health as she describes them, were the most common cause of cancer development.  

She also touts health habits such as getting plenty of fresh air, having enough sleep and relaxation, and maintaining a generally cheerful attitude.  

Dr. Tressillian Fere’s cancer treatment also included a constant regimen of medicine made up of treatments such as iodine, stock vinegar, and acidulated water. She points out that these things are natural chemicals as opposed to drugs.  

Further Reading & References  

• Does Diet Cure Cancer? by Maud Tresillian Fere  

Dr. Johanna Budwig/Flaxseed Oil & Cottage Cheese (FOCC)  

Dr. Johanna Budwig, a German physician and seven-time alternative Nobel Prize nominee, created what is now called the “Budwig Protocol” as a way to cure cancer. It mainly consists of a three-month flax oil-quark program, which is a combination diet of whole flaxseeds, flaxseed oil, and low-fat organic cottage cheese (known in Europe as “quark”).  

The Budwig diet includes a long list of other recommended foods such as herbs, nuts, cocoa, and tea. She also provided a list of foods to stay away from, which include hydrogenated oils, hard-shell seafood, white breads, and soy products.  

The Budwig program replenishes cells that are devoid of essential fats and oils, thereby allowing them to function once again. In turn, this leads to healing and recovery from a number of degenerative diseases including cancer.  

Dr. Budwig held that cancer was caused by one of four things: a weak immune system, toxins, an improper diet, or oxygen deprivation (or a combination of any of these things).  

Dr. Budwig states in her book, Flax Oil As a True Aid Against Arthritis, Heart Infarction, Cancer, and Other Diseases:  

“I often take very sick cancer patients away from hospital where they are said to have only a few days left to live, or perhaps only a few hours. This is mostly accompanied by very good results…in the hospital it was said that they could no longer urinate or produce bowel movements. They suffered from dry coughing without being able to bring up any mucous. Everything was blocked. It greatly encourages them when suddenly the …fats with their wealth of electrons, start reactivating the vital functions and the patient immediately begins to feel better.”  

After three decades of research Dr. Budwig, a seven-time Nobel Prize nominee, found that the blood of seriously ill cancer patients was always, without exception, deficient in certain important essential ingredients such as phosphatides and lipoproteins. The blood of a healthy person always contains sufficient quantities of these essential ingredients. However, without these natural ingredients cancer cells grow wild and out of control.  

In the course of her research, blood analysis showed a strange greenish-yellow substance in place of the healthy red oxygen carrying hemoglobin that belongs there. This explained why cancer patients weaken and become anemic. This startling discovery led Dr. Budwig to test her theory. She found that when these natural ingredients were replenished over approximately a three-month period, tumors gradually receded. The strange greenish elements in the blood were replaced with healthy red blood cells as the phosphatides and lipoproteins almost miraculously reappeared. Weakness and anemia disappeared and life energy was restored. Symptoms of cancer, liver dysfunction and diabetes were completely alleviated.  

Dr. Budwig then discovered an all-natural way for people to replace those essential ingredients in their bodies. Eating organic flaxseed oil & cottage cheese together made for an effective natural remedy since each triggers the release of the healing properties of the other.  

In the mid 1950′s, Dr. Budwig began her long and meticulous research on the importance of essential fatty acids (linoleic and linolenic) in the diet.  

Her subsequent discoveries and announcements sparked mixed reactions. While the general public was eager for this information, German manufacturers of commercial dietary fats (margarine, hard shortening, vegetable oils) went to extremes to prevent her from publishing her findings.  

Dr. Budwig preached against the use of these fats, which she called “pseudo” fats. In order to extend the shelf life of their products, manufacturers use chemical processes that render their food products harmful to the body. These harmful fats go by a number of names, including “hydrogenated,” “partially hydrogenated,” and even “polyunsaturated.”  

More than 50 years later, it has now become widely accepted that the hydrogenated “trans fats” made by these manufactures are profoundly harmful. There is no question that Dr. Budwig was right about this subject, yet her other findings, especially those concerning the benefit of the flaxseed oil/cottage cheese mixture, have not gained acceptance despite the testimony of many patients who controlled or reversed their cancers using the Budwig Protocol.  

The chemical processing of fats destroys the vital electron cloud within the fat. Once the electrons have been removed, these fats can no longer bind with oxygen, and they actually become a harmful substance deposited within the body. The heart, for instance, rejects these fats and they end up as inorganic fatty deposits on the heart muscle itself.  

Chemically processed fats are not water-soluble when bound to protein. They end up blocking circulation, damage heart action, inhibit cell renewal, and impede the free flow of blood and lymph fluids. The bioelectrical action in these areas slows down and may become completely paralyzed. The entire organism shows a measurable loss of electrical energy which is replenished only by adding active lipids to the diet. These nutritional fats are vital.  

Science has proven that fats play an important role in the functioning of the entire body. Fats (lipids) are vital for all growth processing, renewal of cells, brain and nerve functions, sensory organs (eyes and ears), and for the body’s adjustment to heat, cold, and quick temperature changes. Our energy resources are based on lipid metabolism. To function efficiently, cells require true polyunsaturated, live electron-rich lipids, present in abundance in raw flaxseed oil. True polyunsaturated fats greedily absorb proteins and oxygen and pump them through the system.  

Lipids are only water-soluble and free-flowing when bound to protein; thus the importance of protein-rich cottage cheese. When high quality, electron-rich fats are combined with proteins, the electrons are protected until the body requires energy. This energy source is then fully and immediately available to the body on demand, as nature intended.  

Dr. Roehm, an oncologist, stated in the July 1990 issue of the Townsend Letter for Doctors:  

“What Dr. Johanna Budwig has demonstrated to my initial disbelief but lately, to my complete satisfaction in my practice is: CANCER IS EASILY CURABLE, the treatment is dietary/lifestyle, the response is immediate; the cancer cell is weak and vulnerable; the precise biochemical breakdown point was identified by her in 1951 and is specifically correctable.”  

Dr. Roehm further claimed:  

“… this diet is far and away the most successful anti-cancer diet in the world.”  

General Rules for the Budwig Diet:  

• The patient has no nourishment on Day 1 other than 250 ml (8.5 oz) of flax oil with honey plus freshly squeezed fruit juices (no sugar added!). In the case of a very ill person, champagne may be added on the first day in place of juice and is taken with the flax oil and honey. Champagne is easily absorbable and has a serious purpose here.  
• Sugar is absolutely forbidden. Grape juice may be added to sweeten any other freshly squeezed juices.  

• Other forbidden foods are:  

• All animal fats.  
• All Salad Oils (this includes commercial mayonnaise)  

• All Meats (chemicals & hormones)  
• Butter  
• Margarine  
• Preserved Meats (the preservatives block metabolism even of flax oil)  

• Freshly squeezed vegetable (and certain fruit) juices are fine – carrot, celery, apple, and red beet.  

• Three times daily a warm tea is essential – peppermint, rose hips or grape tea – all sweetened as desired with honey. One cup of black tea before noon is fine.  

Daily Plan:  

• Before breakfast – a glass of acidophilus milk or sauerkraut juice is taken.  
• Breakfast – Muesli (regular cereal) is topped with 2 tablespoons (30 ml) of flax oil and honey and fresh fruit according to season – berries, cherries, apricots, peaches, grated apple. Vary the flavor from day to day. Use any nuts except peanuts. Herbal teas as desired or black tea. A 4 oz (120 g) serving of “The Spread” (directions below). This is fine to eat straight like a custard, or add it to other foods taken in the day as you will see.  
• Morning snack (10am) – A glass of fresh carrot juice, apple, celery, or beet-apple juice is taken.  

• Lunch – Raw salad with yoghurt-flax oil mayonnaise (directions below).  
• In addition to green salads, use grated turnips, carrots, kohlrabi, radishes, sauerkraut, or cauliflower. A fine powder of horseradish, chives, or parsley may be added for flavor.  
• Cooked meal course – steamed vegetables, potatoes, or such grains as rice, buckwheat, or millet may be served. To these add either “The Spread” (see below) or “The Mayo” (see below) – for flavor and to increase your intake of flax oil. Also, mix “The Spread” with potatoes for an especially hearty meal. Add caraway, chives, parsley, or other herbs.  
• Dessert – Mix fresh fruit other than those used for breakfast with “The Spread,” this time (instead of honey), flavor using cream of lemon, vanilla, or berries.  
• Afternoon snack (4pm) – a small glass of natural wine (no preservatives) or champagne or fresh fruit juice with 1-2 tablespoons of honey-coated flax seeds.  

• Dinner – have this early, at 6pm. Make a hot meal using buckwheat, oat, or soy cakes. Grits from buckwheat are the very best and can be placed in a vegetable soup, or in a more solid form of cakes with herbal sauce. Sweet sauces & soups can always be given more healing energy by adding “The Spread.” Only honey or grape juice can be used for sweeteners. NO white sugar (or brown!) Only freshly squeezed juices and NOT reconstituted juices (preservative danger) may be used. These must be completely natural.  

How to prepare The Spread:  

• Place 250 ml (8.5 oz) flaxseed oil into a mixer bowl and add one pound (450 g) of 1% cottage cheese (i.e. low fat Quark) and add 4 tablespoons (60 ml) of Honey. Turn on the mixer and add just enough low fat milk or water to get the contents of the bowl to blend in together. In 5 minutes, a preparation of custard consistency results that has NO taste of the oil (and no oily ‘ring’ should be seen when you rinse out the bowl).  
• Alternatively, you can use yogurt instead of cottage cheese in proportions of 1 oz (30 g) of yogurt to 1 tablespoon (15 ml) each of flaxseed oil and of honey and blend as above. Note: When flaxseed oil is blended like this, it does not cause diarrhea even when given in large amounts. It reacts chemically with the (sulphur) proteins of the cottage cheese, yoghurt, etc.  

How to prepare the Mayonnaise:  

• Mix together 2 tablespoons (30 ml) flaxseed Oil, 2 tablespoons (30 ml) milk, and 2 tablespoons (30 ml) yogurt.  
• Then add 2 tablespoons (30 ml) of lemon juice (or apple cider vinegar) and add 1 teaspoon (2.5g) of mustard plus some herbs such as marjoram or dill.  
• Next, add 2 or 3 slices of health food store pickles (no preservatives – read the label) and a pinch of herbal salts.  

You will have to remain on this diet for a good five years, at which time your tumor may have disappeared. Persons who break the rules of this diet, Dr. Budwig reports, (i.e., eating preserved meats, candy, etc) will sometimes grow rapidly worse and cannot be saved after they come back from their spree.  

In 1967, Dr. Budwig broadcast the following statement during an interview over the South German Radio Network, describing her incoming patients with failed operations and x-ray therapy:  

“Even in these cases it is possible to restore health in a few months at most, I would truly say 90% of the time.  

“This has never been contradicted, but this knowledge has been a long time reaching this side of the ocean, hasn’t it? Cancer treatment can be very simple and very successful once you know how. The cancer interests don’t want you to know this. May those of you who have suffered from this disease (and I include your family and friends in this) forgive the miscreants who have kept this simple information from reaching you for so long.”  

It is believed Dr. Budwig was referring to people above who had NOT previously been treated with radiation or chemotherapy. Flaxseed oil is readily denatured by oxygen, heat, and light. That’s why it is used in paint. Rancid oil is bad for health, so the flax oil MUST be carefully produced, packed under nitrogen in lightproof containers, refrigerated until used, used as fresh as possible, and promptly stabilized with protein once the container is opened.  

Flaxseeds may also be used. Seeds need only be cracked in a food blender, or they may be ground in a coffee grinder. One needs three times the amount of seeds to get the oil equivalent. The seeds are also high in soluble fiber, so blending with liquid tends to produce ever-hardening “jellies.” Fresh-cracked seed sprinkled on muesli & eaten promptly tastes great.  

At one time, Dr. Budwig served as the Central Government’s Senior Expert for fats and pharmaceutical drugs in Germany, therefore giving her a reputation during her life as one of the world’s leading authorities on fats and oils. She held that the trans fats used in most deep-fried and processed foods actually work to suffocate cells. By depriving those cells of life-giving oxygen, the result is chronic or terminal disease.  

Dr. Budwig held very strongly that her treatment regime could successfully treat cancer. Her views on trans fats, once controversial, are now accepted everywhere. She had 50 years of successes spanning over 2,400 people with cancer and other diseases to back up her claim.  

There are variations of the above protocol which are reportedly effective, and some leading alternative cancer clinics and doctors will encourage their patients to use the flaxseed oil/cottage cheese mixture along with other therapies.  

Bill Henderson, perhaps North America’s leading advocate of the Budwig Protocol, offers this recipe:  

“One-third of a cup of flaxseed oil mixed with two-thirds of a cup of cottage cheese. Add berries, almonds and walnuts and a little stevia [optional] in the blender. Add a little fresh water. Adjust to taste. Blend on the ‘liquefy’ setting. Eat it as soon as it’s blended. Order flaxseed oil from Barleans at 800-445-3529 or www.barleans.com . When you’ve gotten rid of your cancer you can scale back to a maintenance dose, which cuts the amount of flaxseed oil and cottage cheese in half.” He adds that “Stirring isn’t good enough. To mix it properly, you have to blend it. . .You may have heard that dairy products are bad for cancer patients, and I would agree with that. But when you mix cottage cheese with flax oil, it loses its dairy property. Dozens of people I know who are lactose-intolerant eat the Budwig protocol every day without any problems whatsoever.” SOURCE: Alternative Cancer Research Institute 

Henderson’s Special Report, How to Cure Almost Any Cancer at Home for $5.15 a Day, is available at www.cancerdefeatedpublications. com .  

Further Reading & References  

• Flax Oil As a True Aid Against Arthritis, Heart Infarction, Cancer, and Other Diseases by Dr. Johanna Budwig  
• Cancer: The Problem and the Solution by Dr. Johanna Budwig  
• The Oil Protein Diet Cookbook by Dr. Johanna Budwig  
• Budwig Center: http://www.budwigcenter.com/  

• Health and Well-Being, featuring Dr. Johanna Budwig: http://www.lightsv.org/bud1.htm  
• Roehm, Townsend Letter for Doctors, July 1990  
• “Promotion and Prevention of Tumour Growth Effects of Endotoxin, Inflamation, and Dietary Lipids”, by Raymond Kearney, Ph.D, Department of Infectious Diseases, The University of Sydney, Sydney, N.S.W. 2006 Australia. International Clinical Nutrition Review, October, 1987 Vol. 7, No. 4.  

Dr. Hulda Clark Ph.D.,N.D., was an independent research scientist specializing in biology, biophysics and cell physiology. In 1979, Dr. Clark left government research to begin private consulting full-time and in 1985 developed a radio electronic technique for scanning the human body, the Syncrometer, which tests for viruses, bacteria, fungi, parasites, solvents and toxins. This gave her clues to the cause of cancer, HIV and other diseases. Her health books are best sellers—at one time they were in the top 3% of books sold on Amazon.com.  

Her theories are based on the simple idea that the human body heals itself if kept in good condition. No matter how many symptoms a person has, she attributes them to only two causes of health problems:  

• Pollutants (toxins which make it difficult for organs to do their work—especially isopropyl alcohol)  
• Parasites (protozoa, amoeba, worms that utilize our food and leave us with their wastes).  

• Parasites – electronic and herbal treatment  
• Pollution – avoidance  

Her solution to good health is as follows: Her strategy to return to health is:  

• Kill all parasites, bacteria, viruses, and fungi.  
• Remove toxic molds, metals and chemicals from food and body products.  

• Clear and wash away gallstones, secretions and debris already formed that hinder healing.  
• Use herbs and special food factors to hasten healing, being careful to use only unpolluted products.  

Hulda Clark is more concerned with the food that’s free from parasites, bacteria and chemicals rather than with the style of nutrition or lack thereof in dealing with cancer. Her approach is different from those who specialize in cancer-controlling foods and nutrition.  

Flatworms, roundworms, protozoa, bacteria, and viruses are killed using a combination of an electronic device called a ‘zapper’ and an herbal parasite killing program. Dr. Clark has found that this can benefit almost every illness. The zapper is a handheld battery operated (9V) frequency generator that uses a positively offset square wave to electrocute parasites. Its effectiveness is believed to be because it regenerates the white blood cells by building a positive magnetic field in the body. It is a recognized medical device, but should not be used by people with pacemakers or by pregnant women. (See Zappers.)  

The herbal program kills remaining parasites throughout the body which cannot be reached by the electric current. It consists of black walnut hull tincture, wormwood capsules, and cloves taken over 3 weeks. A weekly maintenance program is then recommended to prevent reinfection from the home, pets, undercooked dairy products and undercooked meat. She believed uncooked meat is the main source of intestinal flukes.  

She contended that isopropyl alcohol is a key pollutant. Foods and products polluted with isopropyl alcohol include shampoo, hair spray and mousse, cold cereals, cosmetics, mouthwash, decaffeinated coffee, vitamins, minerals and supplements, bottled water (polluted with antiseptics from the bottling procedure), rubbing alcohol, white sugar, shaving supplies, carbonated beverages and store-bought fruit juice. Dr. Clark recommends homemade products, unprocessed foods and a limited number of tested supplements. Once you stop using isopropyl alcohol, it disappears from your body within three days.  

When isopropyl alcohol is present in the body, the intestinal fluke uses another organ as a secondary host and that organ becomes cancerous. Other solvents in the body produce other diseases. For example, benzene causes the intestinal fluke to use the thymus for its secondary host, ruins the immune system and AIDS develops. Wood alcohol invites pancreatic flukes to use the pancreas as a secondary host and diabetes develops. Dr. Clark states that cancer could be eliminated if laws required testing for solvents in animal feeds and human foods. A significant reason for isopropyl alcohol pollution is the chemicals used by manufacturers to sterilize food-handling equipment.  

After cancer is stopped, the patient can get well if the toxins that invited parasites, bacterial, and viral invaders are removed. Removing toxins from the affected organs lets them heal. For example, lung lesions will not heal unless cigarette smoking, Freon, asbestos, and fiberglass exposure is stopped.  

Carcinogens draw the cancer to the organ: nickel draws cancer to the prostate, barium draws cancer to the breast. Dr. Clark considers the most serious threats to be: Freon (CFCs or refrigerant), copper from water pipes, fiberglass or asbestos, mercury from amalgam tooth fillings, lead from joints in copper plumbing, formaldehyde in foam bedding and new clothing, and nickel, usually from dental metal.  

Dental, diet, body, and home clean-ups aim to remove parasites and pollutants at their source. The body constantly fights to remove pollutants, but if you are being “re-supplied” with them, the body cannot heal. See Dr. Clark Cleanups.  

The dental clean up has been found crucial in shrinking tumors and restoring health. This is subject on which many alternative cancer experts agree. Dr. Clark advises:  

• Remove all metals and large plastic fillings from the mouth.  
• Remove all infected teeth and clean cavitations.  

Silver or amalgam fillings contain 48-55% mercury, 33-35% silver, and various amounts of copper, tin, zinc, and other metals that corrode and seep into the body. Mercury is continually released from mercury fillings in the form of mercury vapor and abraded particles, which can be increased 15-fold by chewing, brushing, and hot liquids. Research has shown that mercury, even in small amounts, damages the brain, heart, lungs, liver, kidneys, thyroid, pituitary and adrenal glands, blood cells, enzymes, and hormones, and suppresses the body’s immune system.  

At the beginning of the 20th century Dr. Weston Price, head of the American Dental Association, found that root canal therapy, often used to save a tooth that has become infected or dead, had serious side effects. He showed thousands of instances of disease created from devitalized (i.e. dead) teeth, from head and neck pain to rheumatism and cancer. Most patients with devitalized teeth had thyroid dysfunction. The dental establishment, heavily committed to mercury amalgam fillings and root canals, ignored his findings. Safe treatment requires extracting the dead tooth rather than filling the root, and removing any infected tissue from around the tooth. Later the space can be filled with a bridge or partial denture.  

Personal care products — particularly petroleum products, alcohol, asbestos, colorings, dyes, formaldehyde, and perfume—are often toxic. These chemicals were not in use fifty or sixty years ago. Likewise for many other substances that have found their way into the human body. The tested ingredients in 99% of perfumes are labeled as toxic hazards and are not allowed in the agriculture industry. So, apart from avoidance of processed foods, Dr. Clark warns against commercial salves, ointments, lotions, colognes, perfumes, deodorants, toothpaste, soaps, washing powders etc. and gives recipes for homemade substitutes, e.g. borax powder for cleaning.  

Cleaning up the home environment to make it safe includes:  

• Removing paints, varnishes, thinners, cleaners, and chemicals from the house.  
• Sealing cracks around pipes.  
• Changing CFC-cooled refrigerators for non CFC ones (Dr. Clark found Freon concentrated in cancerous organs, where it facilitates the accumulation of other toxins).  

• Checking air conditioners for leaks.  
• Sealing or removing uncovered fiberglass.  
• Removing clothes dryers, hair dryers containing asbestos and old radiators and electric heaters which give off asbestos.  
• Changing copper plumbing to PVC plastic.  

She suggests if you have been quite ill to move to a warm climate where you can avoid heating and cooling, and spend more time outdoors.  

Clark recommended the Syncrometer, a device that makes it possible to test exactly which toxins and parasites cause a patient’s cancer. The Syncrometer can be used for diagnosing and monitoring progress until cured. It consists of an audio oscillator circuit, which includes the body as part of the circuit. Dr. Clark maintained that every living and non-living entity produced certain specific frequencies which can be heard with the audio oscillator. Every living creature broadcasts its presence like a radio station.  

The Syncrometer tests for parasites or pollutants in any product or body tissue by using samples of those parasites or pollutants. Cancerous tumors grow in the body for at least three years before they are big enough to be detected by medical imaging techniques, but according to advocates, the Syncrometer can detect them long before that.  

For detoxifying the body, Dr. Clark recommends vitamins, minerals, and herbs from safe sources. Apart from parasite and dental cleanses, she gives detailed instructions for liver, kidney, and bowel cleanses. She recommends that the liver cleanse should not be done if the liver contains living parasites, and is best carried out after a parasite cleanse and then a kidney cleanse. The liver cleanse is reportedly the single most important thing you can do for your health. Medical herbalists, naturopaths and other natural healers speak highly of her cleanses.  

Thousands of testimonials exist acclaiming her methods and the success people have achieved through using them. A booklet of a thousand testimonials is available for $10 from the Dr. Clark Information Center, located at http://www.drclark.net/.  See Dr. Clark Cleanups. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

• The Cure for All Diseases by Hulda Regehr Clark (1995)  
• The Cure For All Advanced Cancers by Hulda Regehr Clark (1999)  
• The Cure for All Cancers: Including over 100 Case Histories of Persons Cured by Hulda Regehr Clark (1993)  
• The Cure and Prevention of all Cancers by Hulda Regehr Clark (2008)  
• The Cure For HIV / AIDS by Hulda Regehr Clark (2002)  

• Syncrometer Science Laboratory Manual by Hulda Regehr Clark (2000)  
• “University of Washington study shows the Dr. Clark zapper inhibits the growth of leukemia cells’”  
• Dr. Clark Information Center, http://www.drclark.net/news/lairesearch.htm  

William D. Kelley, DDS was a dentist who claimed to have healed himself of pancreatic cancer with his own therapy in 1964. The Kelley Anti-Cancer Program combines therapeutic nutrition, supplements, and vigorous detoxification of the body. His healing program was based on metabolic typing with the goal of providing a patient-specific dietary program, detoxification (using coffee enemas —a recognized detoxification therapy—and other therapies), neurological stimulation through chiropractic adjustment, and supplements of vitamins, minerals, and enzymes.  

Dr. Kelley believed the root cause of cancer is the body’s inability to digest and utilize (essentially, metabolize) protein. He stated: “The person gets cancer because he’s not properly metabolizing the protein in his diet. Then, to make matters worse, the tumor has such a high metabolism that it uses up much of the food which is eaten.  

“If a person’s disordered protein metabolism is not corrected it will give rise to more tumors in the future, even if the first one is successfully removed. This, by the way, is the unfortunate reason why so many seemingly successful cancer operations end up in recurrences a year or two later. The tumor was removed, but the cause—improper protein metabolism—remained.”  

Dr. Kelley linked faulty metabolism to a deficiency of pancreatic enzymes which he regarded as a fundamental cause of cancer. He believed that certain pancreatic enzymes, especially those that are proteolytic (protein-digesting) enzymes, are the body’s first line of defense against malignancy. This theory stands in marked contrast to the view that the immune system, with its natural killer cells, is the body’s main line of defense against cancer. (See Proteolytic Enzymes.)  

The pancreas releases enzymes directly into the small intestine to aid digestion. But Kelley maintained that the pancreas also secretes enzymes into the bloodstream, where they circulate, reaching all body tissues, and killing cancer cells by digesting them. Studies in the clinical literature lend support to this theory, first proposed by Dr. John Beard, a Scottish embryologist working at the turn of the century.  

Imbalance of mineral metabolism is another condition that allows malignancy to occur, according to Dr. Kelley. He identified mineral imbalance as a root cause of the breakdown of the immune system.  

Additionally, he said, cancer cells produce immune-blocking factors and seem to generate an electromagnetic force field that inhibits the proper response of the immune system.  

To demonstrate his theories, Kelley divided people into what he called ten metabolic types, with slow-oxidizing vegetarians at one extreme and fast-oxidizing carnivores at the other. Each person is different, he asserted, not only in nutritional needs but also in the way their bodies use food.  

Kelley then recommended a different nutritional program for each of the ten different metabolic types. An individualized diet was tailored to match the metabolic character of each patient, taking into account his or her physiology, neurological and physical makeup, basic metabolic rate, and personality. Some common threads ran through the diets, however. The consumption of raw, organic fruits, and vegetables was emphasized, while protein intake was reduced considerably to preserve the enzymes needed to digest fruits and vegetables.  

In addition to a diet, Kelley’s patients also took as many as 150 supplement pills per day, including pancreatic enzymes, vitamins and minerals, and concentrates of raw beef or organs and glands, believed by Kelley to contain tissue-specific growth factors, hormones, natural stimulants, and protective molecules. A direct anti-tumor effect has been observed repeatedly in patients on various metabolic therapies, who receive enzymes either orally or by injection. According to Kelley, as the enzymes “digest” the tumor, large amounts of cellular debris are released into the bloodstream and surrounding tissues.  

These breakdown products from cancer cells are foreign to the normal body and can be very toxic, he maintained. Even though the liver and kidney can filter these substances out of the bloodstream, the wastes from tumor destruction form so quickly during enzyme therapy that the body’s normal detoxification processes may become overloaded. To assist their bodies in detoxification, Kelley’s patients periodically discontinued their enzymes and other supplements for several days. 

This rest period, Kelley believed, allows the liver and kidneys to catch up with the body’s load of tumor byproducts.  

As a second aid in detoxification, Kelley advised all his patients to take at least one coffee enema daily.  

His reasoning was that coffee enemas clean out the liver and gallbladder and help the body get rid of the toxins produced during tumor breakdown. During a coffee enema, claimed Kelley, the caffeine that is rapidly absorbed in the large intestine flows quickly into the liver. He believed that in high enough concentrations, caffeine causes the liver and gallbladder to contract vigorously, releasing large amounts of stored wastes into the intestinal tract and greatly aiding elimination. Kelley also believed that enemas are important in stimulating the immune system, since most waste products eliminated by detoxification are enzyme inhibitors. Frequent enemas prevent the suppression of protein-digesting enzymes.  

These enzymes can break down the cancer cells’ fibrin (protein) coats, making the cancer cells more vulnerable to the immune system. See Coffee Enemas.  

The Merck Medical Manual, commonly thought to be the “bible of physicians”, included coffee enemas as an accepted means of detoxification and constipation relief up through 1977. Despite that, coffee enemas, common also to the Gerson Therapy, became the focal point of opponents who considered Kelley’s program unscientific.  

The original Kelley program also included purges to cleanse the liver, gallbladder, intestines, kidneys, and lungs. Like many other metabolic therapists, Kelley believed that the functioning of these organs is severely impaired in the cancer patient. Colonic irrigations, liver and gallbladder flushes, and controlled sweating accomplished the cleansing tasks. Kelley also often recommended some form of manipulative therapy, such as chiropractic adjustment or osteopathic manipulation, to stimulate sluggish nerves.  

A frequently overlooked part of the Kelley system is its spiritual component. Kelley called his approach metabolic ecology, taking into account the cancer patient’s total environment, including physical, mental, emotional, and spiritual aspects. He urged his patients to “accept the fact that you are afflicted with a symptom (malignant cancer) and that recovery is possible. Establish a faith in a power greater than yourself and know that with His help you can regain health and harmony.”  

Patients were encouraged to conduct a searching self-analysis and to eliminate negative behavioral patterns and emotions.  

The Kelley approach boasts extensive documentation with 10,000 medically-verified diagnoses. In one study, all his cases of pancreatic cancer were investigated. With conventional treatment, there were virtually no survivors after 5 years. He had 22 cases on record. Of these, 10 never started the treatment and survived for 67 days. 7 followed it partially and survived an average of 233 days, while the 5 who followed the Kelley treatment all completely recovered.  

Interest in Kelley’s therapy has increased dramatically in recent years largely due to the work of Nicholas Gonzalez, M.D., a New York City physician who treats cancer patients in advanced or terminal stages using a modified version of the Kelley program. A graduate of Cornell University Medical School, Dr. Gonzalez undertook a five-year case study of cancer patients of Kelley’s who did well on the program.  

The late Harold Ladas, Ph.D., a biologist and former professor at Hunter College, wrote:  

“Gonzalez has given us convincing evidence that diet and nutrition produce long-term remission in cancer patients almost all of whom were beyond conventional help.  

“Because the cases [in Gonzalez’s study] represent a wide variety of cancers, the implication is that the paradigm has wide applicability to cancer treatment. …What should happen is that ACS [American Cancer Society] or NCI [National Cancer Institute] should immediately follow up with a half million dollar study to evaluate the rest of Kelley’s cancer patients. But don’t hold your breath,” added Ladas, who concluded, “The evidence is in, and it is stunning. Kelley is vindicated.”  

In 1987, Dr. Gonzalez set up a private practice in New York City, where he began treating patients with a modified version of Dr. Kelley’s program.  

A pilot study of Dr. Gonzales treatment in patients with advanced pancreatic cancer was published in 1999. Of the 11 patients included in the study, 9 survived at least 1 year, 5 survived for 2 years, and 4 lived for 3 years. Two of the patients remained alive 4 years later. In contrast, the median survival for patients with inoperable pancreatic cancer who undergo chemotherapy is 5 ½ months. A further clinical study involving patients diagnosed with pancreatic cancer is expected.  

Like Kelley, whom the American Cancer Society denounced as a quack, Gonzalez has also been castigated for “departing from accepted practice.”  Dr. Gonzales program and its theory are described at http://dr-gonzalez.com/ . SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

• One Answer to Cancer by William D. Kelley, http://www.drkelley.com/  
• Dr. William D. Kelly’s Nutritional-Metabolic Therapy, http://educate-yourself.org/cancer/ kellysmetabolictherapy.shtml  
• Dr. Gonzalez: Individualized Nutritional Protocols, http://dr-gonzalez.com/  
• The Alternative Cancer Therapy Book by Richard Walters (1993)