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What is photodynamic therapy?

Photodynamic therapy (PDT) is a treatment that uses a drug, called a photosensitizer or photosensitizing agent, and a particular type of light. When photosensitizers are exposed to a specific wavelength of light, they produce a form of oxygen that kills nearby cells (13).

Each photosensitizer is activated by light of a specific wavelength (3, 4). This wavelength determines how far the light can travel into the body (3, 5). Thus, doctors use specific photosensitizers and wavelengths of light to treat different areas of the body with PDT.

Key Points

  • Photodynamic therapy (PDT) combines a drug (called a photosensitizer or photosensitizing agent) with a specific type of light to kill cancer cells.
  • The U.S. Food and Drug Administration has approved the photosensitizing agent called porfimer sodium, or Photofrin®, for use in PDT to treat or relieve the symptoms of certain cancers.
  • Patients treated with porfimer sodium should avoid direct sunlight and bright indoor light for at least 6 weeks after treatment.
  • Researchers continue to study ways to improve the effectiveness of PDT and expand its use to other cancers.

 How is PDT used to treat cancer?

In the first step of PDT for cancer treatment, a photosensitizing agent is injected into the bloodstream. The agent is absorbed by cells all over the body but stays in cancer cells longer than it does in normal cells. Approximately 24 to 72 hours after injection (1), when most of the agent has left normal cells but remains in cancer cells, the tumor is exposed to light. The photosensitizer in the tumor absorbs the light and produces an active form of oxygen that destroys nearby cancer cells (13).

In addition to directly killing cancer cells, PDT appears to shrink or destroy tumors in two other ways (14). The photosensitizer can damage blood vessels in the tumor, thereby preventing the cancer from receiving necessary nutrients. PDT also may activate the immune system to attack the tumor cells.

The light used for PDT can come from a laser or other sources (2, 5). Laser light can be directed through fiber optic cables (thin fibers that transmit light) to deliver light to areas inside the body (2). For example, a fiber optic cable can be inserted through an endoscope (a thin, lighted tube used to look at tissues inside the body) into the lungs or esophagus to treat cancer in these organs. Other light sources include light-emitting diodes (LEDs), which may be used for surface tumors, such as skin cancer (5).

PDT is usually performed as an outpatient procedure (6). PDT may also be repeated and may be used with other therapies, such as surgery, radiation, or chemotherapy (2).

Extracorporeal photopheresis (ECP) is a type of PDT in which a machine is used to collect the patient’s blood cells, treat them outside the body with a photosensitizing agent, expose them to light, and then return them to the patient. The U.S. Food and Drug Administration (FDA) has approved ECP to help lessen the severity of skin symptoms of cutaneous T-cell lymphoma that has not responded to other therapies. Studies are under way to determine if ECP may have some application for other blood cancers, and also to help reduce rejection after transplants.

What types of cancer are currently treated with PDT?

To date, the FDA has approved the photosensitizing agent called porfimer sodium, or Photofrin®, for use in PDT to treat or relieve the symptoms of esophageal cancer and non-small cell lung cancer. Porfimer sodium is approved to relieve symptoms of esophageal cancer when the cancer obstructs the esophagus or when the cancer cannot be satisfactorily treated with laser therapy alone. Porfimer sodium is used to treat non-small cell lung cancer in patients for whom the usual treatments are not appropriate, and to relieve symptoms in patients with non-small cell lung cancer that obstructs the airways. In 2003, the FDA approved porfimer sodium for the treatment of precancerous lesions in patients with Barrett esophagus, a condition that can lead to esophageal cancer.

What are the limitations of PDT?

The light needed to activate most photosensitizers cannot pass through more than about one-third of an inch of tissue (1 centimeter). For this reason, PDT is usually used to treat tumors on or just under the skin or on the lining of internal organs or cavities (3). PDT is also less effective in treating large tumors, because the light cannot pass far into these tumors (2, 3, 6). PDT is a local treatment and generally cannot be used to treat cancer that has spread (metastasized) (6).

Does PDT have any complications or side effects?

Porfimer sodium makes the skin and eyes sensitive to light for approximately 6 weeks after treatment (1, 3, 6). Thus, patients are advised to avoid direct sunlight and bright indoor light for at least 6 weeks.

Photosensitizers tend to build up in tumors and the activating light is focused on the tumor. As a result, damage to healthy tissue is minimal. However, PDT can cause burns, swelling, pain, and scarring in nearby healthy tissue (3). Other side effects of PDT are related to the area that is treated. They can include coughing, trouble swallowing, stomach pain, painful breathing, or shortness of breath; these side effects are usually temporary.

What does the future hold for PDT?

Researchers continue to study ways to improve the effectiveness of PDT and expand it to other cancers. Clinical trials (research studies) are under way to evaluate the use of PDT for cancers of the brain, skin, prostate, cervix, and peritoneal cavity (the space in the abdomen that contains the intestines, stomach, and liver). Other research is focused on the development of photosensitizers that are more powerful (1), more specifically target cancer cells (1, 3, 5), and are activated by light that can penetrate tissue and treat deep or large tumors (2). Researchers are also investigating ways to improve equipment (1) and the delivery of the activating light (5).

Selected References

  1. Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nature Reviews Cancer 2003; 3(5):380–387. [PubMed Abstract]
  2. Wilson BC. Photodynamic therapy for cancer: principles. Canadian Journal of Gastroenterology 2002; 16(6):393–396. [PubMed Abstract]
  3. Vrouenraets MB, Visser GW, Snow GB, van Dongen GA. Basic principles, applications in oncology and improved selectivity of photodynamic therapy. Anticancer Research 2003; 23(1B):505–522. [PubMed Abstract]
  4. Dougherty TJ, Gomer CJ, Henderson BW, et al. Photodynamic therapy. Journal of the National Cancer Institute 1998; 90(12):889–905. [PubMed Abstract]
  5. Gudgin Dickson EF, Goyan RL, Pottier RH. New directions in photodynamic therapy. Cellular and Molecular Biology 2002; 48(8):939–954. [PubMed Abstract]
  6. Capella MA, Capella LS. A light in multidrug resistance: photodynamic treatment of multidrug-resistant tumors. Journal of Biomedical Science 2003; 10(4):361–366. [PubMed Abstract]

Ultraviolet light is known to have antibacterial properties and has been used to sterilize medical equipment.

The healing properties of ultraviolet light were first demonstrated in the 1880s by Niels Ryberg Finsen.

He reportedly provided ultraviolet radiation therapy to patients with skin disease or mucous membrane disease. Finsen and his followers are said to have treated more than 2,000 patients with a success rate of 98%. For that he earned the Nobel Prize in 1903.

In the 1930s, ultraviolet therapy was used as a blood treatment. Physicians would essentially “clean” a patient’s blood by withdrawing a sample, irradiating it with ultraviolet light to kill unwanted particles in the blood, and then re-injecting it back into the patient. The cleansing process was believed to lower infection levels. It also had a side effect of strengthening the patient’s immune system.

From there, ultraviolet light therapy was used successfully in California to cure multiple cases of polio. Despite the positive outcome of the treatment, it was largely abandoned by the medical community once antibiotics were developed.

In the therapy, a small amount of blood, from 60 to 250 CC’s, is drawn from the patient and passed through a chamber where it is exposed to ultraviolet light. The blood is then returned to the patient. To those unfamiliar with the therapy, it’s surprising and counter-intuitive that exposure of such a small amount of blood to UV light can affect the whole patient, even granted that UV light is a known microbe-killer. The amount of blood exposed, and presumably the microbes killed, are a tiny percentage of the whole.

It’s reported that, once stimulated by a UV irradiation of the blood, the immune system continues its activity for hours and sometimes days after the treatment. The number of treatments needed is determined by factors such as the state of the patient’s immune system and the length and seriousness of the illness. The usual treatment is about 30 minutes, and is almost painless.

According to Dr. William Campbell Douglass, II, ultraviolet light therapy has been proven in extensive studies and has a “fabulous” record of safety. He reports it has eased the suffering and prolonged the lives of thousands of patients with cancer and other ailments and that he has personally used it in his practice with excellent results.

In 2007, researchers at Newcastle University in the U.K. devised a way to use ultraviolet light to activate antibodies that then target specific tumors. They begin by coating the surface of an antibody with an organic oil that is photocleavable. This prevents the antibody from being activated within the patient until it is specifically illuminated by ultraviolet light. When that happens, the activated antibody binds to T-cells, triggering them to target the surrounding tissue.

When the antibodies are activated near a tumor, the tumor is killed. This means ultraviolet light therapy can be used to steer antibodies directly toward killing cancer tumors, thus sparing attack on healthy tissue and resulting in fewer side effects.

Professor Colin Self, one of the lead researchers in the study, describes the treatment as ” … the equivalent of ultra-specific magic bullets. This could mean that a patient coming in for treatment of bladder cancer would receive an injection of the cloaked antibodies. She would sit in the waiting room for an hour and then come back in for treatment by light. Just a few minutes of the light therapy directed at the region of the tumor would activate the T-cells causing her body’s own immune system to attack the tumor.”

Today, ultraviolet light therapy is said to be a common treatment for multiple ailments in Russia, where drugs are expensive and hospital budgets are severely limited.

The American College for Advancement in Medicine (ACAM) retains a list of doctors who offer this treatment. SOURCE: Alternative Cancer Research Institute

Further Reading & References

  • Light directed activation of Human T-Cells. Colin H. Self, Alexander C. Self, Jacqueline A. Smith, David J. Self and Stephen Thompson. Journal of ChemMedChem. 2007.
  • Light activation of anti-CD3 in vivo reduces the growth of an aggressive ovarian carcinoma, Stephen Thompson, Robert Stewart, Jacqueline A. Smith and Colin Self. Journal of ChemMedChem. 2007.
  • Hidden and Forbidden but for REAL: Medical Miracles Nobody Told You About, by Dr. William Campbell Douglass, II
  • UV Light Improving Chances of Fighting Cancer, Science Daily, 3 Nov. 2007,
  • The Nobel Prize in Physiology or Medicine, 1903: Niels Ryberg Finsen,
Treating Cancer & Destroying Tumors w/ Baking Soda (Sodium Bicarbonate)

An Italian oncologist, Dr. Tullio Simoncini, has devised a simple, very inexpensive and apparently frequently effective cancer treatment centered around the use of sodium bicarbonate, taken orally or by infusion. This baking soda treatment is based on the revolutionary thesis that “Cancer Is a Fungus” (also the title of Dr. Simoncini’s book). Sodium bicarbonate administered directly on the neoplastic masses is said to destroy the fungal colonies lying at the “heart” of the tumor. Additionally, according to Dr. Tullio Simoncini, this baking soda treatment could even be self-applied in certain types of cancer, i.e. if the cancer is limited to the organ (not infiltrating the confined [probably meaning “surrounding/adjacent”] tissue, for example in the oral cavity, oesophagus, stomach, intestine, rectum. The supervision of a doctor, however, is indicated. In all other cases the assistance of a doctor is mandatory (to administer the infusions etc.). 

On success rates and application of sodium bicarbonate therapy 

Dr. Simoncini reports on cases of brain tumors (“both primary and metastatic in general regress or stop growing after therapy with sodium bicarbonate at five per cent solution”), intestinal cancer, bladder cancer, breast cancer, cancer of the spleen, liver cancer, lung cancer, oropharyngeal cancer (mouth, tongue, palate, pharynx), peritoneal carcinosis, pleura tumor (“primary or secondary pleuric neoplasias are amongst the easiest to treat with the therapy method”), prostate tumor, stomach cancer (“one of the tumors that are easiest to treat because of its easily reachable position through the mouth”), tumor of the pancreas and others. This includes successes, sometimes long-term (up to 20 years* when to my knowledge Dr. Simoncini started using this treatment), as well as other less successful experiences and outcomes. Dr. Simoncini gives the following statistics: if the fungi are sensitive to the sodium bicarbonate solutions and the tumour size is below 3 cm, the percentage will be around 90%, in terminal cases where the patient is in reasonably good condition it is 50%, and for terminal patients it is a small percentage.  

And according to Mark Sircus, Ac., OMD, Director of the International Medical Veritas Association, “Dr. Simoncini routinely administers glucose with his IV treatments and this is the best indication for the use of either honey, maple syrup** or black strap molasses** especially for late stage cancer patients whose cells are starving.” 

* See for example these excerpts from a lung cancer case featured at Dr. Simoncini’s site “The therapeutic treatment is based on two essential elements: liver detoxification simultaneously with administration of bicarbonate salts orally, through aerosol and intravenously. After about eight months of bloodless and painless therapy, the mass completely disappears. Over one year after the end of the therapy, the x-rays show only a thickening of the inter-lobe separation, which is the result of healing. The patient is still alive some 20 years after the therapy.” Incidentally, the related Country doctor cures cancer – with baking soda & maple syrup also features a case of lung cancer cure attributed to sodium bicarbonate (plus maple syrup) 

** Compare Country doctor cures cancer – with baking soda & maple syrup and Prostate cancer with osseous metastases testimonial. . 

An interesting interview with Dr. Simoncini can be seen on Doug Kaufmann’s site 

The same site also features a very impressive before-and-after video showing visual proof of a man with basal cell skin cancer (melanoma) of the skalp who was treated by Dr. Simoncini. His melanoma had grown 1 cm deep into his scalp. After treatment with iodine tincture (another anti-fungal agent used by Dr. Simoncini*) and “feeding the skin with a special thermal bath” the melanoma was healed after just 1 1/2 months. 

For a different way someone healed himself of (actually “terminal” malignant melanoma), see this herbal cancer cure testimonial.  

since apparently for skin cancer, Dr. Simoncini says the baking soda is rather ineffective. He recommends to instead paint on red iodine solution in a certain rhythm until the cancer is shed. 

Other cancer and/or health-related applications of sodium bicarbonate 

Baking soda, in addition to its many time-honoured applications (household and other “clean-up” purposes), is also used in baths and rinses for chelating ionizing radiation and/or killing bacteria. 


Since this looks like a promising treatment and fits two of the major ethical criteria of Healing Cancer Naturally (availability to near-everyone due to being inexpensive, low to no toxicity), the reader is encouraged to visit Dr. Simoncini’s site You’ll find much background information and research findings there incl. explanatory videos, a page giving how-to instructions for using sodium bicarbonate, etc. Sodium bicarbonate powder, thanks to its long history of both internal and external use by humans, is available in most any drugstore, supermarket and pharmacy.  

Also see and 

or do a search for more information. Additionally you may find valuable background information in a new (January 2009) yahoo group devoted to the subject of curing cancer with baking soda according to the Simoncini protocol: 

For a simple and inexpensive, promising DIY treatment somewhat comparable in its functioning to sodium bicarbonate, also see MMS® (chlorine dioxide) – a miracle supplement and inexpensive DIY treatment for malaria, cancer, Aids and many other diseases?. 

Important addendum 

This website is about Healing Cancer Holistically since I believe that for true and lasting healing to be achieved on all levels as well as by the same token, to prevent similar or other health crises in the future, it is wisest and best to tackle a cancer and other challenge from several angles. While the dietary/environmental aspects frequently constitute some of the most important ones, the mental/emotional/spiritual ones can also be of major and decisive significance.  

I still include “non-holistic” but highly promising approaches such as Dr. Simoncini’s sodium bicarbonate cancer treatment for all those whom they might benefit in the short or long term. That said, in order to avoid cancer, Dr. Simoncini himself advises “a healthy lifestyle, good (organic) food”, taking as little medicine as possible, exercising and paying “much attention to chronic symptoms.”  

Compare Country doctor cures cancer – with baking soda & maple syrupProstate cancer with osseous metastases testimonial: oral baking soda and blackstrap molasses therapy has helped wipe out bone metastases and reduced PSA to 0.1 

Stem Cell Therapies Today

Did you know that several stem cell therapies are routinely used to treat disease today? 

These include: 

  • Adult Stem Cell Transplant: Bone Marrow Stem Cells  
  • Adult Stem Cell Transplant: Peripheral Blood Stem Cells  
  • Umbilical Cord Blood Stem Cell Transplant 

Adult Stem Cell Transplant: Bone Marrow Stem Cells 

Perhaps the best-known stem cell therapy to date is the bone marrow transplant, which is used to treat leukemia and other types of cancer, as well as various blood disorders. 

Why is this a stem cell therapy?  

Leukemia is a cancer of white blood cells, or leukocytes. Like other blood cells, leukocytes are made in the bone marrow through a process that begins with multipotent adult stem cells. Mature leukocytes are released into the bloodstream, where they work to fight off infections in our bodies.  

Leukemia results when leukocytes begin to grow and function abnormally, becoming cancerous. These abnormal cells cannot fight off infection, and they interfere with the functions of other organs. 

Successful treatment for leukemia depends on getting rid of all the abnormal leukocytes in the patient, allowing healthy ones to grow in their place. One way to do this is through chemotherapy, which uses potent drugs to target and kill the abnormal cells. When chemotherapy alone can’t eliminate them all, physicians sometimes turn to bone marrow transplants. 

In a bone marrow transplant, the patient’s bone marrow stem cells are replaced with those from a healthy, matching donor. To do this, all of the patient’s existing bone marrow and abnormal leukocytes are first killed using a combination of chemotherapy and radiation. Next, a sample of donor bone marrow containing healthy stem cells is introduced into the patient’s bloodstream. 

If the transplant is successful, the stem cells will migrate into the patient’s bone marrow and begin producing new, healthy leukocytes to replace the abnormal cells. 

Adult Stem Cell Transplant: Peripheral Blood Stem Cell Transplant  

While most blood stem cells reside in the bone marrow, a small number are present in the bloodstream. These multipotent peripheral blood stem cells, or PBSCs, can be used just like bone marrow stem cells to treat leukemia, other cancers and various blood disorders. Since they can be obtained from drawn blood, PBSCs are easier to collect than bone marrow stem cells, which must be extracted from within bones. This makes PBSCs a less invasive treatment option than bone marrow stem cells. PBSCs are sparse in the bloodstream, however, so collecting enough to perform a transplant can pose a challenge.  

Umbilical Cord Blood Stem Cell Transplant 

Newborn infants no longer need their umbilical cords, so they have traditionally been discarded as a by-product of the birth process. In recent years, however, the multipotent-stem-cell-rich blood found in the umbilical cord has proven useful in treating the same types of health problems as those treated using bone marrow stem cells and PBSCs. 

Umbilical cord blood stem cell transplants are less prone to rejection than either bone marrow or peripheral blood stem cells. This is probably because the cells have not yet developed the features that can be recognized and attacked by the recipient’s immune system. Also, because umbilical cord blood lacks well-developed immune cells, there is less chance that the transplanted cells will attack the recipient’s body, a problem called graft versus host disease. 

Both the versatility and availability of umbilical cord blood stem cells makes them a potent resource for transplant therapies.  

Source: University of Utah, Genetic Science Learning Center – October 11, 2009 


Supported by a Science Education Partnership Award (SEPA) [No. 1 R25 RR16291-01] from the National Center for Research Resources, a component of the National Institutes of Health, Department of Health and Human Services. The contents provided here are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH. 

About the Gerson Therapy

Gerson Therapy is a whole-body, natural treatment designed to heal the body against cancer, heart disease, allergies, and other illnesses. It was established more than seventy-five years ago by Dr. Max Gerson, and described in detail in his book A Cancer Therapy: Results of Fifty Cases and the Cure of Advanced Cancer.  

Gerson Therapy requires that fresh, organic juices be consumed on a daily basis. The goal is to provide the body with ultra-heavy doses of enzymes, minerals, and other nutrients. This gives the body the ability to break down and eradicate diseased body tissues.  

A typical daily treatment includes thirteen glasses of fresh, raw fruit and vegetable juice, three vegetarian meals, and ample amounts of fresh fruit for dessert and snacks. Medications are included as part of the therapy, all of which are considered organic, biological materials (e.g., Vitamin B12, potassium compound, and pancreatic enzymes, just to name a few). Finally, the therapy includes an important detoxification protocol.  

The diet also includes potassium/iodine supplements. Dr. Gerson stressed the importance of a high potassium content that is more in the skins or outer part of root vegetables than in the centers. Sodium, on the other hand, was to be severely restricted – the diet was completely without added salt but with added potassium salts instead. Dr. Gerson believed an imbalance between sodium and potassium in each cell also contributed to the development of cancer. Therefore, his therapeutic diet excludes sodium and provides abundant potassium.  

Other forbidden foods include salt, oil, berries, nuts, and all bottled, canned, refined, preserved, and processed foods. No aluminum utensils are used, and juices must be pressed.  

In addition, Gerson prescribed hydrochloric acid with pepsin, pancreatinhigh doses of Lugol’s solution (an iodine supplement) together with freeze-dried thyroid, niacin, royal jelly, and injections of vitamin B12 with crude liver.  

In addition, raw liver juice was used for its high content of enzymes. Later, with increasing chemicalization of agriculture, the liver juice was omitted while linseed/flax oil was belatedly added to the list of supplements.  

Liver detoxification with frequent coffee enemas is a cornerstone of the Gerson Therapy; otherwise, patients with advanced cancer might die despite reduction in the size of tumors. Some patients are also given castor-oil enemas and oral and/or rectal hydrogen peroxide and rectal ozone treatment. Dr. Gerson pioneered the use of coffee enemas, which are now widely used in other alternative cancer treatment protocols. Until the 1970s, coffee enemas were listed in the Merck Manual as an accepted mainstream medical treatment. The treatment was apparently removed because the editors lost interest in it, not because it was found to be unsafe or ineffective.  

Dr. Gerson stated:  

“Cancer is not a single cellular problem; it is an accumulation of numerous damaging factors combined in deteriorating the whole metabolism, after the liver has been progressively impaired in its functions. This slow poisoning of the entire organism, a lowering of the electrical activity in vital organs, and the weakening of the liver, the prime organ of detoxification, creates a cancerous body that is anergic.”  

Gerson Therapy is based on the view that malignant growths result from metabolic dysfunction within cells. This was to be countered by diet and detoxification. Gerson felt that, in order to be healed, the body needed to be detoxified with agents that rendered it hypersensitive to abnormal substances (including bacilli and cancer cells), which the body will then eliminate. The more malignant the cells, the more effective the therapy. The Gerson Institute, still open under the direction of Max Gerson’s daughter Charlotte, claims to “cure half of the patients who have a month to live, and 90% of patients with any early cancer.”  

The Cancer Guide Website Third Opinion refers to Gerson Therapy in the following way: “Especially excellent results are observed in advanced cancers of all types, including: inoperable lymphoma; spreading melanoma; metastasis to the liver; aggressive ovarian cancer; and pancreatic cancer.”  

Advocates of this therapy state it brings no damaging side effects and has been successfully used for over 60 years.  

Max Gerson was a medical doctor from Germany who befriended Nobel Prize winner Albert Schweitzer after curing Schweitzer’s wife of lung tuberculosis when all other treatments had failed. Gerson published many papers on his theories, treatments, and results treating cancer patients naturally. He remains greatly respected in the history of medicine.  

Dr. Gerson died in 1959. The Gerson Institute was established as a non-profit organization in 1978; the Gerson Therapy hospital in Tijuana has been open since 1977. More than 8,000 patients have been treated. Although most arrive in terminal condition, yet many have recovered. Dr. Gerson’s daughter continues her father’s work by consulting at the Gerson Institute. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

  • A Cancer Therapy: Results of Fifty Cases and the Cure of Advanced Cancer by Dr. Max Gerson  
  • The Gerson Therapy: The Proven Nutritional Program for Cancer and Other Illnesses by Charlotte Gerson, et al.  
  • Dr. Max Gerson – Healing the Hopeless by Howard Straus  
  • Healing Cancer and Other Degenerative Diseases With the Gerson Therapy : The Complete Guide to Home Use by Charlotte Gerson  
  • Gerson Diet Therapy for Women’s Cancers: Breast Cancer, Ovarian Cancer, Cervical Cancer by Charlotte Gerson  
  • Gerson Institute/Cancer Curing Society:  
  • CHIPSA: The ‘Official’ Gerson Hospital:  
  • Cassileth BR. Alternative medicine handbook: the complete reference guide to alternative and complementary therapies. New York: W. W. Norton & Co., 1998:186-188.  
  • Diamond WJ, et al. An Alternative Medicine Definitive Guide to Cancer. Tiburon, California: Future Medicine Publishing, Inc., 1997:772.  
  • Weitzman S. Alternative nutritional cancer therapies. Int J Cancer 1998;11(Suppl):69-72.  
  • Third Opinion: An International Resource Guide to Alternative Therapy Centers for Treating and Preventing Cancer, Arthritis, Diabetes, HIV/AIDS, MS, CFS, and Other Diseases by John M. Fink,  
What is 3 Bromopyruvate (3-BP)?

3-Bromopyruvate is a fast acting, promising, powerful, specific, and effective “small molecule” anti-cancer agent taken from labside to bedside. 


Although the “Warburg effect”, i.e., elevated glucose metabolism to lactic acid (glycolysis) even in the presence of oxygen, has been recognized as the most common biochemical phenotype of cancer for over 80 years, its biochemical and genetic basis remained unknown for over 50 years. Work focused on elucidating the underlying mechanism(s) of the “Warburg effect” commenced in the author’s laboratory in 1969.  

By 1985 among the novel findings made two related most directly to the basis of the “Warburg effect”, the first that the mitochondrial content of tumors exhibiting this phenotype is markedly decreased relative to the tissue of origin, and the second that such mitochondria have markedly elevated amounts of the enzyme hexokinase-2 (HK2) bound to their outer membrane. HK2 is the first of a number of enzymes in cancer cells involved in metabolizing the sugar glucose to lactic acid.  

At its mitochondrial location HK2 binds at/near the protein VDAC (voltage dependent anion channel), escapes inhibition by its product glucose-6-phosphate, and gains access to mitochondrial produced ATP. As shown by others, it also helps immortalize cancer cells, i.e., prevents cell death. Based on these studies, the author’s laboratory commenced experiments to elucidate the gene basis for the overexpression of HK2 in cancer.  

These studies led to both the discovery of a unique HK2 promoter region markedly activated by both hypoxic conditions and moderately activated by several metabolites (e.g., glucose), Also discovered was the promoter’s regulation by epigenetic events (i.e., methylation, demethylation).  

Finally, the author’s laboratory turned to the most important objective. Could they selectively and completely destroy cancerous tumors in animals? This led to the discovery in an experiment conceived, designed, and conducted by Young Ko that the small molecule 3-bromopyruvate (3BP), the subject of this mini-review series, is an incredibly powerful and swift acting anticancer agent.  

Significantly, in subsequent experiments with rodents (19 animals with advanced cancer) Ko led a project in which 3BP was shown in a short treatment period to eradicate all (100%). Ko’s and co-author’s findings once published attracted global attention leading world-wide to many other studies and publications related to 3BP and its potent anti-cancer effect.  

This Issue of the Journal of Bioenergetics and Biomembranes (JOBB 44-1) captures only a sampling of research conducted to date on 3BP as an anticancer agent, and includes also a Case Report on the first human patient known to the author to be treated with specially formulated 3BP.  

Suffice it to say in this bottom line, “3BP, a small molecule, results in a remarkable therapeutic effect when it comes to treating cancers exhibiting a “Warburg effect”. This includes most cancer types. SOURCE: PubMed.Gov – November 2012 

About MGN-3 Immune System Enhancement Treatment

MGN3 or MGN-3 used to be a major treatment for cancer. However, due to FDA restrictions the name of this product has been changed more than once.  The most recent reports have stated that the current name for MGN3 is “Daiwa’s PeakImmune4 RBAC.” You may need to use Google to find a current vendor, but we have provided some possible links at the end of this article. 

How It Works 

MGN-3 has been clinically shown to increase Tumor Necrosis Factor (TNF – a cytokine involved in activating the immune system), and increase the number of critical white blood cells: NK-Cells, T-Cells and B-Cells. In other words, MGN-3 works by building the immune system. 


There are a considerable number of impressive testimonials for MGN-3 on the internet, particularly regarding liver cancer and other difficult cancers. 

“This potent immune system booster is manufactured using a patented process which hydrolyzes rice bran with the enzymatic extract from three different medicinal mushrooms: Shiitake, Kawaratake and Suehirotake. In Japan, these mushroom extracts have become the leading prescription treatments for cancer. MGN-3 Contains Arabinoxylane compound – The only natural immune complex that is clinically proven to triple natural killer (NK) cell protection, significantly enhances B-cell & T-cell activity and is supported by 7 published efficacy studies (72 human patients).” 

Supercharging This Treatment 

This substance is usually taken as part of a multi-faceted treatment plan because it is designed to build the immune system. 

Clinical Summary by Memorial Sloan Kettering Cancer Center 

MGN-3 is a proprietary product derived from rice bran. Promoters of MGN-3 claim that it improves immune function against cancer and AIDS. Polysaccharides are the primary ingredients and are thought to increase the levels of TNF-alpha and IFN-gamma secretion, and augment natural killer (NK) cell function in vitro. In vitro and studies in mice have shown that MGN-3 facilitates apoptosis of human T cell leukemia cells, sensitizes human breast cancer cells to a chemo drug, and protects against cisplatin-induced weight loss.
Improved immunomodulatory function was observed with use of MGN-3 in a small study of cancer patients. In another study on patients with liver cancer, MGN-3 increased overall response and reduced adverse effects of standard therapies.  Further research is warranted. MGN-3 did not improve symptoms of chronic fatigue syndrome. No adverse effects have been reported following consumption of MGN-3. 

Purported Uses 

  • Cancer treatment 
  • Chemotherapy side effects 
  • HIV and AIDS 
  • Immunostimulation 

Main ingredients 

  • Rice bran, enzymatically treated with extracts from shiitake (Lentinus edodes), kawaratake (Coriolus versicolor), and suehirotake (Schizophyllum commune) mushrooms

Other ingredients 

  • Beet root fiber 
  • Calcium phosphate 
  • Silica 
  • Magnesium stearate 

Mechanism of Action 

MGN-3 is an arabinoxylan from rice bran made using enzymes from mycelia of shiitake, kawaratake and suehirotake mushrooms. MGN-3 is claimed to cause an overall increase of the immune system, such as natural killer cell activity, increase gamma interferon and tumor necrosis factor-alpha, and to act synergistically with interleukin-2, which also increases natural killer cell activity (2). 

Adverse Reactions 

None reported 

Herb-Drug Interactions 

None reported 

Herb Lab Interactions 

MGN-3 reduces alpha-fetoprotein (AFP) levels in hepatocellular carcinoma patients going through standard therapies (1). 

Literature Summary and Critique 

(1) Ghoneum M. Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, and its synergy with interleukin-2 in vitro. Cancer Detect Prev 2000;24:314.
The mechanism by which MGN-3 elevates NK cytotoxic activity was examined. The effect of MGN-3 on the levels of tumor necrosis factor-alpha and interferon-gamma secretions was measured, as was the expression of key cell surface receptors. Results suggest that MGN-3 is a potent TNF-alpha inducer. Treating highly purified NK cells with MGN-3 also resulted in increased levels of TNF-alpha and IFN-gamma secretion in conjunction with augmentation of NK cell cytotoxic function. Furthermore, addition of MGN-3 to interleukin 2-activated NK cells resulted in a synergistic induction of TNF-alpha and IFN-gamma secretion. 

As of this writing the product is available under the name “PeakImmune4” manufactured by Daiwa through the vendor     

SOURCE:  Webster Kehr – Independent Cancer Research Foundation, Inc. – October 16, 2013 

Alternative Medicine

Complementary and Alternative Medicine (CAM) is the term for medical products and practices that are not part of standard medical care.  

  • Standard medical care is medicine that is practiced by health professionals who hold an M.D. (medical doctor) or D.O. (doctor of osteopathy) degree. It is also practiced by other health professionals, such as physical therapists, physician assistants, psychologists, and registered nurses. Standard medicine may also be called biomedicine or allopathic, Western, mainstream, orthodox, or regular medicine. Some standard medical care practitioners are also practitioners of CAM. 
  • Complementary medicine is treatments that are used along with standard medical treatments but are not considered to be standard treatments. One example is using acupuncture to help lessen some side effects of cancer treatment. 
  • Alternative medicine is treatments that are used instead of standard medical treatments. One example is using a special diet to treat cancer instead of anticancer drugs that are prescribed by an oncologist. 
  • Integrative medicine is a total approach to medical care that combines standard medicine with the CAM practices that have shown to be safe and effective. They treat the patient’s mind, body, and spirit.  

NCI provides evidence-based PDQ information for many CAM therapies in versions for both the patient and health professional. 

Are CAM approaches safe? 

Some CAM therapies have undergone careful evaluation and have found to be safe and effective. However there are others that have been found to be ineffective or possibly harmful. Less is known about many CAM therapies, and research has been slower for a number of reasons: 

  • Time and funding issues 
  • Problems finding institutions and cancer researchers to work with on the studies 
  • Regulatory issues 

CAM therapies need to be evaluated with the same long and careful research process used to evaluate standard treatments. Standard cancer treatments have generally been studied for safety and effectiveness through an intense scientific process that includes clinical trials with large numbers of patients. 

Natural Does Not Mean Safe 

CAM therapies include a wide variety of botanicals and nutritional products, such as dietary supplements, herbal supplements, and vitamins. Many of these “natural” products are considered to be safe because they are present in, or produced by, nature. However, that is not true in all cases. In addition, some may affect how well other medicines work in your body. For example, the herb St. John’s wort, which some people use for depression, may cause certain anticancer drugs not to work as well as they should. 

Herbal supplements may be harmful when taken by themselves, with other substances, or in large doses. For example, some studies have shown that kava kava, an herb that has been used to help with stress and anxiety, may cause liver damage. 

Vitamins can also have unwanted effects in your body. For example, some studies show that high doses of vitamins, even vitamin C, may affect how chemotherapy and radiation work. Too much of any vitamin is not safe, even in a healthy person. 

Tell your doctor if you’re taking any dietary supplements, no matter how safe you think they are. This is very important. Even though there may be ads or claims that something has been used for years, they do not prove that it’s safe or effective. 

Supplements do not have to be approved by the federal government before being sold to the public. Also, a prescription is not needed to buy them. Therefore, it’s up to consumers to decide what is best for them.  

NCI and the National Center for Complementary and Integrative Health (NCCIH) are currently sponsoring or cosponsoring various clinical trials that test CAM treatments and therapies in people. Some study the effects of complementary approaches used in addition to conventional treatments, and some compare alternative therapies with conventional treatments. 

To find current clinical trials for CAM therapies go to or to  

Dr. Jeffrey D. White, OCCAM Director, explains the use of complementary and alternative medicine in cancer. 

What Should Patients Do When Using or Considering CAM Therapies? 

Cancer patients who are using or considering using complementary or alternative therapy should talk with their doctor or nurse. Some therapies may interfere with standard treatment or even be harmful. It is also a good idea to learn whether the therapy has been proven to do what it claims to do. 

To find a CAM practitioner, ask your doctor or nurse to suggest someone. Or ask if someone at your cancer center, such as a social worker or physical therapist can help you. Choosing a CAM practitioner should be done with as much care as choosing a primary care provider. 

Patients, their families, and their health care providers can learn about CAM therapies and practitioners from the following government agencies: SOURCE: National Cancer Institute – April 29, 2015 


About Systemic Proteolytic Enzymes

To help cleanse your kidneys is only one of many reasons to use systemic proteolytic enzymes. These medical wonders can be used as a safe alternative treatment or as an adjunct to standard medical treatment for many chronic illnesses and inflammatory conditions. 

Different Kinds Of Enzymes 

Systemic enzyme therapy with proteolytic enzymes is quite different from digestive enzymes (which are used to help digestion in the digestive tract). These systemic enzymes are proteases that you can take on an empty stomach so they can freely enter the bloodstream. Once there, they dismantle problem proteins that are involved in your immune system’s inflammation process. In this way they have many medical uses, which I’ll discuss in a moment. 

Systemic proteolytic enzyme studies are found throughout the peer-reviewed scientific literature. They have also been quite extensively studied in Germany by the company that manufactures Wobenzym® N and Wobenzym® PS. There are many companies now manufacturing these substances from animals (trypsin, chymotrypsin), plants (bromelain, papain), bacteria (serrapeptidase) and fungi (Serrazimes®). 

Enzymatic Action 

In general, proteolytic enzymes have been found to clear the harmful immune complexes that form as a result of antibody reactions. Therefore, they are anti-inflammatory. 

They are known to: 

  • Regulate cytokine activity and help clear inflammatory cytokines. [1] Cytokines are proteins made by a wide variety of cells whose signals set off inflammation, such as tumor necrosis factor-alpha (TNF-α) and the interleukins. 
  • Enhance the clearance of damaged proteins, remove fibrin and their fragments found in the blood during inflammation, improve blood circulation and decrease clots. [2] 
  • Reduce advance glycation end-products (AGEs) [3] and their receptors on cells. These AGEs are a form of inflammation (intracellular damage and apoptosis, or programmed cell death) implicated in age-related diseases such as Alzheimer’s disease, [4] cardiovascular disease, [5] stroke, [6] reduced muscle function and more. 
  • Down-regulate adhesion molecule activity of inflamed cells and cancer cells. 
  • Clean dead material from the blood [7] so it can be filtered through the liver and kidneys. 
  • Improve white blood cell availability and function to fight off infection. [8] 

Improving Chronic Conditions  

Systemic proteolytic enzymes have been shown to digest the protective protein coating of pathogens [9] (such as bacteria, viruses, parasites, fungi and candida) to make them inert, [10] [11] and they have a similar effect against cancer cells. [12] Because systemic enzymes safely and effectively clean the bloodstream, they reduce the toxic load to the kidneys. They should be used the week prior to and during a kidney cleanse as described in my article that appeared last week. 

Research demonstrates that there are other conditions for which systemic proteolyic enzymes are useful: 

Alzheimer’s disease: Reduces amyloid beta peptide in the brains of these patients. [13] 

Arthritis: A safe and effective NSAIDs alternative for the pain of knee and hip osteoarthritis. [14] In rheumatoid arthritis proteolytic enzymes can protect and preserve joint cartilage even better than NSAIDs. [15] Systemic proteolytic enzymes improve every form of arthritis and can be safely added to standard medical therapy. 

Asthma: Reduces dyspnea attacks (shortness of breath) and respiratory infections in children with asthma. [16] 

Cardiovascular disease: Reduces angina attacks and improves tolerance of physical workload in patient with stable angina. [17] Proteolytic enzyme therapy also showed a reduction of repeated heart attack in patients with known heart disease. [18] 

Infertility: Improves autoimmune and alloimmune (reaction to your partner) infertility. 

Lymphedema: Can effectively resolve lymphedema in upper and lower extremities because it removes fibrin and improves lymphatic flow. [19] 

Multiple sclerosis (MS): Decreases the frequency and length of attacks. [20] 

Psoriasis and eczema: Recurrence was decreased and symptoms reduced. [21] When proteolytic enzyme therapy was added to standard psoriasis medical treatment, it rapidly improved eczema. [22] 

Strains and sprains: Reduced duration of injury in top athletes and enhanced recovery from sprains. [23] 

Thrombophlebitis: Acute thrombophlebitis as well as post-thrombophlebitic syndrome were greatly improved; subjects had decreased pain, reduced edema and fewer trophic ulcers. [24] 

Thyroid disease: Autoimmune thyroiditis was significantly decreased; L-thyroxine dosages were able to be lowered. [25] 

Urinary infections/stones: Recurring urinary tract infections [26] and kidney stones [27] were fewer. Also, systemic proteolytic enzymes improved the lab results in patients with pyelonephritis better than standard medical treatment. [28] 

Some Things To Know About Proteolytic Enzymes 

Proteolytic enzymes are measured in fibrinolytic units (how quickly they break down fibrin). They start working as soon as they are absorbed. Contraindications include any other special risk for bleeding (blood thinners, post-surgery, pregnancy complications); taking antibiotics (interferes with their mechanism of action); or allergy to papayas or pineapples (the enzymes may have been formulated from these sources). 

If you take proteolytic enzymes, you may need to supplement with magnesium (500-1,000 mg) and zinc (30 mg) to help them activate optimally. 

Next week, I’ll discuss how these enzymes have been used in cancer treatments (Kelly-Gonzales protocol) and how they are used in cancer treatment currently. 

To feeling good for life, 
Michael Cutler, M.D. 
Easy Health Options 

Designer Nanoparticles Infiltrate and Kill Cancer Cells from Within

Nanoparticle designs target and treat early stage cancer cells by killing those cells with heat, delivered from inside the cell itself. Normal cells are thus left unaffected by the treatment regimen. 

UC nanoparticle designs target and treat early stage cancer cells by killing those cells with heat, delivered from inside the cell itself. Normal cells are thus left unaffected by the treatment regimen.  

Conventional treatment seeks to eradicate cancer cells by drugs and therapy delivered from outside the cell, which may also affect (and potentially harm) nearby normal cells. 

In contrast to conventional cancer therapy, a University of Cincinnati team has developed several novel designs for iron-oxide based nanoparticles that detect, diagnose and destroy cancer cells using photo-thermal therapy (PTT). PTT uses the nanoparticles to focus light-induced heat energy only within the tumor, harming no adjacent normal cells. 

The results of the UC work will be presented at the Materials Research Society Conference in Boston Nov. 30-Dec. 5 by Andrew Dunn, doctoral student in materials science engineering in UC’s College of Engineering and Applied Science. Working with Dunn in this study are Donglu Shi, professor of materials science engineering in UC’s College of Engineering and Applied Science; David Mast, associate professor of physics in UC’s McMicken College of Arts and Sciences; and Giovanni Pauletti, associate professor in the James L. Winkle College of Pharmacy. 

The UC study used the living cells of mice to successfully test the efficacy of their two-sided nanoparticle designs (one side for cell targeting and the other for treatment delivery) in combination with the PTT. However, the U.S. Food and Drug Administration has now approved the use of iron-oxide nanoparticles in humans. That means the photo-thermal effect of iron-oxide nanoparticles may show, in the next decade, a strong promise in human cancer therapy, likely with localized tumors. 

How the Nanoparticles Work With Photothermal Therapy 

With this technology, a low-power laser beam is directed at the tumor where a small amount of magnetic iron-oxide nanoparticles are present, either by injecting the particles directly into the tumor or injecting them into the blood stream whereby the particles find and bind to the abnormal cancer cells via cell-specific targeting. 

Sufficient heat is then generated locally by the laser light, raising the tumor temperature rapidly to above 43 degrees Celsius, and thereby burning the abnormal cancer cells. This particular PTT treatment does not involve any medicine, but only generates local heat within the tumor, therefore posing much less side effects than the traditional chemo or radiation therapies. 

“This treatment is much more ideal because it goes straight to the cancer cell,” says Shi. “The nanomaterials enter only the abnormal cells, illuminating those cells and then doing whatever it is you have designed them to do. In this case, it is to heat up hot enough to burn and kill the cancer cells, but not harm the surrounding normal cells.” 

Shi added that physicians are often frustrated with the current conventional means for early imaging of cancer cells through Medical Resonance Imaging or Computerized Tomography scans because the tumors are usually stage three or four before they can be detected. He stated, “With nanomaterial technology, we can detect the tumor early and kill it on sight at the same time.” 


Cell Targeting 

  • Each tumor has a corresponding protein that is cancer specific called a tumor specific ligand or an antibody antigen reaction that only has expression for that specific cancer such as breast or prostate cancer. 
  • Scientists identify this certain bio-marker that is specific to a certain tumor, then conjugates this bio-marker on the surface of the nanocarrier that only has the expression for that specific kind of cancer cell. 
  • It then only targets the abnormal cancer cell, not normal, healthy cells, and because it is so small it can break the membrane and enter that conjugated cancer cell and release the PTT. 
  • The nanotech carriers go into the body through a vein in the blood stream, seek the abnormal cancer cells, find the bio-marker or cancer cells and attach to those cells and unlock their florescent particles so they can be detected by a photon laser-light. 
  • The laser-light heats the nanoparticles to at least 43 degrees Celsius to kill the cancer cells, ultimately leaving all the other cells in the body unharmed. 

Potential DIY Cancer Treatment 

The procedure can ultimately be carried out by the patient themselves after being trained how to direct a small laser light device to the affected area for a specified amount of time two to three times a day. This method can ultimately improve the success rate, as well as cut costs to the patient. This gives “point and shoot” a whole new meaning. 

Future Research 

Future research in nanoparticle PTT will look at toxicity, biodegradability and compatibility issues. Shi said that the team is currently looking for other diverse biodegradable materials to use for the carriers such as plant chlorophylls like those in cabbage that are both edible and photothermal. This material is biocompatible and biodegradable and can potentially stay in the tumor cells until its job is finished, then dissolve and be passed out through the digestive system. 

Support for this research was provided by a National Science Foundation grant under contract number MSF (1343568) titled “Development of Nanotechnology Minor Focused on Nano Biomedicine and Sustainable Energy.” SOURCE: Science Daily – University of Cincinnati – November 24, 2014 

Magnolia Bark for Head and Neck Cancers

Magnolia bark is a popular medicinal remedy in traditional Chinese and Japanese medicine. It’s been used to treat: 

  • Asthma 
  • Coughs 
  • Anxiety 
  • Menstrual cramps 
  • Stomach troubles 
  • Nausea 
  • Gas 
  • Indigestion 

Modern medicine is showing magnolia bark for head and neck cancers may be a viable cancer treatment, and a new study out of University of Alabama at Birmingham reveals it may be particularly effective at treating and preventing head and neck cancers. 

Honokiol to the Rescue 

According to the National Cancer Institute, 3 out of 4 head and neck cancers are caused by alcohol and tobacco use. With only a 50% survival rate, head and neck cancers claim the lives of approximately 20,000 Americans annually. Thus far, cancer treatment drugs have shown only limited effectiveness at treating these types of cancers, but a compound in magnolia bark may provide a less toxic and more natural cancer treatment alternative. 

Honokiol is 1 of 5 primary active compounds in magnolia bark. Along with magnolol, another of magnolia bark’s compounds, honokiol is reported to have up to 1000 times the potency of vitamin E. University of Alabama researchers showed that it works against head and neck cancers—such as oral cavity, larynx, tongue, and pharynx cancers—by suppressing a protein called epidermal growth factor receptor (EGFR). 

Research has shown that most head and neck cancer cells have extremely elevated levels of EGFR. By binding to these cells even more effectively than commonly used cancer treatment drugs such as gefitinib (sold as Iressa), honokiol squelches cancer cells. Researchers also tested honokiol on tumors implanted into mice, and the magnolia bark compound was likewise effective. 

Senior author Dr. Santosh K. Katiyar and his colleagues report, “Conclusively, honokiol appears to be an attractive bioactive small molecule phytochemical for the management of head and neck cancer which can be used either alone or in combination with other available therapeutic drugs.” 

Put magnolia bark’s potency to work for you by adding magnolia bark extract or magnolia tea to your daily alternative healthcare prescription. Read more: 

A Promising New Cancer Therapy That's Under Attack

In 2008-2009, four human studies appeared claiming fantastic results for a groundbreaking new cancer treatment. The studies were conducted Dr. Nabuto Yamamoto, who at the time was a Professor of Biochemistry at Temple University Medical School in Philadelphia. He was assisted by a team of other researchers. 

If the results hold up, the new treatment – a natural enzyme found in a healthy human body — could be one of the most exciting new cancer developments ever seen.  

In the first study, Dr. Yamamoto supplied the enzyme to doctors treating HIV patients — resulting in complete eradication of the infection. After seven years follow-up, their blood counts remained normal.  

In another study, the Yamamoto team treated 16 nonanemic metastatic breast cancer patients with a single injection of 100 nanograms of GcMAF per week for 22 weeks. The treatment resulted in tumor eradication. Patients were well after four years follow-up. 

In the third study, all 16 nonanemic metastatic prostate patients were tumor-free after 24 weeks and remained so at seven years follow-up. 

In the fourth study, all eight nonanemic metastatic colorectal patients were cancer-free after 48 weeks and remained so at seven years follow-up as confirmed by CT scans. 

In short – and astonishing as it sounds — Professor Yamamoto achieved a 100% remission rate in metastatic cancer patients.  

The discovery didn’t happen overnight. It was the product of years of research at a respected mainstream medical institution.  

The pioneering work of Dr Yamamoto 

The foundations of GcMAF began in 1979 when Dr. Yamamoto started basic research in molecular biology and immunology. Each insight obtained in one study became the driving force for the design of the next. 

These building blocks of knowledge grew until they formed a huge infrastructure that became his basis for a new theory about how cancer occurs and how it could be treated.  

The first publication in a peer-reviewed journal on GcMAF appeared in 1994. Dr. Yamamoto and colleagues at Temple University demonstrated that GcMAF activated macrophages. These are vital immune cells that kill pathogens and cancer cells and switch on other aspects of the immune system.  

A year later he showed that a defect in the production of GcMAF inside the body contributes to a poorer immune response in AIDS patients. In 1996 he demonstrated that this was also the case in cancer patients.  

What is GcMAF and how does it work? 

Professor Yamamoto discovered that cancer cells and some viruses, but not normal cells, secrete an enzyme called alpha-N-acetyl- 
galactosaminidase (Nagalase).  

This enzyme is able to block the production of a protein that activates macrophages to attack the cancer cells. He named this Gc-protein-derived Macrophage Activating Factor — GcMAF for short 

Certain immune cells – T and B lymphocytes – make GcMAF from its precursor, vitamin D-binding protein (Gc protein). This protein has three sugars attached to the 420th amino acid along its 458 amino acid chain. The removal of two of these sugars by enzymes produced by the lymphocytes turns Gc protein into GcMAF 

The enzyme released by cancer cells and some viruses, nagalase, removes all the sugars from Gc protein, thereby preventing its conversion to GcMAF — and rendering the patient’s immune system deficient. The sugar-removing process is called deglycosylation 

Cancer’s ability to block macrophages by nagalase can be bypassed by injecting GcMAF. The treatment restores normal immunity and the body is then able to attack tumor cells.  

Professor Yamamoto demonstrated that when macrophages are activated by GcMAF their activity increases by 30-fold. There is also a 15-fold rise in superoxide ions. These also attack pathogens and cancer cells.  

The remarkable results he obtained in human studies were owing to the fact that he was very careful about which patients to include.  

GcMAF is least likely to work in patients who have a large tumor burden and in those whose tumors are well differentiated (i.e. look similar to normal cells). It works best in those with a low tumor load and in poorly differentiated (highly abnormal) cells. 

GcMAF can be stopped from working by opiates, patients lacking sufficient red blood cells, or those with low white blood cell counts.  

Dr. Yamamoto’s subjects had undergone conventional therapies to reduce the tumor burden to a very low level. They were also at an early stage of metastasis and had no conditions that could block the protein.  

Other anticancer effects of GcMAF 

Until 2002 it was believed GcMAF activated only macrophages. Then Professor Yamamoto, together with researchers from Japan, discovered that “GcMAF has direct anti-angiogenic effects on endothelial cells.” (Angiogenesis is the process whereby cancer tumors form their own network of blood vessels.)  

This finding was confirmed the following year by the highly distinguished doctor Judah Folkman and others at Children’s Hospital in Boston.  

For one factor to both activate the immune system and anti-angiogenesis is remarkable, but the good news doesn’t stop there.  

In 2010, researchers from the University of Kentucky showed for the first time that GcMAF directly inhibits the migration, proliferation and metastatic potential of human prostate cancer cells. This happened independently of macrophage activation.  

And in 2012 the Kentucky discovery was confirmed in breast cancer cells, thanks to the efforts of Marco Ruggiero, a professor of molecular biology, working with a team at the University of Florence, Italy.  

But what was more extraordinary, the Italian researchers demonstrated a reversal of breast cancer cells to their neoplastic phenotype. In other words, GcMAF reverted cancer cells back to normal cells.  

They also published a study in 2011 demonstrating that GcMAF can counter the potentially carcinogenic effects of cadmium in human breast cancer cells.  

GcMAF takes a leap forward 

Professor Ruggiero and his wife Dr. Pacini realized that the enzymes that act on Gc protein to turn it into GcMAF also occur during the fermentation of milk.  

They therefore set about creating a super-yogurt called MAF314. This contains over 30 microorganisms and strains of bacteria in highly defined proportions to create a potent immune-enhancing food product that, they say, can also restore a healthy human microbiome (the 3½ pounds of “friendly” bacteria that reside in the gut).  

Professor Ruggiero then experienced a eureka moment. He realized that GcMAF needs to combine with oleic acid to function. He said, “This neglected association between oleic acid and GcMAF was the missing link that more than a thousand researchers including Dr. Yamamoto and myself had been seeking for the past 20 years.”  

Prof. Ruggiero and Dr. Pacini then went on to combine GcMAF with oleic acid to create GOleic 

Unlike GcMAF, which has to be injected, or MAF314, which can be either eaten or administered into the colon, GOleic, in addition to these methods of administration, can be taken as sublingual drops, a spray, suppositories or even as an ointment.  

Prof. Ruggiero claims to have demonstrated that GOleic is far more potent than GcMAF and has effects at a molecular level that cannot be reproduced with the protein alone.  

Professor Ruggiero leaves Italy 

Like Dr. Yamamoto, Prof. Ruggiero had also researched HIV. He rejects the accepted theory and co-authored a paper in 2009 on an alternative approach. This was met with both great approval and denigration (the paper was later permanently withdrawn). 

Not going along with the medical establishment has its price. After continued attacks on his integrity, defamatory statements made about him, and a raid on his home, Prof. Ruggiero and his wife left Italy for Switzerland. Here they met David Noakes 

Computer consultant, anti-European Union campaigner and entrepreneur, Mr. Noakes manufactured GcMAF and GOleic and made them commercially available. The therapy was offered in Swiss and German clinics. International conferences on GcMAF took place. Research facilities and funding for Professor Ruggiero were provided.  

The Swiss Protocol 

Prof. Ruggiero developed a more comprehensive approach to treating cancer, which is called the Swiss Protocol. It involves. . . 

  • A high protein, low carbohydrate diet (can be as low as 2% depending on the type of tumor). As readers of this newsletter know, I strongly advocate a low-carbohydrate diet for all, and especially for cancer patients. 
  • High absorption and rapidly utilized amino acids in the form of Master Amino Acid Pattern (MAP) proteins 
  • MAF314 taken either by mouth or into the colon depending on the type of cancer 
  • GOleic. The practitioner may inject this substance at the site of the tumor or administer it in other ways. 
  • Vitamin D. Up to 20,000 IU a day may be recommended. Note that this is far more than even alternative doctors recommend, and is in line with what I’ve suggested previously in this newsletter. Blood tests are the only way to determine how much vitamin D a patient needs, and the amount is nearly always far more than the four or five thousand daily IUs that even “aggressive” alternative doctors recommend. 
  • Water. Two liters a day may be suggested. 
  • Low dose acetylsalicylic acid may be prescribed 

Examples of the Ruggiero team’s work in patients using the new protocol were presented at the 9th International Conference of Anticancer Research in Greece in October, 2014.  

In the first case study, the total elimination of an important oncogene (HER-2) in a breast cancer patient was described for the first time.  

Two other successful cases were presented involving patients with metastatic pancreatic cancer. Pancreatic cancer is generally considered a death sentence by conventional oncologists. 

In a third instance, revealed for the first time was a successful method for treating incurable brain tumors using transcranial ultrasonography to allow permeability of the blood brain barrier and targeted delivery of GOleic 

Used widely around the world 

During the last 25 years a large number of scientists in eight countries have published research on GcMAF, and thanks to David Noakes it has now been supplied to 350 doctors in 30 nations. Professor Ruggiero estimates that over 200 doctors worldwide are following his protocols.  

Unfortunately, Mr. Noakes let his enthusiasm run away with him and made some outrageous public statements such as:  

“We always cure prostate cancer, it’s a piece of cake….We always cure lung and breast cancer which are very easy.”  

We can’t be sure, but Mr. Noakes’s over-the-top remarks may have led to a regulatory crackdown that started a few months later. . .  

Government tries to put a stop to GcMAF treatment  

In February, 2015, ten investigators burst into Immuno Biotech’s lab unannounced, and terrified two female scientists before removing 10,000 vials of GcMAF, a chemical that occurs naturally in milk and blood. Immuno Biotech is apparently owned or controlled by Mr. Noakes 

Surprisingly, this didn’t take place in the USA – where such raids on doctors and promoters of nontoxic therapies for cancer are almost expected – but in a quiet village in rural England.  

The Medicine and Healthcare Products Regulatory Agency (MHRA) – the UK equivalent of the FDA – claimed the product “may pose a significant risk to people’s health.”  

Mr. Noakes didn’t pull any punches: “The MHRA does not want to see this product on the market because its job is to maintain the monopoly and stick up for vested interests in the pharmaceutical industry.”  

Besides the regulatory crackdown, a BBC television news magazine show lambasted him and GcMAF 

There’s more: Other scientists have attacked both the Yamamoto and Ruggiero research and claim to have identified irregularities in the way some of the studies were conducted, reviewed and published. At least one Yamamoto study, published in the International Journal of Cancer, has been retracted by the publication’s editor.  

I am not in a position to evaluate the merits of the professional attacks; I do believe more corroboration is needed to confirm the claims that have been made, before we can be sure GcMAF is all that Drs. Yamamoto and Ruggiero have said.  

As often is the case with alternative treatments, GcMAF is harmless and can be used in conjunction with chemotherapy AND with other alternative therapies. In fact, as noted above, Dr. Yamamoto seems to require that patients reduce the size of their tumors by conventional means before he considers them candidates for GcMAG 

You can get it if you really want. . . 

Regardless of Mr. Noakes’s unwise remarks, there is no doubt that this is a promising new treatment. Just bear in mind that it’s been used in human patients only since 2008 and there isn’t much clinical evidence to support it.  

The IAT Clinic in the Bahamas is impressed enough to include GcMAF as part of its cancer protocols, as does the Rosenberg Integrative Cancer Treatment and Research Institute in Florida. Other clinics in Nevada, Arizona, and California also prescribe it, as well as health centers in Japan.  

Andrew Scholberg, the author of our book America’s Best Cancer Doctors, plans an investigative trip to the IAT Clinic in the next few months, and hopefully he’ll learn good things about GcMAF and other treatments as well. 

As I write this, I don’t know whether David Noakes has found new production facilities outside the UK, where the treatment is now against the law. The original European clinics appear to have closed, but there are now two in the Netherlands; their exact location is not disclosed.  

Let’s hope this exciting treatment turns out to be everything its adherents claim, and that the regulators don’t succeed in quashing it as they have so many therapies in the past. 

Meanwhile there’s another exciting cancer therapy you can buy at any health food store. It was in the last issue. If you missed it, you can read it now just below this. SOURCE: Cancer Defeated – August 2, 2015 



A New Cancer Treatment Has Given Terminal Patients a Second Chance at Life

Despite the many advances in medicine over the last century, a cure for one of the most prevalent and devastating diseases in the world today continues to evade us. But thanks to new research, that could soon change. 

Could This Treatment Cure Cancer? 

Kite Pharma, a US pharmaceutical company, just released the groundbreaking results of their six-month gene therapy trial: terminal cancer patients in complete remission after just a single round. 

  • Gene therapy has been shown in clinical trials to not just treat cancer, but possibly cure it.  
  • The treatments have risks — including death — so additional research is needed before they could become widely available.  

The treatment filters a patient’s blood to remove T-cells, immune system cells that can be genetically engineered in a lab to identify cancer cells. Cancer cells thrive because of their ability to evade the immune system. This new therapy boosts immune cells so that they are able to eliminate cancer cells more effectively. 

Patients who participated in the trial had one of three types of non-Hodgkin lymphoma. The advanced stage of their conditions meant all of them were given only a few months to live. However, following the first round of gene therapy, which took place nine months after the trial began, half the patients are not only still alive, but a third of them appear to be cured. 

Among them is a 43- year-old named Dimas Padilla from Orlando, Florida whose cancer had stopped responding to chemotherapy. He completed the first round of the trial’s treatment last August, and his cancer is now in remission. 

Worth The Risk? 

“These results are promising and suggest that one day CAR-T cells could become a treatment option for some patients with certain types of lymphoma,” said head cancer information nurse, Martin Ledwick from the Cancer Research UK, in an interview with The Telegraph. 

While the results are promising and could prove to be life- changing for patients with terminal cancer, the treatment is not without risks. 

Because the therapy essentially puts the human immune system to go into overdrive by radically altering human cells, complications are certainly possible — some of which could be fatal. In fact, during the trial, two people died as a result of the therapy — not because of the cancer. Some patient’s immune systems overreacted in its effort to kill the cancer cells, while others developed blood-count related issues such as anemia. Reports of patients suffering from neurological problems were also cited, but these side effects apparently only lasted a few days. 

More studies are needed to understand the therapy’s side effects, potential complications, and long-term benefits. 

The trial’s full results won’t be presented until April, and the pharmaceutical company still has to get approval from the European regulatory boards — which means it will be a while yet before the therapy becomes available. Given the possible risks, it might give them enough time to study the therapy further and refine the process — hopefully eliminating any adverse effects. 

Although, as the Cancer Institute’s Dr. Steven Rosenberg points out: “It’s a safe treatment, certainly a lot safer than having progressive lymphoma.” SOURCE: Futurism – March 3, 2017 

Oncology Nurses Help Patients Navigate Medicinal Marijuana Complexities

 “It’s complicated,” said Lisa Kennedy Sheldon, PhD, APRN-BC, AOCNP, of the Dana-Farber Cancer Institute in Boston and chief clinical officer at ONS. 

“There are a lot of regulations,” she said. “How do you know what’s standardized? How much do you give people? Side effects and symptoms? And all of this conflicts with federal law.” 

The federal government still classifies cannabis as a Schedule I narcotic, meaning that it has no recognized medicinal value and has a high risk of abuse. 

This was not always the case, Sheldon said. In the 1800s, physicians routinely dispensed cannabis to help their patients with pain, menstrual cramps, cough, and dozens of other illnesses and conditions. 

Following resurgent use in the 1960s in the counterculture and among Vietnam war protestors, President Nixon signed the 1970 Controlled Substances Act, which declared marijuana a Schedule I drug, alongside heroin, as part of the new “war on drugs.” 

The US Drug Enforcement Agency has been petitioned five times since 1972 to reschedule marijuana but each request has been denied. California was the first state to legalize medicinal marijuana, in 1996. Today, 25 states have such programs, but their details vary from state to state. Despite such state programs, marijuana remains illegal under federal law, complicating medical research efforts. 

Restrictions on clinicians’ roles and inpatient rules for medicinal marijuana vary from state to state and facility to facility, Sheldon cautioned. 

Cannabis and cannabinoids are beginning to play a larger role in cancer palliation, and it is important for oncology nurses to better understand associated psychopharmacologic, clinical, and safety issues, said Carey S. Clark, PhD, RN, AHN-BC, associate professor of the University of Maine in Augusta and president-elect of the American Cannabis Nurses Association. 

Cannabinoid receptors are found not only in the brain but throughout the body, with roles in bone physiology, inflammation, fat storage, blood pressure regulation, and hormone levels, Clark said. 

“Cannabinoids can help with appetite,” Clark said. “Early palliation is really key for treating our cancer patients. Cannabis can help with pain, nausea, sleeping and depression issues, and anxiety.” 

Different cannabis strains and products have different levels of the cannabinoids tetrahydrocannabinol (THC) and cannabigerol, and can therefore have different effects, Clark cautioned. 

Cannabinoid receptors and the body’s own endocannabinoids are found in pain circuits throughout patients’ bodies, modulating both pain sensitivity (nociception) and inflammation-associated pain. 

There is evidence that cannabis can help prevent opioid dose escalation, Clark said. 

“Cannabis can be used safely with opiates,” she asserted. “There are very few cannabinoid receptors in the brainstem.” 

Oncology nurses should be prepared to inform patients on state laws and how and where patients can safely and legally obtain medicinal marijuana. 

“Even in states with medical marijuana, some doctors are still reluctant to recommend cannabis, but hopefully that will change as we get past the fear and stigma associated with it,” she said. “We need to be part of ending the stigma associated with cannabis use—particularly medicinal use.” 

Nurses also need to be ready to communicate with patients about the different delivery devices and to caution them about dosing, Clark said. 

“I recommend that patients start low and go slow,” she said. “And to be mindful and conscious of the effects they’re having.” 

Patients should be advised to keep a diary to log when they consumed cannabis, how much, its effects and any side effects, as well as possible medical interactions, Clark said. It is often up to nurses to learn how best to support and inform their patients. 

Common side effects include psychomotor and cognitive impairment, fatigue, dizziness, dry mouth, tachycardia, and dry eyes. Vomiting, sometimes attributed to cannabis hyperemesis syndrome, might actually be caused by contaminants rather than cannabis per se. “You want testing for pesticides, heavy metals, and fungi,” she said. 

In part because of the scant clinical research base for marijuana, there are unanswered questions about its safety for patients with cancer, Clark acknowledged. There are suspected THC safety issues for patients with hormone-positive tumors. 

Cannabis also can be associated with increased bleeding time and changes in blood glucose and blood pressure, Clark noted. Importantly, it might also affect cytochrome P450 enzyme activity in the liver, and hence drug pharmacokinetics—a potential drug-interaction concern. And it is important that marijuana be kept away from children and pets. SOURCE: Cancer Network – April 29, 2017 


About Bicarbonate Maple Cancer Treatment

The bicarbonate maple syrup cancer treatment focuses on delivering natural chemotherapy in a way that effectively kills cancer cells but significantly reduces the brutal side effects experienced with most standard chemotherapy treatments. In fact so great is the reduction that the dangers are brought down to zero. Costs, which are a factor for the majority of people, of this particular treatment are nil. Though this cancer treatment is very inexpensive, do not assume it is not effective. The bicarbonate maple syrup cancer treatment is a very significant cancer treatment every cancer patient should be familiar with and it can easily be combined with other safe and effective natural treatments.  

This cancer treatment is similar in principle to Insulin Potentiation Therapy (IPT). IPT treatment consists of giving doses of insulin to a fasting patient sufficient to lower blood sugar into the 50 mg/dl. In a normal person, when you take in sugar the insulin levels go up to meet the need of getting that sugar into the cells. In IPT they are artificially injecting insulin to deplete the blood of all sugar then injecting the lower doses of toxic chemo drugs when the blood sugar is driven down to the lowest possible value. During the low peak, it is said that the receptors are more sensitive and take on medications more rapidly and in higher amounts.  

The bicarbonate maple syrup treatment works in reverse to IPT. Dr. Tullio Simoncini acknowledges that cancer cells gobbles up sugar so when you encourage the intake of sugar it’s like sending in a Trojan horse. The sugar is not going to end up encouraging the further growth of the cancer colonies because the baking soda is going to kill the cells before they have a chance to grow. Instead of artificially manipulating insulin and thus forcefully driving down blood sugar levels to then inject toxic chemo agents we combine the sugar with the bicarbonate and present it to the cancer cells, which at first are going to love the present. But not for long!  

This treatment is a combination of pure, 100% maple syrup and baking soda and was first reported on the Cancer Tutor site. When mixed and heated together, the maple syrup and baking soda bind together. The maple syrup targets cancer cells (which consume 15 times more glucose than normal cells) and the baking soda, which is dragged into the cancer cell by the maple syrup, being very alkaline forces a rapid shift in pH killing the cell. The actual formula is to mix one part baking soda with three parts (pure, 100%) maple syrup in a small saucepan. Stir briskly and heat the mixture for 5 minutes. Take 1 teaspoon daily, is what is suggested by Cancer Tutor but one could probably do this several times a day.  

“There is not a tumor on God’s green earth that cannot be licked with a little baking soda and maple syrup.” That is the astonishing claim of controversial folk healer Jim Kelmun who says that this simple home remedy can stop and reverse the deadly growth of cancers. His loyal patients swear by the man they fondly call Dr. Jim and say he is a miracle worker. “Dr. Jim cured me of lung cancer,” said farmer Ian Roadhouse. “Those other doctors told me that I was a goner and had less then six months to live. But the doc put me on his mixture and in a couple of months the cancer was gone. It did not even show up on the x-rays.”  

Dr. Jim discovered this treatment accidentally somewhere in the middle of the last century when he was treating a family plagued by breast cancer. There were five sisters in the family and four of them had died of breast cancer. He asked the remaining sister if there was anything different in her diet and she told him that she was partial to sipping maple syrup and baking soda. Since then, reported by a newspaper in AshvilleNorth Carolina, Dr. Jim dispensed this remedy to over 200 people diagnosed with terminal cancer and amazingly he claims of that number 185 lived at least 15 more years and nearly half enjoyed a complete remission of their disease. When combined with other safe and effective treatments like transdermal magnesium therapy, iodine, vitamin C, probiotics and other items like plenty of good sun exposure, pure water and clay treatments we should expect even higher remission rates. 


It is very important not to use baking soda which has had aluminum added to it. The Cancer Tutor site reports that Arm and Hammer does have aluminum but the company insists that is not true. One can buy a product which specifically states it does not include aluminum or other chemicals. (e.g. Bob’s Red Mill, Aluminum-Free, Baking Soda). Sodium bicarbonate is safe, extremely inexpensive and unstoppably effective when it comes to cancer tissues. It’s an irresistible chemical, cyanide to cancer cells for it hits the cancer cells with a shock wave of alkalinity, which allows much more oxygen into the cancer cells than they can tolerate. Cancer cells cannot survive in the presence of high levels of oxygen. Studies have already shown how manipulation of tumor pH with sodium bicarbonate enhances some forms of chemotherapy. [iii] 


“The therapeutic treatment of bicarbonate salts can be administered orally, through aerosol, intravenously and through catheter for direct targeting of tumors,” says oncologist Dr. Tullio Simoncini. “Sodium bicarbonate administered orally, via aerosol or intravenously can achieve positive results only in some tumors, while others – such as the serious ones of the brain or the bones – remain unaffected by the treatment.” 


The maple syrup apparently enables and increases penetration of bicarbonate into all compartments of body, even those which are difficult or impossible to penetrate by other means. These compartments include the central nervous system (CNS), through the blood-brain barrier, joints, solid tumors, and perhaps even the eyes. IPT makes cell membranes more permeable, and increases uptake of drugs into cells. The maple syrup will make tissues more permeable, too. It will transport the bicarbonate across the blood-brain barrier and every other barrier in the body for sugar is universally needed by all cells in the body. The essence of IPT is that it allows cancer drugs to be given in a smaller dose, far less toxic to normal cells, while building up lethally toxic concentrations in cancer cells. Both IPT and bicarbonate maple syrup treatments use the rabid growth mechanisms of the cancer cell against them. 


Dr. Jim did not have contact with Dr. Simoncini and did not know that he is the only oncologist in the world who would sustain the combining of sugar with bicarbonate. Dr. Simoncini always directs his patients to dramatically increase sugar intake with his treatments but has never thought to mix the two directly by cooking them together. Because his treatments depend on interventionist radiologists who insert catheters to direct the bicarbonate as close to the affected area as possible, or physicians willing to do expensive intravenous treatments, I pushed bicarbonate up into the number six slot in the IMVA cancer protocol. With the discovery of Dr. Jim’s work bicarbonate comes back into our number three spot right behind magnesium chloride and iodine.  


That number three slot for a brief time was held by hemp oil containing THC. The great advantage that maple syrup and bicarbonate treatment has over this type hemp oil is that it is legal thus easily obtainable. The two together, backed by a solid protocol of other nutritional substances makes winning the war on cancer almost a certainty. When using these substances it is safer to change one’s vocabulary and not say one is treating and curing cancer. Far better to conceptualize that one is treating the infectious aspect of cancer, the fungus and yeast colonies and the yeast like bacteria that are the cause of TB. 


Dr. Simoncini says that, “In some cases, the aggressive power of fungi is so great as to allow it, with only a cellular ring made up of three units, to tighten in its grip, capture and kill its prey in a short time notwithstanding the prey’s desperate struggling. Fungus, which is the most powerful and the most organized micro-organism known, seems to be an extremely logical candidate as a cause of neoplastic proliferation.” 


pH of the blood is the most important factor to 
determine the state of the microorganisms in the blood. 


“Sodium bicarbonate therapy is harmless, fast and effective because it is extremely diffusible. A therapy with bicarbonate for cancer should be set up with strong dosage, continuously, and with pauseless cycles in a destruction work which should proceed from the beginning to the end without interruption for at least 7-8 days. In general a mass of 2-3-4 centimeters will begin to consistently regress from the third to the fourth day, and collapses from the fourth to the fifth,” says Dr Simoncini. 


There are many ways to use sodium bicarbonate and it is a universal drug like iodine and magnesium chloride. Raising pH increases the immune system’s ability to kill bacteria, concludes a study conducted at The Royal Free Hospital and School of Medicine in London. Viruses and bacteria that cause bronchitis and colds thrive in an acidic environment. To fight a respiratory infection and dampen symptoms such as a runny nose and sore throat, taking an alkalizing mixture of sodium bicarbonate and potassium bicarbonate will certainly help.  


The apple cider vinegar 1/4 teaspoon and 1/4 teaspoon baking soda taken 2 times or more a day is another treatment as is lemon and baking soda, or lime and baking soda formulas. Perhaps honey could be substituted for maple syrup for those who live in parts of the world where maple syrup is not available but to my knowledge no one has experimented with this.  



Mark Sircus Ac., OMD 
Director International Medical Veritas Association  


This article is from the 850 page e-book Winning the War on Cancer  

About Cesium Chloride High-pH Therapy

Otto Warburg won a Nobel Prize for showing that cancer thrives in anaerobic (without oxygen), or acidic, conditions. Research by A. Keith Brewer, PhD and H.E. Sartori has shown that raising the pH, or oxygen content, range of a cell to an alkaline range of 8.0 creates a deadly environment for cancer. Dr. Brewer found that the use of cesium chloride (CsCl) was an excellent way to boost alkalinity (i.e., oxygen levels).  

The pH scale ranges from 0 to 14. Numbers below 7 represent acidic conditions while numbers above 7 represent alkaline conditions, also known as oxygenated conditions.  

When cesium is taken up by cancer cells it raises the pH level of the cell, thereby boosting the oxygen content. The cancer cells die and are later eliminated by the body.  

In 1984, Dr. A. Keith Brewer explored high-pH therapy through the use of salts of cesium and rubidium together with potassium supplements. He tested the therapy and found it effective on cancers in both mice and humans.  

Dr Brewer’s findings were described in the article “The High pH Therapy for Cancer—Tests on Mice and Humans.” In the article, he reported tumor masses disappeared after several weeks of exposure to cesium chloride. He also stated, “The immediate effect of the cancer therapy is to lessen the pain and side effects of the tumor. This is a result of the cesium neutralizing the effects of toxic enzymes which leak out of the cancer cells … all pains and effects associated with cancer disappeared within 12 to 36 hours.  

“There can be no question that [when] Cs and Rb salts [are] present in the adjacent fluids, the pH of cancer cells will rise to the point where the life of the cell is short, and that they will also neutralize the acid toxins formed in the tumor mass and render them nontoxic.”  

Dr. Brewer’s patients ingested 3 to 6 grams of cesium chloride (CsCl) or rubidium chloride (RbCl) daily together with 2 to 4 grams of potassium chloride (KCl) and a variety of other nutritional supplements.  

“The toxic dose for CsCl is 135 g. The administration of 6 g per day therefore has no toxic effects. It is sufficient however to give rise to the pH in the cancer cells, bringing them up in a few days to 8 or above where the life of the cell is short. In addition, the presence of Cs and Rb salts in the body fluids neutralizes the acid toxins leaking out of the tumor mass and renders them nontoxic.”  

The daily dose of mineral salts is divided into three parts, and consumed during or following each meal.  

Dr. Brewer writes: “Many tests on humans have been carried out by H. Nieper in Hannover, Germany and by H. Sartori in Washington, DC as well as by a number of other physicians. On the whole, the results have been very satisfactory. It has been observed that all pains associated with cancer disappear within 12 to 24 hr, except in a very few cases where there was a morphine withdrawal problem that required a few more hours. In these tests 2 g doses of CsCl were administered three times per day after eating. In most cases 5 to 10 g of Vitamin C and 100,000 units of Vitamin A, along with 50 to 100 mg of zinc, were also administered. Both Nieper and Sartori were also administering nitrilosides in the form of laetrile. There are good reasons to believe that the laetrile may be more effective than the vitamins in enhancing the pickup of cesium by the cells.  

“In addition to the loss of pain, the physical results are a rapid shrinkage of the tumor masses. The material comprising the tumors is secreted as uric acid in the urine; the uric acid content of the urine increases many fold. About 50% of the patients were pronounced terminal [prior to this treatment], and were not able to work. Of these, a majority have gone back to work.  

“Two side effects have been observed in some of the patients. These are first nausea, and the second diarrhea. Both depend upon the general condition of the digestive tract. Nieper feels that nausea can be prevented by administering the cesium in a solution of sorbitol. The diarrhea may, to some extent, be affected by the Vitamin C.”  

Dr. Brewer described one case history:  “A woman with 2 hard tumor masses 8 to 10 cm in diameter, one on her thyroid and one on her chest, was given 3 to 6 months to live. She had been subjected to chemotherapy, but was discontinued because it weakened her. She was taking laetrile on her own. She was given a 50 g bottle of CsCl and was told to take 4 g per day. She reported her case a year later. Being very frightened she took the entire 50 g in one week. At the end of that time the tumor masses were very soft, so she obtained another 50 g of CsCl and took it in another week. By the end of that time she could not find the tumors, and two years later there was no sign of their return.”  

Similarly, he talked about the Hopi Indians of Arizona and natives in Central and South America:  

“The incidence of cancer among the Hopi Indians is 1 in 1000 as compared to 1 in 4 for the USA as a whole. Fortunately their food has been analyzed from the standpoint of nutritional values. In this study it was shown that the Hopi food runs higher in all the essential minerals than conventional foods. It is very high in potassium and exceptionally high in rubidium. Since the soil is volcanic it must also be very rich in cesium.  

“The Indians who live in Central America and on the highland of Peru and Ecuador have very low incidences of cancer. The soil in these areas is volcanic. Fruit from the areas has been obtained and analyzed for rubidium and cesium and found to run very high in both elements.”  

It is recommended anyone wishing to take cesium chloride should first consult with a physician, as the mineral must be supplemented by a balance of potassium in order to avoid developing conditions such as ventricular tachyarrhythmia.  SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

  • *High pH Cancer Therapy With Cesium by A. Keith Brewer, available from the A. Keith Brewer International Science Library, 325 N Central Avenue, Richland Center, WI 53581  
About Dimethyl Sulfoxide (DMSO)

Related to MSM, DMSO is different enough to be placed in its own category. It is a solvent with the ability to penetrate living tissue and thereby transport different medicines in their original state to other areas within the body. It is most commonly used as a vehicle for topical drugs. 

Research has shown that DMSO may slow the progression of cancer cell proliferation, though conclusive proof is lacking. DMSO has also been used to prevent the accidental administration of intravenous-infused chemotherapeutic agents from leaking into surrounding tissues. 

Many researchers view DMSO’s capabilities as a new principle in medicine that is, as yet, largely untapped. See DMSO and MSM. SOURCE: Alternative Cancer Research Institute 

Further Reading & References 

  • Jacob SW,.Herschler R. Pharmacology of DMSO. Cryobiology 1986; 23:14-27. 
  • Brayton CF. Dimethyl sulfoxide (DMSO): a review. Cornell Vet. 1986; 76:61-90. 


About Falk Supplementation Schedule – High Dose Vitamin C

The Falk Supplementation Schedule (from the Falk Oncology Center in Toronto, Canada) comprises:  

  • • Vitamin C (fine crystals, minimum 4 grams (4,000 mg) three times per day. Aim for a dose just below diarrhea level, up to 40 grams per day. 1 level teaspoon = 4 grams. For most Vitamin C, however check the label)  
  • Niacinamide 500 mg three times per day. (If cholesterol is high, use niacin.)  
  • Vitamin B Complex (50′s) once a day (sublingual B12 is the best form of B12, especially if you are over 35).  
  • Vitamin E 400 IU once a day  
  • Beta Carotene 25,000 IU once a day  
  • Cod Liver Oil 2 capsules once a day  
  • Zinc Citrate 50 mg twice a day  
  • Selenium 200 mcg three times per day  
  • Folic Acid 5 mg twice a day  
  • Potassium increase to 1 gram once a day  
  • Magnesium Oxide 420 mg once a day  
  • Lactobacillus acidophilus.  

The now deceased oncology therapist Dr. Rudy Falk also repeatedly stated: “The greatest use of Poly-MVA is as a cancer prophylactic.”  

See Poly-MVA. 

Further Reading & References  


About Hydrazine Sulfate

Dr. Joseph Gold’s approach to cancer is based on interfering with cachexia, the medical term for the severe malnutrition or emaciation that may affect up to 90% of all advanced cancer patients and account for 50% of all cancer deaths. A layman’s term for cachexia would be “wasting away.”  

Dr. Harold Dvorak, chief of pathology at Beth Israel Hospital in Boston notes: “In a sense, nobody dies of cancer. They die of something else – pneumonia, failure of one or another organs. Cachexia accelerates that process of infection and the building up of metabolic poisons. It causes death a lot faster than the tumor would, were it not for the cachexia.”  

Dr. Gold drew on the work of two-time Nobel Prize winner, Otto Warburg, who theorized that cancer derives its energy from fermenting glucose. Dr. Gold concluded that cancer imposes a waste recycling system on the liver and kidneys.  

The process works like this: cancer uses glucose as its fuel. The waste product that emerges is lactic acid that is excreted into the blood system and is taken up by the liver and kidneys. The lactic acid is then reconverted back into glucose by a process that requires a great deal of energy. The more glucose that is created the more fuel the cancer has to feed on and the more waste products that return to the liver for re-conversion. This process depletes the body and energizes the cancer. When the body cannot keep up, the result is cachexia, or wasting away.  

Dr. Gold looked for a drug that would interfere with this process. He settled on hydrazine sulfate as the solution. His experiments showed that hydrazine sulfate did indeed have an effect on the cancer energizing process.  

His first human volunteer in 1973 was a woman who was expected to die within a matter of days from Hodgkin’s disease. She was completely bed-ridden and, not having eaten much for some time, was ‘paper-thin’. Administration of the drug resulted in very quick improvement. Within a week, she was shopping, within five weeks she was back in her garden.  

Dr. Dean Burke of the National Cancer Institute in Washington declared: “[Hydrazine sulphate is] the most remarkable anti-cancer agent I have come across in my forty-five years of experience of cancer.”  

Hydrazine sulphate eventually wound up on the American Cancer Society’s list of unproven therapies, in effect a list of banned treatments. This was despite the evidence that Gold put forward to support its value.  

Dr. Gold analyzed 84 terminally ill cancer patients who had been treated with hydrazine sulfate under a drug company’s investigational new drug (IND) license. 70% showed subjective improvements (i.e. decreased pain, improved appetite, weight gain or stoppage of weight loss, and increased strength) and 17% had objective improvements (tumor regression, disappearance of cancer related disorders).  

Russian scientists at the NN Petrov Research Institute of Oncology in St Petersburg have replicated these results. In 1974, they used hydrazine sulfate on 48 patients who were considered terminal.  

They found that almost 60 per cent felt subjectively much better, indeed euphoric. Their appetites improved and the pain lessened or disappeared. Over half of these had clear signs of tumor control.  

The Russian team also found another interesting attribute of hydrazine sulfate. They found that it appeared to make cancers more vulnerable to chemotherapy, even in the case of tumors that had previously been resistant to chemotherapy.  

In 1985, Tim Hansen, an eleven-year-old boy with three inoperable brain tumors, was given one week to live. A few weeks later, he was put on hydrazine sulphate. Ten years later, he was alive and still taking the hydrazine sulfate as the tumors were still in evidence.  

Studies show that it works against every kind of tumor at every stage. There is an abundance of published, positive, peer-reviewed studies on hydrazine sulfate in the medical literature. Hydrazine sulfate has been demonstrated to produce only few and fleeting side effects. Advocates claim there have been no instances of bone marrow, heart, lung, kidney or immune system toxicity, or death. Hydrazine sulfate has never been shown to be carcinogenic in humans.  

Dr. Gold’s recommended dosage for adults weighing over 100lbs is 60 milligrams per day for the first three days, then 60 milligrams twice a day for the next three days, and 60 milligrams three times a day thereafter. This treatment must continue for as long as there is evidence of a tumor in the body.  

No dose higher than 60 milligrams is to be tried as this can cause nerve damage. Alcohol, tranquilizers, and barbiturates must not be taken during the course of treatment as these inhibit the action of the drug. For patients weighing less than 100 lbs., the dosage should be halved. SOURCE: Alternative Cancer Research Institute 


Further Reading & References  

About Radiofrequency Ablation (RFA)

Radio frequency ablation (RFA) is a medical procedure where part of the electrical conduction system of the heart, tumor or other dysfunctional tissue is removed using high frequency alternating current to treat a medical disorder.  

High-frequency electric current is used to heat tumors from within, a process referred to as “cooking the tumor to death” (McCullough 2001). In cardiology, high frequency radio waves have been used for decades to ablate cardiac nerves in patients with dangerous heart rhythms that resisted drug therapy.  

The concept merged into oncology with radiofrequency ablation (RFA) initially used to provide palliative relief to inoperable, terminal patients, particularly those with liver cancer.  

Momentum is growing for the technique, and the therapeutic focus is changing as well. So strong are the prospects for RFA that this pioneering treatment appears (according to researchers) to have the potential to replace both surgery and radiation therapy. Because of its therapeutic value and cost effectiveness, along with its noninvasive, low-risk profile, RFA has the attention of both physicians and patients.  

The National Institutes of Health consider RFA the most predictable, safest, and simplest method for thermal ablation in bone, liver, kidney, prostate, breast, and brain cancers.  

Using open MRI, doctors gain access to the tumor through a needle puncture, a process requiring no surgery. Using specially designed titanium or stainless steel instruments, doctors are directed by the MRI image to the site of malignancy. A titanium electrode is guided to the tumor and enough heat is generated (just below the boiling point) to kill the cancerous cells. After 10-12 minutes of continuous contact with the tumor tissue, the radiofrequency energy “cooks” a sphere of 1-2 inches. By “cooking” adjacent spheres, larger tumors can be treated.  

Dr. Jonathan Lewin, director of magnetic resonance imaging at University Hospitals of Cleveland, says that tumorous areas that earlier appeared white are now black, a black hole of dead tumor tissue. It is immediately possible to determine the amount of tumor destruction and to plan treatments (should additional treatment be necessary).  

The dead cells are not removed, but become scar tissue and eventually shrink. The procedure is done under local anesthesia, with minimal discomfort to patients. There are no cumulative dose effects as with radiation therapy, so patients can be treated repeatedly if the cancer returns to other sites. Hospitalization is usually limited to several hours rather than days.  

Dr. Patrick Sewell (University of Mississippi Medical Center) performed this procedure on nine lung cancer patients in China, ranging in age from 38-78 years. Five had primary tumors, two had primary lung tumors with metastasis, and two had metastasized cancer that had spread to the lungs from other locations. When the PET scans came back (3 days following treatment), all tumors had been killed (Sewell 2000).  

At the 85th Annual Meeting of the Radiological Society of North America (Chicago), Dr. Tito Livraghi of Vimercate Hospital, Italy, presented the results of a study designed to evaluate the efficacy of RFA in breast cancer-to-liver metastasis. The study consisted of 15 lesions in 10 patients (average age 51 years). Eight of the patients had progressive metastatic disease following chemotherapy; two patients with hepatic metastasis had not undergone chemotherapy.  

Following RFA, the value of the treatment was assessed by biphasic helical computed tomography (CT) performed at 4-month intervals. Complete necrosis was obtained in 14 out of 15 lesions (93%).  

Follow-up imaging studies (at 4-30 months) were unable to detect a recurrence in any of the 14 lesions.  

Four patients have remained disease free; five (later) have developed new hepatic and/or extra- hepatic metastasis; and one has died with diffuse metastasis. RFA resulted in no treatment-induced complications (Pullen 1999).  

Early results (from an NIH Clinical Center Study) look promising for the use of RF energy in patients with certain kidney and adrenal tumors. Of 18 kidney tumors treated, 13 (72%) showed no x-ray evidence of residual tumors immediately following treatment. One patient remained cancer-free 2 years following treatment. In a related NIH study involving adrenal gland tumors, 7 of 11 tumors (64%) showed no active disease following RFA. Though the remaining 36% of patients had evidence of residual tumors on follow-up imaging, all patients treated had x-ray confirmation that most of the targeted tumor was killed by treatment (Healthlink 2000). SOURCE: Alternative Cancer Research Institute 


Further Reading & References  

About the Burzynski Treatment Program

Dr. Stanislaw Burzynski is both a doctor and a biochemist who works in Houston, Texas. His groundbreaking discovery was a group of peptides and amino acid derivatives occurring naturally in our bodies that have the effect of inhibiting the growth of cancer cells. Burzynski calls these peptides ‘antineoplastons’. They have the effect of “reprogramming” cancer cells to die like normal cells.  

Dr. Burzynski theorized that certain anti-neoplastons, or naturally occurring peptides, could inhibit the growth of tumor cells without interrupting normal cell growth. Burzynski first isolated his antineoplastons from human urine and later synthesized these compounds in the laboratory. He uses about 10 types of antineoplastons in both oral and intravenous fashion.  

In Burzynski’s view, there is a biochemical defense system, completely different from the immune system, that allows defective cells to be corrected through biochemical means. Antineoplastons are at the heart of this defense system. Blood samples from cancer patients show that they have only 2-3% of the amount typically found in a healthy person.  

Burzynski’s method requires the injection of antineoplastons into the bloodstream. The result is tumor shrinkage and even remission. Often this occurs in a matter of a few weeks. In an interview, Burzynski stated that excellent results are obtained for prostate cancer and brain cancers, specifically childhood gliomas.  

When interviewed, Burzynski reported excellent results for prostate and brain cancers and childhood gliomas in particular. He also said he was impressed with sustained-response results for non-Hodgkin’s lymphomas (80% of tumors reduced by 50%) and pancreatic cancers (70% of tumors reduced by 50%).  

The treatment also achieves significant (although lesser) success with breast cancer, lung cancer and colon cancer.  

These rates of success do not represent cures, but “responses” to the treatment, generally meaning tumor shrinkage. There was a chance the cancers could recur.  

In humans, normal cells die off after 20 to 60 divisions. They enter a terminal differentiation at that point and die. In animals, they can sometimes revert, but not in humans.  

According to Burzynski, cancer cells do not die as long as cell division continues. Tumors grow as long as cells remain, in a sense, immortal. When cells are highly malignant, between 20 and 60 divisions can happen very quickly. Since the goal is to have them quickly die while seeing the tumor reduce in size, it is important to force differentiation.  

He believes this is the reason behind the positive results he achieved with glioblastomas and pancreatic cancers. They’re particularly fast-moving cancers. In breast cancer, where one finds slower tumor growth, it takes much longer to see results unless chemotherapy or interferon are also administered.  

Burzynski has only been able to explore a small corner of the research that antineoplastons open up.  

At present, antineoplastons bring benefit to only a portion of patients seeking help at the Burzynski Clinic, most of whom are suffering not only from advanced disease but also from the toxic side effects of previous cancer treatment. Burzynski’s frank advice to one patient with metastatic ovarian cancer  

was that she probably would not benefit from his therapy. Other people have been urged not to come, and this honest approach to accepting patients is greatly to his credit. This is in marked contrast to conventional medicine, where hundreds of thousands of dollars are expended on inefficacious treatments of terminal patients.  

In one study of 20 patients with astrocytoma, mostly in an advanced stage, four went into early remission, two showed partial remission, and ten showed stabilization i.e. tumor regression of less than 50%. Some of these subsequently went on to complete remission. Burzynski holds more than twenty patents and has had more than 150 papers published.  

Nevertheless, the FDA and the American Cancer Society consider him a quack. Some insurance companies refuse to cover his treatments. Antineoplaston was placed in the ACS’s Unproven Therapies list in 1983. This is equivalent to being blacklisted in the conventional medicine community. Yet even official reports show that Burzynski’s treatment has resulted in objective improvements in 86% of advanced cancer patients.  

The FDA took him to court in 1983. He was allowed to continue his work, but only in the State of Texas – and none of his drugs could be shipped across state lines. In 1985, the FDA raided his Institute armed with illegal search warrants and seized 200,000 confidential documents. They have never been returned. The doctor was acquitted by a jury of all charges. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

  • The Burzynski Clinic  
  • The Burzynski Breakthrough: The Most Promising Cancer Treatment … and the Government’s Campaign to Squelch It by Thomas D. Elias (2000)  
  • The Cancer Industry by Ralph W. Moss Ph.D.  


About the Issels Protocol

Dr Josef Issels (1907-1998) of Germany was a pioneer in alternative cancer treatment who established what he called a whole-body therapy to deal with the whole-body problem of cancer. The therapy combined ozone-oxygen treatments, diet, fever therapy and even low dose chemotherapy and radiation.  

His theoretical basis is as follows. The body has four interrelated defense systems. First, there are the lymphocytes and antibodies that are normally considered to be the entire immune system. Secondly, there are the eliminating and detoxifying organs: liver, kidneys, skin, and intestine.  

Third, there are friendly bacteria in the epithelial tissues of the body and lastly there is the connective tissue where organic salts are stored and toxins are digested or bound chemically to make them inert.  

Dr. Issels made a big point of insisting that infected teeth and tonsils should be removed – including all teeth filled with mercury amalgam and teeth whose pulp has been removed through root canal treatment. He believed that these impair the immune system.  

Dr. Issels achieved remarkable remissions, even in advanced cases, through a combination of therapies designed to shrink the tumor and repair the body’s defense mechanisms. His “whole body” approach included anticancer vaccines, an anticancer diet emphasizing organic raw foods, and fever therapy to stimulate immune function. He also used a variety of methods to rebuild the immune system and change the body’s biochemistry to eliminate an environment favorable for the development of cancer.  

Occasionally he also used very low-dose chemotherapy, surgery, radiation, and ozone therapy in combination with immunotherapy. He prescribed organ extracts to repair damage to organs and improve their functioning. He also administered organ-specific RNA and DNA, proteolytic enzymes to destroy the protein coat surrounding tumors, as well as vitamins and minerals to strengthen the body’s enzyme activity.  

His program also includes psychotherapy to deal with the emotional factors that he felt could hinder recovery.  

Dr. Issels gave patients a “fever shot” once a month to raise the body temperature as high as 105 F. He induced active fever with the ethical drug Pyrifer, made from specially treated coli bacteria. He induced passive fever by means of hyperthermia – the patient was placed inside a cylinder containing electrodes that bombarded his or her body with ultra short waves.  

He tried to motivate cancer patients to wage a fulltime struggle against cancer. As one example, his cancer patients were routed out of their beds to do light mountain climbing in the Bavarian Alps. The patients also participated in a daily exercise regime that included jogging.  

Two independent studies – one at King’s College Hospital in London, the other at the University of Leyden in Holland – confirmed that about 17% of Issel’s incurable, terminal patients led normal, cancer-free lives for at least five years. Their life expectancy upon admission had been less than one year. Comparable five-year survival figures for conventional chemotherapy and radiation treatment are less than 2-3%.  

Here are 5-year survival statistics as depicted at 

For incurable patients:  

  • 2% survived with conventional treatment  
  • 17% survived with Issels’s treatment (these “incurable” cancer patients went on to lead full cancer-free lives, some for up to 45 years.)  
  • Of 370 patients with various cancers who received the Issels treatment as a follow-on to conventional cancer treatments, only 13% suffered a recurrence of their cancer compared to an expected recurrence rate of 50%  

Dr. Issels with his Whole Body Therapy achieved, as published in the Clinical Trials Journal:  

  • 87% five-year survival with non-metastasized cancer patients, in a study published in Clinical Trials Journal (London), 1970, 7, No. 3  
  • 16.6% five-year survival with late-stage cancer patients, in a study published in Die Medizinische 1959, No. 40  
  • 17% five-year survival with late-stage cancer patients, in a study published in General Practitioner, March 1971  

These are good survival figures for late-stage cancer patients.  

In the 1950′s and 60′s, the German medical establishment boycotted and isolated Dr. Issels. Finally, the German medical authorities leveled trumped-up charges of fraud and manslaughter against him, and in 1960, he was imprisoned. Eventually, however, he was acquitted of all charges. Dr. Josef Issels died in California on 11 February 1998, a few weeks after his 90th birthday.  SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

  • Issels Hypothesis of the Pathogenesis of Cancer by Dr. Josef Issels  
  • Dr. Issel’s textbook – Cancer, A Second Opinion by Dr. Josef Issels  
  • Issels, J. Immunotherapy in Progressive Metastatic Cancer – A Fifteen-Year Follow-up. Clinical Trials  
  • Journal, August 1970: 357-365 – editorial by Phillips S. Dr Joseph Issels and the Ringberg Klinik 
  • Cancer – Whole-body Approach and Immunotherapy, lecture given in New York, 1980, by Dr. Josef Issels 
  • Cancer Cure Foundation: The Issels Cancer Treatment, htm  
  • The Cancer Industry by Ralph W. Moss Ph.D.  
  • Cancer Therapy by Ralph W. Moss Ph.D. (1992)  
  • Richard Walters: Options. The Alternative Cancer Therapy Book.  
  • Third Opinion (Fourth Edition) by John M. Fink (2010)  
What is Honokiol Extract (Magnolia Tree)

Medicinal plants are known to be the source of many common pharmaceuticals. Drugs derived from the plant kingdom include aspirin from white willow, digitalis from foxglove, morphine from poppy, and chemotherapy agents like vincristine from periwinkle and taxol from the yew. Many herbs and plants also play a supportive role in conjunction with conventional cancer therapy. One such natural compound is honokiol, extracted from the magnolia tree. Traditionally used in Japanese and Chinese herbal medicines, honokiol has been found to be a powerful, versatile tool in integrative cancer treatment. 

A highly active compound derived from magnolia bark, honokiol has been used in Traditional Chinese Medicine (TCM) for treating digestive disorders, anxiety and other chronic conditions. Over the last decade or so, honokiol has been the subject of extensive research as an adjuvant cancer treatment, demonstrating remarkable benefits through diverse mechanisms of action. The compound shows promise for a number of solid tumors and hematological cancers and appears to be particularly effective in reversing multi-drug resistance and synergizing with other treatments. 

Mechanisms of Action 

A growing body of data demonstrates honokiol’s multiple mechanisms of action against cancerHonokiol appears to be particularly active in regulating cell cycle arrest and promoting apoptosis (programmed cancer cell death) by inhibiting a number of cancer signaling pathways. 

A July 14, 2008 article in Science Dailyreported on research from Emory University in Atlanta showing that this natural magnolia compound interferes with a critical pathway for cancer growth that was previously considered “undruggable.” Specifically, it blocks survival signals from a difficult-to-target family of genes in breast, lung and bladder cancer cells.1 

A comprehensive 2011 review highlights the multiple pathways by which honokiol influences apoptosis and inhibits multiple cancer cell types  including breast, prostate, colon, liver, lung and others.2 In non-small cell lung cancer, honokiol inhibited cancer growth and induced apoptosis.3 In leukemiahonokiol promoted cell cycle arrest and apoptosis by blocking cancer survival signals.4 A 2012 study showed honokiol halted growth and metastasis of melanoma.5 Another study demonstrated that honokiol-induced cell cycle arrest irrespective of the hormone sensitivity of prostate cancer cells.6 

Honokiol can also inhibit tumor angiogenesis by modulating various signaling pathways that promote cancer cell growth. Honokiol has been shown to inhibit the spread of cancer cells through the lymph system by inhibiting one of the primary pathways involved in growth stimulation related to VEGF (vascular endothelial growth factor).7 A 2012 study showed that honokiol inhibited angiogenic pathways to slow the spread of gastric cancer.8 

Another 2012 study showed honokiol’s direct cytotoxic activity, showing the compound attacked metastatic bone cancer cells directly.9 Honokiol is highly bioavailable and its small molecular size allows it to reach target tissues and cross the blood-brain and blood-cerebrospinal fluid barriers, making it an excellent adjunct for brain tumors like gliomas and neuroblastomas.10, 11 

Synergistic with Cancer Treatments 

One of honokiol’s most important attributes is its ability to act synergistically with conventional cancer treatments. Numerous studies show the remarkable ability of honokiol to enhance the effectiveness of radiation and certain chemotherapy drugs in a number of cancers, including the following studies conducted between 2005 and 2013 which demonstrated that honokiol: 

  • Synergized with chemotherapy drugs in multidrug resistant breast cancer12 
  • Sensitized treatment-resistant colon cancer cells to radiation therapy13 
  • Enhanced the action of cisplatin against colon cancer14 
  • Re-sensitized cancer cells to doxorubicin in multidrug resistant uterine cancer15 
  • Performed synergistically with the drug imatinib against human leukemia cells16 
  • Sensitized cancer cells to radiation treatments17 
  • Potentiated the activity of cisplatin in animal models of ovarian cancer18 
  • Enhanced the cytotoxicity of drugs used for B-cell chronic lymphocytic leukemia19 

Anti-inflammatory and Antioxidant Protection 

In addition to its direct anticancer actions, honokiol is also shown to offer other valuable anti-inflammatory and anti-oxidative effects that relate to its mechanisms against cancerHonokiol offers powerful free radical scavenging benefits against reactive oxygen species.20,21 Its inhibition of reactive oxygen was actually shown to be 1,000 times that of α-tocopherol (vitamin E).22 (Interestingly, honokiol is also a selective pro-oxidant, generating reactive oxygen against certain cancer cells. The ability of honokiol to function either as an antioxidant or a pro-oxidant depending on the need is one of its most remarkable features.) A 2005 study suggested honokiol can protect the brain against amyloid plaque neurotoxicity in the formation of Alzheimer’s disease23 by reducing inflammation and oxidation in the brain. 

Source and Dosages 

The most concentrated and purest source of honokiol is HonoPure by EcoNugenics, offering 98% pure honokiol extract for multiple indications. The company has agreed to clients a 15% discount on honokiol, as well as their entire line of products for prostate health, breast health, immune support, hormonal support, and heavy metal detoxification, among others.  

 Below are suggested dosages according to clinical use guidelines: 

  • Active cancer: 1 g x 3/day (starting at lower dosage and building up to full dose) 
  • Cancer prevention/post cancer therapy: 1 g/day 
  • Inflammatory conditions: 250-500mg x 2/day 
  • Anxiety: 250 mg x 2/day 

Honokiol’sin vivo toxicity record thus far shows it to be extremely safe. 


The research on this remarkable compound continues to show beneficial effects for numerous serious and difficult-to-treat conditions, including protection against neurological conditions like Alzheimer’s disease23 and stroke damage,24viral and bacterial infections like hepatitis C, 25-26 and multiple drug resistant cancer. It is currently used clinically by a growing number of integrative and naturopathic physicians. SOURCE: Science Daily – Emory University – July 14, 2008 


Xu HL, Tang W, Du GH, Kokudo N. Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis. Drug Discov Ther. 2011 Oct;5(5):202-10. [3] Singh T, Prasad R, Katiyar SK. Inhibition of class 1 histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo. Epigenetics. 2013 Jan1;8(1):54-65. 
[4] Ishikawa C, Arbiser JL, Mori N. Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia. Biochim Biophys Acta. 2012 Jul;1820(7):879-87. 
[5] Kaushik G, Ramalingam S, Subramanium D, Rangarajan P, Protti P, Rammamoorthy P, Anant S, Mammen JM. Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells. Am J Surg. 2012  



The Survival Triangle

I call my three pillars to beat cancer the “survival triangle.” If you’re serious about keeping (or getting) cancer out of your life, follow these steps to better health. They are simple, proven fighters that will make you a winner against this devastating disease. Taking a single one and making it part of your life will make a huge difference in your overall health.

If you utilize all three, it will change your life.

Now, before anything, let me say that traditional cancer treatment (surgery, chemotherapy, and radiation) does its part to help patients survive cancer.

Unfortunately, they don’t address the root cause of cancer. They treat the tumors that result. They kill the cancer cells and a lot of healthy cells along the way. Conventional cancer modalities treat the disease…not the patient.

Even oncologists who understand that toxins and inflammation are the underlying cause of millions of deaths globally from cancer every year aren’t addressing prevention techniques that will keep these patients from coming back with another cancer in a year or five years.

Addressing the “Alternative Medicine Skeptics”

If you don’t address the cause – the problems that start the cancer ball rolling – then you haven’t really beaten it…you’ve only managed to knock it unconscious for a while.

You have to take control of your health. That requires you to understand how your body works and what it needs to do the best job for you that it can.

If you don’t “believe” in alternative therapies, then you’re doing yourself a great disservice. Even if you fully expect traditional treatment to “cure you,” alternative methods can help you with the side effects you’re going to experience, keep your body stronger, and guard you against another episode of cancer in your future.

Alternative choices can improve your quality of life and help you endure treatments such as radiation that leave the body (and immune system) ravaged and weak. The “war” against cancer leaves as much destruction as a real war. Much like the natural landscape and infrastructure is left annihilated in battle – so is your body after traditional treatment.

Pillar #1 – DIET

Cancer represents the biggest fight of your entire life.  You need to be as fit and healthy as you can be to meet the challenge. In order to handle the demands of exercise, to terminate infection and bacteria, to fight the effects of age, your body is going to need the right fuel.

That is why diet is the first pillar of beating the root causes of cancer.

Anyone (medical professional or otherwise) who tells you that diet does not affect your health or ability to fight disease is a liar. Period.

Diet is everything. Even the World Health Organization (WHO) estimates that around 40% of cancers are caused by diet (I think the numbers are actually much higher). What you choose to put in your mouth may mean the difference between life and death.

That isn’t dramatic, that is fact.

Eating a diet filled with junk food, dyes, preservatives, excess sugar, caffeine, or other “empty” calories cannot and will not feed your body. If your body doesn’t get the right vitamins and minerals – it stops running. Just like a car without gas.

There are many anti-cancer meal plans that I discuss in my books and on but there is no universal diet plan that will suit every person equally. Instead, dietary requirements must be assessed based on each individual’s specific needs. Remove any foods (no matter how much you love them) that cause stress to your immune system.

My personal suggestion is to fill your diet with fresh, organic foods (where possible), salads, smoothies, and brightly colored produce. Remember that dairy, soy, grains, and even certain produce can be unknown stressors. Avoid white sugar, white flour, white rice, processed foods, dairy, and soy.

Pillar #2 – Emotional Cleansing

Negative emotion as a root cause of cancer is reality. There is far too much science to back this stance up, so keep an open mind.

Stanford psychiatrist, Dr. David Spiegel, was a skeptic when he began his study on the influence of negativity on breast cancer patients. He was shocked to discover that at the ten-year survival checkup, those women who included therapy in their lives survived twice as long as those who did not.

You read that right…there was a 50% better survival rate by purging negative emotion.

Another Yale research study found that cancer spread faster in women who had “repressed personalities.” They defined the word “repressed” as having intense feelings of hopelessness and not having the ability to express anger, fear, or other negative emotions.

In other words, they bottled it all up inside and it made them sicker, faster.

Stress is known in the traditional and alternative communities as a major cause of inflammation. It is one thing everyone agrees on (though traditional medicine’s answer is another prescription). Inflammation has been discovered at the base of all known diseases.

In other words, stress will kill you through cancer or heart attack or autoimmune disease…if you allow it to control your life. Balanced emotions equal a balanced physiological system.


There are countless stressors in our modern world and many of them are foods, people or situations, and products we allow into our lives. We’ve talked about the first two. Let’s discuss the contamination most people never consider.

Personal pollution is as dire as environmental pollution and we are surrounded by both at every turn. Pollutants are in our soil, water, and air and that means they are in our food supply. Those are harder to control (even organic foods are grown on the same planet we’ve corrupted with countless toxins).

You can control what you put on your body, what you put in your body, and how you maintain the environments you live in most (your home and work space).

If you haven’t heard about the chemical soup found in cosmetics, household goods, and everyday cleansers, I urge you to do some research on it right now. From heavy metals and arsenic to formaldehyde and parabens…products you buy every day at your local market are filled with endocrine disruptors, estrogen mimics, and outright poison to the cells in your body.

One person I urge you to read is Dr. Sam Epstein, a professor of Occupational Health and Environmental Medicine at the University of Illinois School of Public Health.

In his book, The Politics of Cancer, he states, “The NCI (National Cancer Institute) promised annual cancer mortality rates would be halved by the year 2000. The establishment now belatedly admits that cancer rates are increasing sharply. It discounts substantial evidence…the wide range of chemical and radioactive carcinogens permeating the environment, air, water, food, and the workplace. The establishment ignores, let alone investigates, carcinogenic contaminants in dietary fat, particularly pesticides, PCBs, and estrogen (with extensive and unregulated use as growth promoting animals food additives).”

Big Business (food manufacturers, chemical producers, and even personal care manufacturers), and Big Pharma (drugs, drugs, drugs) don’t care about your health. They don’t care about “curing” anything at all because then…how would they make money?

Every time you use cosmetics, shampoos, conditioners, antiperspirants, paints, household cleaning agents, laundry detergent, or any host of other products…you are playing Russian Roulette with your health.

These deadly toxins don’t just pass through your system. No, that would be bad but your (healthy) immune system would be able to control most of the fallout. What makes many of these chemicals so dangerous is that they accumulate in your body, gradually building up (bit by bit) to levels that are toxic according to any agency.

The True Causes of Cancer

There are many things stressing your body each and every day. Junk nutrition, high levels of stress, and chemical contamination push these stressors past the brink of what your body can handle. SOURCE: The Truth About Cancer – Dr. Keith Scott-Mumby – July 11, 2015


What is Tian Xian – a supposed miracle cure? It is very expensive and I can’t find any kind of official statement about its safety or its effectiveness.

This page tells you about Tian Xian – an alternative therapy advertised on the internet for cancer. There is information about

What isTian Xian?

There is very little information available on this alternative remedy, except from the organizations selling it. They describe it as an alternative dietary food supplement. They say it helps to destroy, control and inhibit cancer by strengthening the body’s immune system. There is some information on the Memorial Slone Kettering herbal remedy website. If you are looking for information on the web, it’s worth knowing that Tian Xian is also written Tien Hsien.


Tian Xian is said to be a cocktail of 14 plant extracts, including ginseng and liquorice. It was invented by a Chinese Professor called Wang Zhen Guo. Tian Xian claims to have won many awards. All those listed by the sellers are from the 38th Eureka World Invention Expo, an organisation we have not heard of. From the information given by the sellers, this remedy is used mostly in the Far East in places such as Hong Kong, China and Malaysia.

The websites selling this product claim that it has been scientifically tested. But these claims are not backed up by any hard evidence. There are no statistics on survival presented. Nor are there any descriptions of controlled clinical trials . A randomised trial is the only way to properly test whether any new drug or remedy actually works. The only information given about tian xian is that it was found to be not inferior to 5FU. Again, no scientific data is given to back this up. What the makers do say is that Tian Xian should be used alongside conventional cancer treatment. It should not be a substitute for chemotherapy, surgery, biological therapy or radiotherapy.

Research into Tian Xian

A few lab studies have looked at Tian Xian with human cells. They show that it may have some immune system effects and may cause cancer cells to die Normal cells have a natural life span but cancer cells carry on multiplying for ever. That’s one of the main differences between cancer cells and normal cells. So substances that encourage them to die off naturally are useful in cancer research. So there is some lab evidence emerging about Tian Xian but no evidence that it works in people yet. As this is a mix of many medicinal herbs, it would be surprising if it didn’t have some effects, but that doesn’t mean it is a cancer cure.

Side effects of Tian Xian

The side effects listed for Tian Xian by sites that sell it are


  • Constipation
  • Diarrhoea, which may contain blood
  • Stomach pain and wind
  • Feeling and being sick
  • Dizziness
  • Racing pulse and raised blood pressure
  • Loss of appetite
  • Piles
  • Aches and pains
  • Rashes
  • Darkening skin if you have liver cancer


This is quite a list, but there are no official medical reports of harm coming to people who take Tian Xian.

Cost of treatment

Tian Xian is expensive. The makers suggest you take it daily for 6 months, or until your cancer has gone. Then, you are supposed to take it 1 month out of 4 for 2 years. Then for 2 months each year for the next 5 years. The price on the web varies between about $700 and $1,000 for 28 days daily treatment. Even at the cheapest estimate, that works out to be over £9,000 for a full course.

About alternative therapies

There is no proper research evidence that Tian Xian works as a treatment for cancer. We are concerned that these potential cures are often sold for a great deal of money. And people with cancer can be vulnerable. It is understandable that patients or relatives will try anything if they think it might work.

We are also dubious about any remedy that claims to work for all types of cancer. There are over 200 different types of cancer and they do vary. Some respond to one type of treatment and others to another. They have different causes and there are different genetic mutations in the cells of different types of cancer. It is very unlikely that anyone will ever come up with a single treatment that works for all cancer types.

About Asparagus and Cancer

Several years ago, I had a man seeking asparagus for a friend who had cancer.  He gave me a photocopied copy of an article, entitled, `Asparagus for cancer’ printed in Cancer News Journal, December 1979.  

I will share it here, just as it was shared with me: ‘I am a biochemist, and have specialized in the relation of diet to health for over 50 years.  Several years ago, I learned of the discovery of Richard R. Vensal, D.D.S. that asparagus might cure cancer..  

Since then, I have worked with him on his project.  We have accumulated a number of favorable case histories.  

Here are a few examples:  

Case No. 1: a man with an almost hopeless case of Hodgkin’s disease (cancer of the lymph glands) was completely incapacitated.  Within 1 year of starting the asparagus therapy, his doctors were unable to detect any signs of cancer, and he was back on a schedule of strenuous exercise.  

Case No. 2: a successful businessman 68 years old who suffered from cancer of the bladder for 16 years.  After years of medical treatments, including radiation without improvement, he went on asparagus.  Within 3 months, examinations revealed that his bladder tumor had disappeared and that his kidneys were normal.  

Case No. 3: a man had lung cancer.  On March 5th 1971, he was put on the operating table where they found lung cancer so widely spread that it was inoperable.  The surgeon sewed him up and declared his case hopeless.  On April 5th he heard about the asparagus therapy and immediately started taking it..  By August, x-ray pictures revealed that all signs of the cancer had disappeared.  He is back at his regular business routine.  

Case No. 4: a woman was troubled for a number of years with skin cancer.  She finally developed different skin cancers, which were diagnosed by asking specialist as advanced.  Within 3 months after starting on asparagus, her skin specialist said that her skin looked fine and no more skin lesions.  This woman reported that the asparagus therapy also cure her kidney disease, which started in 1949.  She had over 10 operations for kidney stones, and was receiving government disability payments for an inoperable, terminal, kidney condition.  She attributes the cure of this kidney trouble entirely to the asparagus.  

I was not surprised at this result, as `The elements of material medical’, edited in 1854 by a Professor at the University of Pennsylvania, stated that asparagus was used as a popular remedy for kidney stones ..  He even referred to experiments, in 1739, on the power of asparagus in dissolving stones.  

We would have other case histories but the medical establishment has interfered with our obtaining some of the records.  I am therefore appealing to readers to spread this good news and help us to gather a large number of case histories that will overwhelm the medical skeptics about this unbelievably simple and natural remedy.  

For the treatment, asparagus should be cooked before using, and therefore canned asparagus is just as good as fresh.  

I have corresponded with the two leading canners of asparagus, Giant and Stokely, and I am satisfied that these brands contain no pesticides or preservatives.  Place the cooked asparagus in a blender and liquefy to make a puree, and store in the refrigerator.  Give the patient 4 full tablespoons twice daily, morning and evening.  

Patients usually show some improvement in from 2-4 weeks.  It can be diluted with water and used as a cold or hot drink.  This suggested dosage is based on present experience, but certainly larger amounts can do=2 0no harm and may be needed in some cases.  

As a biochemist I am convinced of the old saying that `what cures can prevent’.  Based on this theory, my wife and I have been using asparagus puree as a beverage with our meals.  

We take 2 tablespoons diluted in water to suit our taste with breakfast and with dinner.  I take mine hot and my wife prefers hers cold.  For years we have made it a practice to have blood surveys taken as part of our regular checkups.  

The last blood survey, taken by a medical doctor who specializes in the nutritional approach to health, showed substantial improvements in all categories over the last one, and we can attribute these improvements to nothing but the asparagus drink.  
As a biochemist, I have made an extensive study of all aspects of cancer, and all of the proposed cures.  As a result, I am convinced that asparagus fits in better with the latest theories about cancer. Asparagus contains a good supply of protein called histones, which are believed to be active in controlling cell growth.  For that reason, I believe asparagus can be said to contain a substance that I call cell growth normalizer.  That accounts for its action on cancer and acting as a general body tonic.  

In any event, regardless of theory, asparagus used as we suggest, is a harmless substance.  

The FDA cannot prevent you from using it and it may do you much good.  It has been reported by the US National Cancer Institute, that asparagus is the highest tested food containing glutathione, which is considered one of the body’s most potent anti carcinogens and antioxidants. Source: Dr. Gabe Mirkin – Alternative Medicine – February 2009 

What is Poly-MVA?

Results have been released demonstrating the effectiveness of palladium lipoic complexes (referred to as PdLA and its dietary supplement version, Poly-MVA), a safe nutritional approach for cancer – a disease that according to U.N. and American Cancer Society surveys affects some 2 billion people worldwide.  

In a multiple cell line study, Poly-MVA was shown to be immediately effective against numerous cancer cell lines measured over 72 hours: melanoma, liver, lung, breast, colon, astrocytomoa and glioblastoma. In the prostate cancer line, there was no cell death at 24 hours, but there was tumor cell death seen at 48 hours. One significant benefit of Poly-MVA is that it can be continued indefinitely. Research shows the best results appear to be achieved when it is taken for periods of time of 3 months or greater. 

A patented supplement with over 17 years of testing and clinical research, and over 40 years of laboratory research, Poly-MVA is a nutritional supplement that is uniquely formulated combination of minerals, vitamins and amino acids designed to increase cellular energy production, promote overall health and protection, and support immune system function – particularly in compromised body states. 

Poly-MVA is prepared using a unique method that complexes the ingredients and produces a compound that is safe, effective and supports and protects healthy cells. 

Al Sanchez, Jr., the company’s President and CEO, is excited at the continuing evidence showing the effectiveness of Poly MVA with cancer patients. 

“It has been shown through scientific research, case studies, clinical application, practitioner reports and individual responses that Poly-MVA supports and improves cellular function and has far-reaching positive effects on many systems and functions of the body. Its most notable effects have been with cancer patients, but others are having wonderful results as well,” he commented. “The results of the KGK cell lines are further confirming the important role Poly-MVA can have in directly supporting those dealing with cancer.” 

For more information on Poly-MVA, visit 

How Can Poly-MVA Help? 

  • Helps the body to produce energy 
  • Supports the liver in removing harmful substances from the body 
  • Assists in preventing cell damage 
  • Assists the body in removing heavy metals from the bloodstream 
  • Works as a powerful antioxidant and detoxificant 
  • Prevents B-12 deficiency related mental disturbances in the elderly 
  • Supports nerve and neurotransmitter function 
  • Enhances white blood cell function 
  • Supports pH balance, helping to maintain oxygenation of cells and tissues 

Note: Poly-MVA is marketed as a dietary supplement therefore we can not make claims that it treats or cures any disease. All of the information we share in this email comes fromscientific research and field reports from our Health Care Practitioners and individuals who have used Poly-MVA.)   

Please checkout the following WEBSITES: 

Home Website 


Webcasts of Doctors on Poly-MVA 


Foundation Website  



Dr. Garnett’s Website 

Support Group Website 

Survivors Group Website 


Amazing Results of Clinical Trial of Natural Herbal Compound

(Mt. Miriam Hospital, Panang, Malaysia) – A human study of a natural herbal compound which containing 50mg of Graviola (annonaceous acetogenin), 30mg of Maitake (beta glucan), 20mg of Maytenus illicifolia (maytansine), 50mg of Cats Claw, 50mg of Suma (pfaffosides), 15mg of Bitter melon (guanylate cyclase and cucurbitacin B) and 20mg of Mutamba (procyanidin b-2) plus a proprietary formula from GenEpic was conducted on various types of humans breast carcinomas, stage 1 through stage 4. The trial was conducted by Dr. Amir Farid Datuk Isahak MD and Dr. Lee Chui Ai PhD at Mt. Miriam Hospitalin PanangMalaysia. 

Our study spanned six months and involved 210 tests subjects. Due to the time frame involved in the study and the limited number of tests subjects the only requirement of each test subject was a positive mammogram along with an MRI showing a malignant carcinoma in the breast tissue. Our next dilemma was to produce a comparative method to describe what we were seeing. Due to the fact that we were viewing various carcinomas we decided that a total measurement of each subjects tumor thickness, length, and width would be taken and recorded in millimeters, then multiplied by the number of subjects in our study. This number would represent the group as a whole and give us an average size of the whole group.   

Each test subject followed the protocol with monthly interviews and a follow-up MRI after three months with a final after the sixth month. The protocol was three doses of the compound on an empty stomach at 7:00am, 3 doses at 1:00pm, and 3 at 8:00pm 

The following results were seen… 

1st month 

85% of the tests subjects reported a severe reaction to the treatment starting on or about the 5th day. Symptoms included 100% severe fatigue, 22% nausea, 65% headache, 15% skin rash, 10% stiff joints, and 18% bloating and swelling in extremities, 8% diarrhea and 2% stomach cramps. By day 12 over 80% of the symptoms had disappeared while most of the subjects still reported fatigue. It should be noted that many of the patients had reported to their regular physician who subsequently experienced an extreme increase in blood chemical cancer markers during the first few weeks on the protocol. We can only assume this to be a response to the treatment.  

2nd month 

5% of the subjects are still experiencing mild fatigue while 65% have expressed an increase in energy levels. Only 30% remained unchanged. It should be noted that we found during this interview that almost 10% had not followed the protocol on a regular basis. Of these 22 subjects 18 fell into the unchanged category while 4 are still experiencing mild fatigue.  

3rd month 

After reviewing the MRI results from the test subjects we notices a 12% drop in average tumor size. Over 40% of the subjects experienced a 20% reduction or more, while 38% experienced a less than 10% reduction. 7% experienced an average of 3% increase in tumor size while 12% of the group was unchanged. 

4th month  

During month four, 22% of the subjects called in with a reoccurrence of symptoms as expressed in month one. However the severity was drastically reduced to simple headaches, fatigue, and mild diarrhea. 42% of the subjects expressed an increase in energy while the remainder had no particular change in feeling.  

5th month 

During this month 47 of the tests subjects phoned in that a recent mammogram could detect no trace of cancer. We asked each one to continue on the program until we could confirm our results with an MRI.  After the monthly interviews we discovered that 87% had no traceable symptoms of the protocol while 9% were still experiencing headaches. 3% of these subjects have been expressing this since the beginning and on previous health reports before the protocol began complained of migraine like symptoms. 

6th month 

MRI results were conclusive that 178 of the 210 subjects involved have no traceable sign of cancer. 24 of the remaining 32 have experienced a 50% drop in tumor size. Of the remaining eight subjects 3 have experienced a 30% decrease in tumor size while 5 have experienced a combined average increase of 4% in tumor size. All five of these subjects after a consultation have opted to have a complete or partial mastectomy and therefore will not qualify to continue on the protocol.  The 35 remaining subject have agreed to continue with the protocol and a follow-up visit will occur monthly.  

After 12 months of treatment the remaining 35 patient were retested and test results were again conclusive there were no traceable signs of cancer.  The (GenEpictreatment protocol achieved an overall effective rate of remission of 97.7% 

In summary, we feel as if these results warrant a review from the directors of this clinic to not only incorporate this protocol in the standard treatment of breast cancer but also ask that funding be provided to incorporate this program along with clinical protocols into other forms of cancer, such as lung, colon, liver, cervical, uterine, prostate, brain, kidney, pancreatic, esophageal and melanoma. 


Optimal Health Research, a U.S. Company, has begun an FDA approved Institutional Review Board (IRB00008666) to conduct a Controlled Clinical Trial to further determine the potential benefit of this compound (GenEpic™).  GenEpic™ has augmented the original formula by including additional vitamins, herbs, and minerals to boost the immune system during the protocol.  GenEpic™ is available to Health Care Professionals throughout the World that would like to include patients in this IRB. 

For additional information and for a domestic (USA) contact regarding participating in a case study protocol, please contact Dr. Steven Osguthorpe, ND at 801-264-8561, or 


Mt. Miriam HospitalPanangMalaysia 

Clinical abstract of a multi herbal compound from GenEpic 

A herbal compound consisting of 50mg of Graviola (annonaceous acetogenin), 30mg of Maitake (beta glucan), 20mg of Maytenus illicifolia (maytansine), 50mg of Cats Claw, 50mg of Suma (pfaffosides), 15mg of Bitter melon (guanylate cyclase and cucurbitacin B) and 20mg of Mutamba (procyanidin b-2) were tested for their ability to inhibit the growth of adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) cells. These particular cells are resistant to treatment with adriamycin, vincristine, and vinblastine and is, thus, multidrug-resistant (MDR). The NNI compound was most potent with as much as 250 times the potency of adriamycin, a commonly used chemotherapy drug. A dosage of times the written dose seems to be optimum with single doses less active. Several single compounds in this formula have been proven quite potent, with a particular acetogenin known as gigantetrocin A being the most potent compound tested. The acetogenins may, thus, have chemotherapeutic potential, especially with regard to MDR tumors. 

Dr. Amir Farid Datuk Isahak MDDr. Lee Chui Ai PhD  

3 Bromopyruvate And the Metabolic Approach to Cancer

In February, I traveled to Baltimore to interview Peter Pedersen, PhD, and Young Hee Ko, PhD, concerning the metabolic approach to cancer and their formulation of a novel anticancer compound, 3-bromopyruvate (3BP).  
Pedersen is a legendary figure in the field of cancer metabolism. More than any other living scientist, he has elucidated the various ways–normal and abnormal–that a cancer cell generates its energy. Energy production fuels all cells, including cancer cells. Thus understanding the energy production factories inside cells offers the greatest hope for controlling the growth and spread of cancers.  
Pedersen is a seasoned professor of biological chemistry and oncology at the Johns Hopkins University School of Medicine in Baltimore. In addition, he is a member of the Sidney Kimmel Cancer Center, and the Center for Obesity and Metabolism Research, at the same institution. Ko is a former Hopkins researcher who now directs KO Discovery LLC at the University of Maryland’s biomedical research park (BioPark), where we had our meeting.  
Pedersen was born in Oklahoma to a part-Cherokee mother and a Danish-American father. He attended American Indian schools through high school and showed an early aptitude for biology. He had the advantage of having an older brother, Lee, who was already determined to be a scientist. After graduating from the University of Tulsa in Oklahoma, both went to graduate school at the University of Arkansas. Here, Lee majored in theoretical chemistry and Peter in biochemistry. Lee subsequently carried out postdoctoral work at Harvard and later became a celebrated professor at the University of North Carolina.  

While still at the University of Arkansas, Peter Pedersen focused on work related to muscle contraction while learning in required laboratory experiments about the great German biochemist/physiologist Otto H. Warburg, MD, PhD. Warburg won the 1931 Nobel Prize for his pioneering work on cancer metabolism.  
Warburg is generally considered the preeminent biochemist of the first half of the 20th century (Nelson 2008) and was well known for developing an instrument known as the “Warburg apparatus” that was used to measure at a given temperature the amount of gas; for example, oxygen, produced or absorbed by various tissues and cancerous tumors.  
Warburg’s most important discovery was that most animal cells produce energy (conserved in the form of adenosine triphosphate, or ATP) by first converting glucose into carbon dioxide and water. This is done through a process called oxidative phosphorylation, or OxPhos for short. OxPhos, which takes place in specialized cellular bodies called mitochondria, is the culminating step in cellular respiration. But cancer, Warburg found, also utilizes an abbreviated form of energy generation called glycolysis (also known as fermentation). This process produces energy (ATP) by converting glucose into lactic acid. As Pedersen summed it up in our interview: “Most normal animal cells rely heavily on the mitochondria for their energy needs but when transformed to become cancer cells, particularly the most malignant, they rely significantly on both mitochondria and glycolysis.”  
This ability to use both forms of energy generation gives a cancer cell flexibility. It can survive where oxygen is abundant but also where it is in short supply (such as in the interior of a dense tumor). Plus, glycolysis benefits tumors in other ways. For instance, the production of lactic acid as a byproduct helps tumor cells penetrate neighboring tissues or even spread (metastasize). Scientists at the University of Arizona have found that culturing cancer cell lines in even a slightly acidic medium “caused dramatic increases in both migration and invasion” (Martinez-Zaguilan 1996). The cells became more cancerous.  
Pedersen Arrives at Hopkins  
Peter Pedersen began his career as a postdoctoral fellow in the Department of Biological Chemistry of Johns Hopkins Medical School (ranked the nation’s top medical school for research). He had the good fortune to work under Albert L. Lehninger, PhD, a legendary figure in biochemistry and author of Principles of Biochemistry (now in its 9th edition). After completing postdoctoral work in Lehninger’s laboratory, Pedersen focused on understanding how mitochondria make ATP, the major energy source for all cellular–energy requiring processes. As a new faculty member, he then set out two long-term goals related to the study of cancer:  

  1. to explain at a cellular and molecular level the “Warburg effect”; i.e., increased metabolism of glucose to lactic acid even in the presence of oxygen. (That is, even though the mitochondria of cancer cells are capable of making sufficient ATP to fuel/power their growth via OxPhos, such cells also make significant use of glycolysis to help make this ATP.)  
    2. to discover a drug that inhibits both of cancer’s energy-producing factories, OxPhos and glycolysis, while leaving normal cells alone. Then, without their source of energy, the cancer cells that comprise tumors will die quickly and the tumors will disappear.  
    Needless to say, while goal #1 would be a major advance for science, goal #2 would be an even greater advance for humanity. We are, after all, talking about finding an effective and minimally toxic treatment for almost all cancers! For the next almost four decades, Pedersen and his coworkers struggled with this, among other problems.  
    A String of Discoveries  
    Along the way, Pedersen and his coworkers made at least a dozen major discoveries in the field of cancer metabolism. Without going into great detail (all of which is available in the standard medical literature), I will sketch the outlines of several below.  
    1970: Pedersen and his group discovered that cancers exhibiting the Warburg effect have a reduced respiration rate relative to their tissue of origin. However, this reduced respiration rate is not due to defective mitochondria but to a markedly reduced number of mitochondria (Schreiber et al. 1970).  
    1977: The Warburg effect mainly results from a less commonly used variant (called an isoform) of the enzyme hexokinase, which is markedly elevated in cancer and binds to the outer membrane of the mitochondria (Bustamante and Pedersen 1977).  
    1984: In cancer cells that exhibit the Warburg effect, there is a division of labor in producing the required energy. This central task is shared by two energy-producing factories: OxPhos and glycolysis. In some liver cancer cells, for example, about 60% of the energy comes from glycolysis and 40% from OxPhos in the mitochondria (Nakashima et al. 1984). This is a major point, as many people believe that cancer cells are fueled exclusively by glycolysis. However, malignant cells actually use both methods. Thus any agent that is postulated to cut the energy supply of a tumor must eradicate both energy-producing factories while leaving normal cells unharmed.  
    1988: The form of hexokinase (an enzyme) that is involved in the Warburg effect is hexokinase 2 (Hk-2; Nakashima et at. 1988). Other scientists later discovered that Hk-2 is bound to the outer mitochondrial membrane, where it renders cancer cells immortal.  
    2001: Now we come to the most important of all the discoveries in Pedersen’s lab. This was the finding, made by his colleague Ko, that in cancer cells a small molecule called 3-bromopyruvate (3BP) inhibits both glycolysis and OxPhos (Ko et at. 2001). This fulfills the second task that Pedersen set himself to accomplish in the 1960s.  
    Ko was born in South Korea. She completed her master’s degree in nutritional physiology at Iowa State University and graduate school in biochemistry/biophysics at Washington State University. In the 1990s she came to Johns Hopkins as a postdoctoral fellow. She and Pedersen have been working together since 1991 (Thomas 1992).  
    Asked by Pedersen to find a drug that would target both types of energy production, Ko thought of a substance that she had worked with as a graduate student. This was 3BP. In our conversation, Young referred to 3BP as a kind of “Trojan horse,” which tricks the cancer cell into thinking that it is receiving a useful nutrient, when in fact it is receiving a powerful cancer-killing molecule.  
    Given 3BP, as specially formulated by Ko, tumor cells are quickly destroyed, while normal cells are left unaffected. This is because, unlike tumor cells, normal cells do not have elevated levels of monocarboxylic acid transporters (MCTs). As Ko and Pedersen explained it, MCTs are the transporters that allow 3BP to get inside tumor cells. Once inside, 3BP quickly destroys both of the tumor cells’ power plants (glycolysis and OxPhos). The tumor cells die quickly via either apoptosis or necrosis (two common methods of cell death), attended by a rapid depletion of their energy.  
    2004: Ko and Pedersen, with half a dozen coauthors, published the first account showing that 3BP is able to completely destroy tumors in all animals tested, without causing noticeable toxicity. The tested animals lived out their normal lifespans without the cancerous tumors reappearing (Ko et al. 2004). Pedersen says that, to his knowledge, this was the first time in history that a small molecule was shown to have such remarkable cancer-curative effects.  
    2002: At around the same time, Ko and colleagues also participated in a study that showed that the intra-arterial delivery of 3BP formulated by Ko prevented cancer metastases (spreading) from the liver to the lungs (GeschwindKo, et al. 2002) and likely to other tissues as well. These are remarkable findings, unprecedented in cancer research. Prominent scientists have spent lifetimes in trying to discover agents with only a small fraction of the potential in this molecule. The significance of this finding cannot be overstated, since it is well known that most deaths from cancer result from its metastasizing to other organs, and not from the primary growth.  
    2012: Ko showed that 3BP can work in humans. In a recent paper, 3BP was tested successfully in a few people, with no obvious signs of toxicity. One young teenage patient from Europe, who had been sent home to die by his doctors, lived for another year after taking 3BP. He even was able to take a vacation to the US with his parents, where he participated in a clinical lecture at Johns Hopkins. His death was not due to the primary cancer, Ko told me, but to an infection (Ko et al. 2012).  
    The authors also showed that 3BP was capable of stimulating liver regeneration after first killing the primary liver tumor. This is believed to be the first time that a chemical agent was able to have such an organ-regenerating effect (Ko et al. 2012)  
    2013: In January, the Nobel laureate James D. Watson, PhD, codiscoverer of DNA’s “double helix” and the most renowned scientist in the world today, paid homage to 3BP and, by extension, to the work of Pedersen and Ko. He wrote:  


3-bromopyruvate, the powerful dual inhibitor of hexokinase as well as 

  oxidative phosphorylation, kills highly dangerous hepatocellular 

  carcinoma [liver cancer], cells more than 10 times faster than the 

 more resilient normal liver cells and so has the capacity to truly 

 cure, at least in rats, an otherwise highly incurable cancer. 

In his paper Watson referenced the 2004 Ko et al. manuscript.  
Pedersen’s career in biological chemistry essentially began in 1961 when he gave a seminar on the discoveries of James Watson and Francis Crick about the double-helical structure of DNA as one of his last requirements as an undergraduate chemistry major at the University of Tulsa. How ironic, then, that 50 years later Prof. Watson returned the compliment, and publicly paid homage to Pedersen and Ko’s work with 3BP. As Pedersen put it, “Perhaps it is fair to say that he or she who follows in the footsteps of other great scientists may one day have them following in their own footsteps.”  
2013: Prof. David M. Sabatini, a member of the Whitehead Institute of Biomedical Research (Cambridge, MA), and his colleagues recently confirmed Pedersen and Ko’s work with 3BP. Interestingly, but importantly, they made their confirmation without corresponding with either Pedersen or Ko before publishing their confirmatory paper (Birsoy 2013).   Sabatini and colleagues wrote:  


  Our results identify a potential biomarker for 3-BrPA [another 

 abbreviation for 3BP] sensitivity and provide proof of concept that 

  the selectivity of cancer-expressed transporters can be exploited for 

  delivering toxic molecules to tumors. (ibid.) 

Scientists would understand that the “toxic molecule” in question, 3BP, is only “toxic” in relation to cancer cells. Normal cells are spared as they have fewer transporters capable of moving 3BP into the cells.  
Readers will of course be happy to hear that such a promising new agent as 3BP has emerged from Johns Hopkins School of Medicine and has been confirmed by scientists at other institutions, such as the Whitehead Institute. 3BP is not only important in its own right but serves as “proof of principle” for the idea that one can manipulate metabolism to interfere with the growth of cancer. Pedersen believes in metabolic therapy and wrote the introduction to Thomas Seyfried’s provocative recent book, Cancer As A Metabolic Disease.  
On the other hand, there is a dark side to this story. First, after nearly a decade, 3BP remains unavailable to cancer patients. It is not even in formal clinical trials in the US. Perhaps even more outrageous still is that NIH study sections assigned to review two of Pedersen’s cancer-related renewal applications in recent years have rejected them several times. The few (2 or 3) peer reviewers assigned to look at each of their assigned applications have the power early on in meetings at the NIH (or some location nearby) to recommend its rejection. Once this is recommended, the application is thrown in the trash without a formal review; that is, a discussion involving not only the two or three assigned reviewers but the entire study section (15 to 30 scientists). This is simply an outrage, not only to the public at large but to those study section members who never had the opportunity to really read and discuss fully the applications.  
Perhaps an “angel” will appear to fund further necessary research into the remarkable activity of this substance. Or perhaps the issue will need to be slugged out in newspapers and websites, or in the halls of Congress, as has happened before in the history of cancer. However it happens, 3BP deserves further study and fair, honest, and thorough clinical trials so we can finally learn more about its potential as a simple, nontoxic or surely less toxic treatment for cancer.  
Finally, it should be noted that Dr. Pedersen sent a personal letter to President Obama about this matter on January 22, 2013. The president’s mother died of ovarian cancer at the early age of 53. Months later, Dr. Pedersen had still received no response from the president. If the federal government is seriously interested in ending the scourge of cancer it should pay attention to the exciting things that are happening in Baltimore. SOURCE: Cancer Decisions – July 2013 
Birsoy K, Wang T, Possemato R, et at. MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nat Genet. 2013; 45 (1): 104-108.  
Bustamante E, Pedersen PL. High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Nat! Acad Sci USA. 1977; 74 (9): 3735-3739.  
Geschwind J-FH, Ko YH, Torbenson MS, Magee C. Pedersen PL. Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. Cancer Res. 2002; 62(14): 3909-391 3.  
Ko YH, Pedersen PL, Geschwind JF. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett. 2001; 173 (1): 83-91.  
Ko YH, Smith BL, Wang V. et al. Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochem Biophys Res Commun. 2004; 324 (1): 269-275.  
Ko YH, Verhoeven HA, Lee MJ, et al. A translational study “case report” on the small molecule “energy blocker 3-bromopyruvate (3BP) as a potent anticancer agent; from bench side to bedside. Bioenerg Biomembr. 2012; 44 (1): 163-170.  
Nelson DL, Cox MM. Lehninger Principles of Biochemistry. 5th ed. New York: W.H. Freeman; 2008: 539.  
Martinez-Zaguilan R, Seftor EA, Seftor RE, et al. Acidic pH enhances the invasive behavior of human melanoma cells. Clin Exp Metastasis. 1996; 14 (2): 176-186.  
Nakashima RA, Paggi MG, Scott LJ, Pedersen PL. Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line. Cancer Res. 1988; 48 (4): 913-919.  
Schreiber JR, Balcavage WX, Morris HP, Pedersen PL. Enzymatic and spectral analysis of cytochrome oxidase in adult and fetal rat liver and Morris hepatoma 3924A. Cancer Res. 1970; 30 (10): 2497-2501.  
Thomas PJ, Ko YH, Pedersen PL. Altered protein folding may be the molecular basis of most cases of cystic fibrosis. FEBS Lett. 1992; 312 (1): 7-9.  
Watson J. Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol. 2013; 3 (1): 120144. 

About Chinese Medicine Treating Pancreatic Cancer

The bark of the Amur cork tree (Phellodendron amurense) has traveled a centuries-long road with the healing arts. Now it is being put through its paces by science in the fight against pancreatic cancer, with the potential to make inroads against several more. 

UT Health Science Center researcher A. Pratap Kumar was already exploring the cork tree extract’s promise in treating prostate cancer when his team found that deadly pancreatic cancers share some similar development pathways with prostate tumors. 

In a paper published in the journal Clinical Cancer Research, the researchers show that the extract blocks those pathways and inhibits the scarring that thwarts anti-cancer drugs. Dr. Jingjing Gong, currently pursuing post-doctoral studies at Yale University, conducted the study as a graduate student in Dr Kumar’s laboratory in the Department of Pharmacology. 

“Fibrosis is a process of uncontrolled scarring around the tumor gland,” said Dr. Kumar, a professor of urology in the School of Medicine at the Health Science Center and the study’s principal investigator. “Once you have fibrotic tissue, the drugs cannot get into the cancer.” 

Liver and kidney tumors also develop fibrosis and the resulting resistance to drugs, he said, and there are no drugs currently targeting that pathway in those cancers. 

The two pathways, or proteins, that contribute to fibrosis in those tumors also encourage Cox-2, an enzyme that causes inflammation, and the cork tree extract appears to suppress that as well, Dr. Kumar said. The complex interrelationship of these substances is “the million-dollar question,” he said, and solving that question is one of the next steps in his research. 

The potential of natural substances to treat and cure disease has great appeal, but the advantage of cork tree extract, available as a dietary supplement in capsule form, is that it already has been established as safe for use in patients. In a promising prostate cancer clinical study of 22 patients that Dr. Kumar helped spearhead, all the patients tolerated the treatment well, he said. Now researchers are analyzing the results, he said, and with more funding they plan to expand the study to a much larger group of patients. 

The dietary supplement is marketed as Nexrutine by Next Pharmaceuticals of Salinas, Calif., which provided a supply of the compound for the studies. Source: University of Texas Health Science Center at San Antonio – BIOScience Technology – March 3, 2014 


A Cancer Treatment in Your Medicine Cabinet?

WE believe that it might be possible to treat breast cancer — the leading cause of female cancer death — with a drug that can already be found in nearly every medicine cabinet in the world: Aspirin. 

In 2010, we published an observational study in The Journal of Clinical Oncology showing that women with breast cancer who took aspirin at least once a week for various reasons were 50 percent less likely to die of breast cancer. In 2012, British researchers, by combining results from clinical trials that looked at using aspirin to prevent heart disease, found that aspirin was also associated with a significantly lower risk of breast cancer death. 

And yet, until now, there have been no randomized trials (the gold standard of research) of aspirin use among women with breast cancer. 

It’s not hard to see why: Clinical trials are typically conducted on drugs developed by labs seeking huge profits. No one stands to make money off aspirin, which has been a generic drug since the Treaty of Versailles in 1919, and which costs less than $6 for a year’s supply. 

Thankfully, the first randomized clinical trial is now going on in Britain, made possible by funding from a nonprofit group, Cancer Research UK. But the British study is looking at four cancers, and won’t be done until 2025. If we in the United States had funding to do a similar trial, we could combine our data and get answers much faster. If the United States is to maintain its role as the global leader in biomedical research, it must fund its own trial of aspirin in breast cancer. 

Aspirin was originally derived from willow bark, which has been used as a painkiller since the time of Hippocrates. We don’t know exactly why it appears to work in fighting cancer. Aspirin reduces inflammation, and that may play a role in inhibiting the growth of tumors — perhaps by slowing the development of new blood vessels that nourish them, or by fighting old cells that keep growing when they should be dying off. It may also inhibit estrogen production, and we know that estrogen fuels the growth of most (but not all) breast cancers. 

If we could prove that aspirin was an effective treatment in a clinical trial, it would have major implications, especially for low-income patients. Modern hormonal treatments, used after surgery to try to prevent cancer from recurring, last a standard five years and can cost between $1,200 and $2,300 a year. But not everyone who needs them is actually taking them. Higher co-pays reduce the number of women who fill their prescriptions, according to a 2011 study. 

And that is just in the United States. Africa, Asia and Central and South America already account for more than 60 percent of the world’s cancer cases and about 70 percent of cancer deaths, according to the World Health Organization. The majority of the impact of the disease will be felt in those areas in the coming decades. Aspirin’s minimal cost would make it available in every country on earth, and for millions of women it could mean the difference between some treatment and none. 

It may also offer an alternative treatment to women who cannot tolerate widely used cancer drugs because of debilitating side effects. For example, Columbia University researchers found that half of breast cancer patients taking hormonal treatments (specifically, tamoxifen and aromatase inhibitors) were unable to take the drugs for the recommended five years. A survey by the advocacy group Breast Cancer Action found that the predominant reason was joint pain. The most serious possible side effects of taking aspirin are gastrointestinal bleeding and stroke, but they are rare. 

If aspirin truly works, we estimate that we could save 10,000 lives per year in the United States, and 75,000 in the developing world. 

It won’t take much to find out. A randomized study of approximately 3,000 women with Stage 2 and 3 breast cancer, lasting five years, would cost around $10 million. (We wouldn’t study women with Stage 1 disease because they have such a high survival rate already, nor women with Stage 4 cancer, because there is not enough evidence that aspirin would help when the disease has advanced that far.) 

Although $10 million is a relatively small amount for a large pharmaceutical company, it is too big for most federal grant mechanisms and nonprofit foundations. Our repeated attempts since 2010 to seek funding through federal grant mechanisms have been rejected. 

Yet even as government funding for research is slashed, the government is still willing to test new cancer drugs pushed by pharmaceutical companies, despite very high failure rates for those drugs. Federal grant review panels have no direct financial interest in the studies they approve for funding, but inevitably they are seduced by the more novel treatments — the scientific equivalent of the latest smartphone. And generic drugs, particularly ones as old and familiar as aspirin, just aren’t sexy. 

There’s a saying attributed to Hippocrates that extreme remedies are appropriate for extreme diseases. But in the case of breast cancer, the most simple of drugs may be the next great weapon. SOURCE: New York Times – May 19, 2014 


Optimal Particle Size for Anticancer Nanomedicines Discovered

The nanomedicine (red) with the optimal size shows the highest tumor tissue (blue) retention integrated over time, which is the collective outcome of deep tumor tissue penetration, efficient cancer cell internalization as well as slow tumor clearance. 

Nanomedicines consisting of nanoparticles for targeted drug delivery to specific tissues and cells offer new solutions for cancer diagnosis and therapy. Understanding the interdependency of physiochemical properties of nanomedicines, in correlation to their biological responses and functions, is crucial for their further development of as cancer-fighters. 

“To develop next generation nanomedicines with superior anti-cancer attributes, we must understand the correlation between their physicochemical properties — specifically, particle size — and their interactions with biological systems,” explains Jianjun Cheng, an associate professor of materials science and engineering at the University of Illinois at Urbana-Champaign.  

In a recent study, published in the Proceedings of the National Academy of Sciences, Cheng and his collaborators systematically evaluated the size-dependent biological profiles of three monodisperse drug-silica nanoconjugates at 20, 50 and 200 nm. 

“There has been a major push recently in the field to miniaturize nanoparticle size using novel chemistry and engineering design,” Cheng added. “While most current approved anti-cancer nanomedicines’ sizes range from 100-200 nm, recent studies showed that anti-cancer nanomedicines with smaller sizes — specifically of 50 nm or smaller — exhibited enhanced performance in vivo, such as greater tissue penetration and enhanced tumor inhibition.” 

“Over the last 2-3 decades, consensus has been reached that particle size plays a pivotal role in determining their biodistribution, tumor penetration, cellular internalization, clearance from blood plasma and tissues, as well as excretion from the body — all of which impact the overall therapeutic efficacy against cancers,” stated Li Tang, first author of this PNAS article. “Our studies show clear evidence that there is an optimal particle size for anti-cancer nanomedicines, resulting in the highest tumor retention. 

Among the three nanoconjugates investigated, the 50 nm particle size provided the optimal combination of deep tumor tissue penetration, efficient cancer cell internalization, as well as slow tumor clearance, exhibits the highest efficacy against both primary and metastatic tumors in vivo. 

To further develop insight into the size dependency of nanomedicines in tumor accumulation and retention, the researchers developed a mathematical model of the spatio-temporal distribution of nanoparticles within a spherically symmetric tumor. The results are extremely important to guide the future research in designing new nanomedicines for cancer treatment, Cheng noted. In addition, a new nanomedicine developed by the Illinois researchers — with precisely engineered size at the optimal size range — effectively inhibited a human breast cancer and prevented metastasis in animals, showing promise for the treatment of a variety of cancers in humans. 

Cheng, a Willett Faculty Scholar at Illinois, is affiliated with the departments of Bioengineering and of Chemistry, the Beckman Institute for Advanced Science and Technology, the Micro and Nanotechnology Laboratory, the Institute of Genomic Biology, the Frederick Seitz Materials Research Laboratory, and University of Illinois Cancer Center. 

Tang, who obtained his PhD degree from the University of Illinois with Jianjun Cheng, is currently a CRI Irvington postdoctoral fellow at the Massachusetts Institute of Technology. Collaborators and co-corresponding authors of the paper at Illinois include Timothy Fan, associate professor, veterinary clinical medicine; Andrew Ferguson, assistant professor, materials science and engineering; and William Helferich, professor, food science and human nutrition. SOURCE: Science Daily – University of Illinois College of Engineering – October 16, 2014 


Journal Reference: 

  1. L. Tang, X. Yang, Q. Yin, K. Cai, H. Wang, I. Chaudhury, C. Yao, Q. Zhou, M. Kwon, J. A. Hartman, I. T. Dobrucki, L. W. Dobrucki, L. B. Borst, S. Lezmi, W. G. Helferich, A. L. Ferguson, T. M. Fan, J. Cheng. Investigating the optimal size of anticancer nanomedicineProceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1411499111  
Answering Your Supplement Questions

Today I’d like to answer multiple questions sent to me regarding last week’s issue, in which I discussed the supplements that Mr. Mauldin and I are taking. By way of explanation, I didn’t include links to the actual products I discussed for the simple reason that I don’t want to give the impression that we’re recommending these products for financial reasons. 

I think that most people know it’s possible today for vendors to track where links come from. Some organizations give the linkers a cut of their revenues. does this through its affiliate program, but we’re not doing that. 

Personally, it always sort of irritates me when organizations appear to be hawking supplements because it makes me question their objectivity; so I didn’t include links. I’ve been convinced to do otherwise, however, in the explanations below. Let me clarify that we have no financial arrangement with anyone regarding these supplements. I write about them, and take them, based solely on the emerging science. Before you take anything yourself, you should always review the latest literature and speak with your physician. 

My interest is driven not just by a desire to be as healthy as possible, by the way; I’m also convinced that breakthroughs in biotech analytical tools are making it possible to find rather simple compounds that will have large impacts on health and demographics. Since demographic change is having an enormous impact on our economy and politics, we should be interested in anything with the potential to significantly increase healthspans and alter the makeup of the population. 

Since we’re talking about supplements, I should start with the most misunderstood: vitamin D. Everybody takes some. What has changed recently, however, is the consensus regarding optimal dosages. In fact, you can’t really say how much vitamin D you should take. It’s your 25-hydroxyvitamin D blood level that really matters. Different individuals will need very different doses of oral vitamin D to accomplish the target range recommended by the top researchers in this field, which is 40-60 ng/mL. 

I realize, by the way, that there are still some people in government science organizations that disagree with me. If you think about virtually any area of nutrition in which government has given guidelines over the past 50 years, there is a near 100 percent record of getting it wrong. Rather than go over the new research again, let me direct you to the University of California project dedicated to increasing understanding about D. It’s GrassrootsHealth, which you can access at this link. 

The thing I really like about this organization is that they offer a test for D levels, which is inexpensive compared to the cost of the average lab test. A superior solution is to find a doctor, like mine, who keeps up with the literature and prescribes a full blood workup regularly. I’m about two weeks late for my blood work now, by the way, but I’ve been overwhelmed of late. 

If you monitor the flood of new studies being published about vitamin D, it’s hard not to come to the conclusion that a program of societal supplementation would extend average healthspans enough to solve most of our healthcare budget problems. This assumes, of course, that people continued working and investing through the years of added health. If, however, they decided to use the extra years collecting retirement benefits, it would exacerbate the already enormous problem of unfunded entitlements for the aged, which is the main driver behind the debt crisis. 

Whenever anybody asks me about supplements, my standard answer is to take vitamin D3 before you worry about anything else. Dr. Michael Holick, who pioneered the new research on vitamin D, suggests that about 4,000 units a day will get most but not all healthy people up to about 40 ng/mL. My blood levels are typically closer to 60 ng/mL, but I live in South Florida and spend a little time in the sun most days. 

If you live farther north, however, the sun may not provide much help for much of the year. UVB is missing for most of the day in northern latitudes but is required for D synthesis. Sunshine has benefits other than vitamin synthesis, though. A Scottish study showed that people with greater but not extreme exposure to sunshine had statistically significantly lower blood pressure even when there was no ultraviolet B (UVB) present. This is apparently due to increased production of nitric oxide. 

When I got my D levels up where they should be about seven or eight years ago, the impact on my health was immediate and palpable. You can get D3 from here, but I take whatever brand my nutritional biologist wife happens to pick up at Walmart. I don’t worry about brands and have taken many. I know my serum blood levels are where I want them to be, so all the major brands seem to have worked. 

Last week, I concentrated on nicotinamide adenine dinucleotide plus (NAD+) precursors, based on the huge amount of research coming out now about this emerging area of science. Nicotinamide riboside (NR) is getting the most attention. Not only has NR been endorsed recently by several famous scientists, the first human studies showed that a single dose raises NAD+ levels. 

ChromaDex is the only supplier of nicotinamide riboside, a natural substance found in milk, as it owns the usage and manufacturing patents. It is brand-named Niagen, but ChromaDex does not sell the product directly. It’s available through and elsewhere. John and I take the High Performance Nutrition brand in the black and blue bottle. 

Incidentally, the ChromaDex scientific advisory board is chaired by Nobel laureate Roger Kornberg, a Professor at Stanford Medical School. His Nobel prize in Chemistry in 2006 was for research on the molecular basis of eukaryotic transcription, which my son and I discuss around the dinner table occasionally. When Kornberg accepted the role as chair of the SAB, he specifically cited his interest in NR due to his father’s research. 

Kornberg’s father was also a Nobel prize winner. A professor of biochemistry at Stanford, the late Arthur Kornberg won the prize for physiology or medicine in 1959 and pioneered nicotinamide riboside research while at the NIH. 

“Given my father’s noteworthy early research of nicotinamide riboside,” the younger Kornberg said, “I have been following ChromaDex’s progress on developing its Niagen nicotinamide riboside as well as the enormous amount of published research that speaks to the health benefits of NR.” 

The MIT recipe referenced here includes another ChromaDex product, pterostilbene, which occurs naturally in blueberry skin. John and I have been taking both of these molecules for several years now. It’s available under the trade-name pTeroPure from several sources, including Though others sell pterostilbene, I don’t trust other brands that don’t use the ChromaDex product. 

Another NAD+ precursor that we’ve both taken for several years is oxaloacetate. As is the case with NR, there is only one supplier which owns usage and manufacturing patents on the heat-stabilized version currently being used by universities researching efficacy in the treatment of neurodegenerative diseases. The company, of course, makes no medical claims as that would bring various government agencies down on its head like granite slabs dropped from helicopters. Free speech? Regardless, it’s trade-named benaGene, which you can also get through, but we get it from the manufacturer here. 

Oxaloacetate is a naturally occurring molecule that plays a critical role in the citric acid cycle and other cellular functions. It increases NAD+ through an entirely different mechanism of action than NR’s, so we take them both. It may not be necessary but it will be years before definitive information is generated. 

We also take acetyl-L-carnitine because it has been shown in animal studies to work synergistically with oxaloacetate. My wife and doctor have both recommended L-carnitine for a while, but it was this study showing complete restoration of long-term potentiation (LPT) in rats with cerebral ischemia, or stroke, that made me start taking it assiduously. 

Long-term potentiation (LPT) refers to the ability of brain synapses to increase signal transmission based on repeated activity. In other words, the study shows that oxaloacetate and L-carnitine completely restored the ability to learn in rats suffering from induced stroke. This seems like a very good sign to me, since LPT tends to decrease with age in humans. Given the option, I’d like to preserve the ability to learn as long as possible. Maybe, someday, I’ll even learn how to spell “rhythm” without a spell checker and remember my in-laws’ names. 

Anecdotally, a lot of people who use either NR or oxaloacetate report a lifting of mental “fogginess.” Dave Asprey, better known as the Bulletproof Executive, sells a coffee with oxaloacetate for that purpose. I don’t know, by the way, if his product is cost-effective. I haven’t looked that closely at his materials. Coffee on its own, by the way, is incredibly healthful for most people unless they let it interfere with sleep. I’ll spend one paragraph on coffee before returning to acetyl-L-carnitine and oxaloacetate. 

I’ve gone into the literature on the subject of coffee and caffeine innumerable times but it’s solid science. In previous articles, I’ve linked to this special issue of the Journal of Alzheimer’s Disease that categorized coffee as “disease-modifying” for AD. Editor Dr. Mark Smith, one of the world’s leading Alzheimer’s researchers before his accidental death a few years ago, was so enthusiastic about coffee as therapy that he made the issue free to download. In terms of cost-effectiveness, coffee has got to rank alongside vitamin D in efficacy. 

Returning to the subject of acetyl-L-carnitine, this naturally occurring substance breaks down in the blood to transport fatty acids into the mitochondria for conversion to adenosine triphosphate (ATP), which is the only form of energy our bodies can utilize. Acetyl-L-carnitine seems to be particularly important for those who exercise strenuously. 

It’s certainly possible that the same repair of long-term potentiation observed in rats will take place in humans. Anyway, acetyl-L-carnitine is generally considered beneficial on its own, as is oxaloacetate, so there doesn’t seem to be much downside to supplementation with both while the upside is potentially dramatic. 

Another supplement related to ATP energy production that we take is ubiquinol, a somewhat new and reduced (as opposed to oxidized) form of coenzyme Q10 (CoQ10) that appears to be more active. Ubiquinol is a critical part of the electron transport chain, transferring electrons in the process of synthesizing ATP. It’s also available through, as is acetyl-L-carnitine, though my wife buys them both at Walmart, I think. 

Then, of course, John and I are both using up the last of our anatabine citrate, which is no longer commercially available. I assume, however, that someone is hunting for another NF kappa B moderator. There’s an awful lot of unstudied alkaloids out there, and some very smart people know about the unprecedented data generated in the animal and human anatabine trials. Rock Creek Pharmaceuticals is miles ahead on the drug development path as they have permission to begin human trials for arthritis in the UK, but someone else may go after the supplement market. 

Hopefully, this answers all the questions I received. This isn’t a complete list of the supplements that John and I take, but I think it covers the most important and least known. Let me reiterate once more that we have no financial arrangements with the manufacturers of any of these products. 

My hope is you find the above discussion of supplements and the emerging science behind them compelling, and can begin your own research with the data I’ve provided. SOURCE: Transformational Technologies – February 20, 2015 

The Alternative Doctor’s 3 Pillars for Beating Cancer

The Survival Triangle 

I call my three pillars to beat cancer the “survival triangle.” If you’re serious about keeping (or getting) cancer out of your life, follow these steps to better health. They are simple, proven fighters that will make you a winner against this devastating disease. Taking a single one and making it part of your life will make a huge difference in your overall health. 

If you utilize all three, it will change your life. 

Now, before anything, let me say that traditional cancer treatment (surgery, chemotherapy, and radiation) does its part to help patients survive cancer. 

Unfortunately, they don’t address the root cause of cancer. They treat the tumors that result. They kill the cancer cells and a lot of healthy cells along the way. Conventional cancer modalities treat the disease…not the patient. 

Even oncologists who understand that toxins and inflammation are the underlying cause of millions of deaths globally from cancer every year aren’t addressing prevention techniques that will keep these patients from coming back with another cancer in a year or five years. 

Addressing the “Alternative Medicine Skeptics” 

If you don’t address the cause – the problems that start the cancer ball rolling – then you haven’t really beaten it…you’ve only managed to knock it unconscious for a while. 

You have to take control of your health. That requires you to understand how your body works and what it needs to do the best job for you that it can. 

If you don’t “believe” in alternative therapies, then you’re doing yourself a great disservice. Even if you fully expect traditional treatment to “cure you,” alternative methods can help you with the side effects you’re going to experience, keep your body stronger, and guard you against another episode of cancer in your future. 

Alternative choices can improve your quality of life and help you endure treatments such as radiation that leave the body (and immune system) ravaged and weak. The “war” against cancer leaves as much destruction as a real war. Much like the natural landscape and infrastructure is left annihilated in battle – so is your body after traditional treatment. 

Pillar #1 – DIET 

Cancer represents the biggest fight of your entire life.  You need to be as fit and healthy as you can be to meet the challenge. In order to handle the demands of exercise, to terminate infection and bacteria, to fight the effects of age, your body is going to need the right fuel. 

That is why diet is the first pillar of beating the root causes of cancer. 

Anyone (medical professional or otherwise) who tells you that diet does not affect your health or ability to fight disease is a liar. Period. 

Diet is everything. Even the World Health Organization (WHO) estimates that around 40% of cancers are caused by diet (I think the numbers are actually much higher). What you choose to put in your mouth may mean the difference between life and death. 

That isn’t dramatic, that is fact. 

Eating a diet filled with junk food, dyes, preservatives, excess sugar, caffeine, or other “empty” calories cannot and will not feed your body. If your body doesn’t get the right vitamins and minerals – it stops running. Just like a car without gas. 

There are many anti-cancer meal plans that I discuss in my books and on but there is no universal diet plan that will suit every person equally. Instead, dietary requirements must be assessed based on each individual’s specific needs. Remove any foods (no matter how much you love them) that cause stress to your immune system. 

My personal suggestion is to fill your diet with fresh, organic foods (where possible), salads, smoothies, and brightly colored produce. Remember that dairy, soy, grains, and even certain produce can be unknown stressors. Avoid white sugar, white flour, white rice, processed foods, dairy, and soy. 

Pillar #2 – Emotional Cleansing 

Negative emotion as a root cause of cancer is reality. There is far too much science to back this stance up, so keep an open mind. 

Stanford psychiatrist, Dr. David Spiegel, was a skeptic when he began his study on the influence of negativity on breast cancer patients. He was shocked to discover that at the ten-year survival checkup, those women who included therapy in their lives survived twice as long as those who did not. 

You read that right…there was a 50% better survival rate by purging negative emotion. 

Another Yale research study found that cancer spread faster in women who had “repressed personalities.” They defined the word “repressed” as having intense feelings of hopelessness and not having the ability to express anger, fear, or other negative emotions. 

In other words, they bottled it all up inside and it made them sicker, faster. 

Stress is known in the traditional and alternative communities as a major cause of inflammation. It is one thing everyone agrees on (though traditional medicine’s answer is another prescription). Inflammation has been discovered at the base of all known diseases. 

In other words, stress will kill you through cancer or heart attack or autoimmune disease…if you allow it to control your life. Balanced emotions equal a balanced physiological system. 


There are countless stressors in our modern world and many of them are foods, people or situations, and products we allow into our lives. We’ve talked about the first two. Let’s discuss the contamination most people never consider. 

Personal pollution is as dire as environmental pollution and we are surrounded by both at every turn. Pollutants are in our soil, water, and air and that means they are in our food supply. Those are harder to control (even organic foods are grown on the same planet we’ve corrupted with countless toxins). 

You can control what you put on your body, what you put in your body, and how you maintain the environments you live in most (your home and work space). 

If you haven’t heard about the chemical soup found in cosmetics, household goods, and everyday cleansers, I urge you to do some research on it right now. From heavy metals and arsenic to formaldehyde and parabens…products you buy every day at your local market are filled with endocrine disruptors, estrogen mimics, and outright poison to the cells in your body. 

One person I urge you to read is Dr. Sam Epstein, a professor of Occupational Health and Environmental Medicine at the University of Illinois School of Public Health. 

In his book, The Politics of Cancer, he states, “The NCI (National Cancer Institute) promised annual cancer mortality rates would be halved by the year 2000. The establishment now belatedly admits that cancer rates are increasing sharply. It discounts substantial evidence…the wide range of chemical and radioactive carcinogens permeating the environment, air, water, food, and the workplace. The establishment ignores, let alone investigates, carcinogenic contaminants in dietary fat, particularly pesticides, PCBs, and estrogen (with extensive and unregulated use as growth promoting animals food additives).” 

Big Business (food manufacturers, chemical producers, and even personal care manufacturers), and Big Pharma (drugs, drugs, drugs) don’t care about your health. They don’t care about “curing” anything at all because then…how would they make money? 

Every time you use cosmetics, shampoos, conditioners, antiperspirants, paints, household cleaning agents, laundry detergent, or any host of other products…you are playing Russian Roulette with your health. 

These deadly toxins don’t just pass through your system. No, that would be bad but your (healthy) immune system would be able to control most of the fallout. What makes many of these chemicals so dangerous is that they accumulate in your body, gradually building up (bit by bit) to levels that are toxic according to any agency. 

The True Causes of Cancer 

There are many things stressing your body each and every day. Junk nutrition, high levels of stress, and chemical contamination push these stressors past the brink of what your body can handle. SOURCE: The Truth About Cancer – Dr. Keith Scott-Mumby – July 11, 2015 


An Inexpensive Non Toxic and Effective Cancer Remedy

“I’ve been in cancer study for 20 years, and I’ve never seen anything like this, that just melts tumors away.” 

That was the view of Martin G Pomper, M.D., Ph.D., professor of radiology at Johns Hopkins School of Medicine. 

He said this back in 2004. 

What got him so excited, and why have we heard nothing about this remedy since? Read on to find out. 

The metabolic theory of cancer 

Initially produced in the 1940s, an off-the-shelf molecule called 3-bromopyruvate (3-BP) had been all but forgotten until it came to the attention of Young Hee Ko, Ph.D., a medical researcher at Johns Hopkins. 

It turned out to have special properties that made it ideal as an anti-cancer agent. 

But before we look at why she was interested in this chemical, we need to take a look at the lab she joined. 

It was headed by professor of biological chemistry and oncology, Peter L Pedersen, Ph.D. His research focused on cell energetics. Dr. Pedersen was a disciple of Nobel winning scientist Otto Warburg. 

According to Dr. Warburg, normal, healthy cells produce 95% of their energy aerobically (with oxygen) via the mitochondria, the cell’s “batteries.” But cancer cells are different. They produce up to 60% of their energy anaerobically (without oxygen) by breaking down glucose. 

This is a very inefficient, primitive way of generating energy, and – what’s worse — it produces lactic acid as a toxic byproduct. This is known as the Warburg Effect. It’s found in more than nine out of ten cancers. 

He believed a dysfunction in the mitochondria caused this switch in the way energy is produced and was the prime cause of cancer. 

Dr. Pedersen’s work focused on the mitochondria and documented the Warburg Effect in detail. He took his work further, noting the vastly reduced number of mitochondria in cancer cells and the structural abnormalities of the ones that remain. It seems like cancer cells have no option but to revert to a primitive form of generating energy. 

Most current cancer research focuses on genetic mutations. It’s become more or less medical doctrine that these mutations are the cause of cancer. In sharp contrast, the work of Dr. Pedersen and others is advancing a competing theory: The metabolic origin of cancer, which theorizes that cancer originates in mitochondrial damage, possibly caused by free radicals and toxicity. 

This damage disrupts the signaling that takes place between these energy centers and only then does the nucleus – the DNA — get disrupted. This leads to changes in gene expression and mutations. 

Dr. Pedersen and other like-minded scientists believe that gene mutations are an effect and not the underlying cause of cancer. Mitochondrial damage comes first. 

If true – and I think it is – the metabolic theory of cancer is the most important breakthrough in cancer research in decades.  

Meanwhile, enter Dr Ko, who has found a game-changing way to exploit this discovery. 

Trojan horse sneaks inside cancer cells 

When she joined Dr Pedersen, Dr. Ko threw herself into this research. Dr. Pedersen has a reputation as a workaholic, not taking a day off work in 22 years, but Dr. Ko surpassed his efforts, putting in 18 hour days and even sleeping in the lab. 

Fortunately, her dedication paid off. 

Because cancer cells produce a great deal of lactic acid, they need a way of expelling it, otherwise the cells would die of toxicity. To do this they create a lot of transporters to carry the acid, and pores to form an escape route for it. 

Dr. Ko wondered whether this difference between a normal cell and a cancer cell could be exploited. 

When working for her doctorate she studied 3-BP. The molecule mimics the chemical structure of lactic acid except that it’s very reactive. 

Her idea was that the cancer cell would mistake 3-BP for lactic acid. This would allow the substance to sneak into the cancer cell through the same pores that allow lactic acid to escape. It would act like a Trojan horse, creating havoc inside the mitochondria, shutting down both forms of energy production. 

Breathtaking, unbelievable results 

Initial laboratory testing of the molecule on human liver and breast cancer cell lines was compared with other chemotherapy agents such as cisplatin. The results were astonishing. 3-BP was far more powerful. The results were so surprising she found them hard to believe, so she repeated the test a hundred times. The results were the same. 

Testing on cancer cells cultured in a petri dish is one thing, the next big test would be in an animal model. 

Human liver cancer cells were seeded into 19 rats until the cancers grew 2-3 cm. These advanced cancers were then treated with 3-BP. 14 animals were used as controls and treated with saline. After 6 or 7 days all controls had to be euthanized. 

But in every 3-BP-treated animal the cancers were eradicated without toxicity within four weeks. Seven months later all remained alive, well and cancer free. 

This research was published in 2004. 

Subsequent research by the Johns Hopkins team and other labs has shown that 3-BP inhibits an enzyme called hexokinase II which promotes the use of glucose for cellular energy. This enzyme also helps to immortalize cancer cells. 

3-BP has demonstrated the following attributes: 

  • It is specific to cancer with little effect on normal cells 
  • It starts depleting energy reserves within minutes 
  • It doesn’t merely damage cancer cells, it kills them outright. Cancer cell membranes rupture and explode in rapid time 
  • After completing its mission, 3-BP destroys itself. It doesn’t remain on the loose to create any potential risks 
  • It exhibits little or no toxicity 

Why are we waiting? 

Dr. Pomper wasn’t the only one inspired by the animal study. Dr. David Hockenbery of the Fred Hutchinson Cancer Research Center in Seattle said the results were “quite dramatic and quite impressive.” 

And yet, twelve years on, there have been no human trials. 


The fact that 3-BP is a very cheap, common chemical that can’t be patented is certainly part of the explanation. The cost to patients from using 3-BP is estimated at 70 cents per day. 

Another reason is that a falling out took place between Dr. Ko and her employers, resulting in her dismissal and a long lawsuit. Although clinical trials have been held up, Dr. Ko is optimistic these will take place soon. We can only hope her optimism is justified. 

Better than any anti-cancer drug 

There have been anecdotal reports of remarkable cures in a small number of people, but the following case report is the only example published in a medical journal. 

Just 16 years old, Yvar had the fibrolamellar carcinoma form of liver cancer. There is no known treatment other than transplantation, but he did not fulfill the requirements. 

He was treated with the ‘gold standard’ liver drug sorafenib but benefits were short-lived. 

Treatment with 3-BP began in February, 2009. Yvar’s very poor appetite was quickly reversed. Enlarged spleen was drastically reduced. Indications of tumor death were evident. Regeneration of liver tissue was observed. By the summer he started to regain his physical strength. 

Unfortunately, in spite of regeneration of liver cells, liver functions were overloaded and couldn’t cope with the rapid destruction of tumor cells. The liver couldn’t detoxify dead cancer cell debris fast enough. Yvar died two years after first diagnosis, although he lived much longer than expected, and with an improved quality of life. 

The authors of the study noted that “the rate of tumor necrosis [death] due to 3-BP treatment seems to exceed all known cytostatic [anti-cancer] drugs.” 

Late-stage lung cancer cured with combination therapy 

In September 2014, doctors at the Cancer Treatment Institute of Columbia reported on a 66-year-old man with stage IV small cell lung cancer. The usual treatments had failed and his prognosis was poor. 

He was treated with 3-BP and the antibacterial and anti-cancer stem cell agent salinomycin. Four weeks later, chest CT scans revealed the total disappearance of the disease. 

Dr. Jason Williams, a member of the study team, said, “These two drugs are exceptional on their own, but it’s their combination that’s proving to be instrumental. Salinomycin and 3-BP work together to disable the cancer cell’s energy production and reduce the proportion of cancer stem cells. 

“Our initial work with human subjects has been more successful than we could have imagined.” 

Treatment with 3-BP is available 

3-BP is not approved by the FDA, and Dr. Ko does not recommend treatment from a ‘non-certified’ facility. To us old hands in alternative cancer treatment, this is no cause for alarm. 

Use of 3-BP in human patients is limited. While it should work on all tumors that exhibit the Warburg Effect (these will light up on PET scans), much is yet to be determined regarding dosage, timing and combination with other drugs or treatments. 

The concept has not been tested, but in theory 3-BP should work better with a ketogenic diet that greatly limits carbohydrates – a dietary strategy for starving cancer cells that can only metabolize carbohydrates. 

There are many unanswered questions, but nevertheless some German clinics offer this treatment. It is also available at the Dayspring Cancer Clinic in Scottsdale, Arizona, and at Cancer Immunotherapy Centers in Toronto, Canada. SOURCE: Cancer Defeated – August 10, 2016 



Vitamin C Effective in Targeting Cancer Stem Cells

Researchers measure the impact on cancer stem cell metabolism of 3 natural substances, 3 experimental pharmaceuticals and 1 clinical drug. 

Vitamin C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists in Salford, UK. 

The research, published in Oncotarget, is the first evidence that Vitamin C (ascorbic acid) can be used to target and kill cancer stem cells (CSCs), the cells responsible for fuelling fatal tumours. 

Dr Michael P. Lisanti, Professor of Translational Medicine at the University of Salford, said: “We have been looking at how to target cancer stem cells with a range of natural substances including silibinin (milk thistle) and CAPE, a honey-bee derivative, but by far the most exciting are the results with Vitamin C. 

“Vitamin C is cheap, natural, non-toxic and readily available so to have it as a potential weapon in the fight against cancer would be a significant step.” 

Cancer stem-like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth). 

The Salford team set out to assess the bioenergetics of cancer stem cells — the processes which allow the cells to live and thrive — with a view to disrupting their metabolism. 

Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drug stiripentol, 3 natural products — caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid — and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG. 

While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with Vitamin C, outperforming 2-DG by tenfold in terms of potency. 

Vitamin C has previously been shown to be effective as a non-toxic anti-cancer agent in studies by Nobel Prize winner Linus Pauling and was recently shown to reduce mortality by 25% on breast cancer patients in Japan. However, its effects on CSC activity have not been previously evaluated and in this context, it behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the “powerhouse” of the cell. 

Dr. Gloria Bonuccelli, lead author and another member of the Salford team added: “This is further evidence that Vitamin C and other non-toxic compounds may have a role to play in the fight against cancer. 

“Our results indicate it is a promising agent for clinical trials, and a as an add-on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis.” SOURCE: Science Daily – University of Salford – March 7, 2017 

Journal Reference: 

  1. Gloria Bonuccelli, Ernestina Marianna De Francesco, Rianne de Boer, Herbert B. Tanowitz, Michael P. LisantiNADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemnessOncotarget, 2015; DOI: 10.18632/oncotarget.15400
About Laetrile (aka) Amygdalin or Vitamin B17

Laetrile is the commercial name for a modified form of amygdalin, which is also known as bitter almonds. 

Chinese doctors allegedly used this substance, which is highly concentrated in the pits of apricots and other fruits, some 3,500 years ago for the treatment of tumors. Dioscorides of Anazarbos, 2000 years ago, was perhaps the first to document it. It was usually administered in the form of bitter almonds.  

Modern laetrile is usually derived from apricot kernels where it comprises about 2-3% of the kernel, a relatively large amount. It’s also found in the kernels of other fruits, such as plums, cherries, peaches, nectarines, and apples. All fruit seeds have a healthy form of organic cyanide in them, from apple seed to apricot seed, although laetrile treatments have been alleged to cause cyanide poisoning.  

The fruit kernels or seeds generally have other nutrients as well — some protein, unsaturated fatty acids, and various minerals. Although often called B17, laetrile is not found with other B vitamins in yeasts. Many plants do contain some laetrile, with the sprouting seeds, especially mung bean sprouts, containing the highest amount.  

The diet of primitive man and most fruit-eating animals was very rich in nitrilosides. They regularly ate the seeds (and kernels) of all fruits, since these seeds are rich in protein, polyunsaturated fats, and other nutrients. Seeds also contain as much as 2% or more nitriloside. When civilized humans eat less than the whole fruit — for example, by discarding the seed or kernel — they experience a specific and total deficiency not only in oils and proteins but also in minerals and such vitamins as B17 (nitriloside) because it is found only in the seed, not in the flesh of the fruit.  

Several other foods are naturally rich in nitriloside, including lima beans, succotash containing nitriloside-rich chick peas, plum jam, elderberry wine, bean sprouts, millet sprouts, sorghum molasses, wild berries, raspberries, macadamia nuts, and nitriloside-rich bamboo sprouts.  

Nitriloside was “rediscovered” in 1920 by a California physician, Ernest Krebs while experimenting with flavorings for bootleg whisky. His son, Dr. Ernest Krebs, Jr., purified it and coined the name ‘laetrile’ in 1952. Krebs’s studies showed that when a human or animal system ingests sufficient amounts of laetrile (or in its natural form, hydrocyanic acid), this substance becomes selectively toxic to cancer cells.  

In the early seventies, Dr. Harold Manner of the Biology Department at Loyola University, Chicago, conducted a study on a strain of mice using a combination of enzymes, Vitamin A, and laetrile. He reported in his book, Death of Cancer:  

“After 6-8 days, an ulceration appeared at the tumor site. Within the ulceration was a pus-like fluid. An examination of this fluid revealed dead malignant cells. The tumor gradually underwent complete regression in 75 of the experimental animals. This represented 89.3% of the total group.” (quoted in Moss, 1982).  

Laetrile needs to be taken with vitamin A and enzymes to be most effective.  

Pure laetrile has been illegal in the U.S. for decades and was pulled from the shelves in Britain.  

Challengers claim it is potentially toxic and leads to cyanide poisoning. As late as the end of the 1970s, between 50,000 and 100,000 cancer patients were ingesting close to 1 million grams per month. Only between two and three deaths were reported from accidental overdose. Considering these statistics, laetrile does not seem as toxic or dangerous as opponents make it out to be.  

Laetrile has been described as a parcel that contains poisons that are only released once the parcel is unwrapped. It has an effect on cancer cells because those cells secrete the enzyme beta-glucosidase that releases the cyanide, which then poisons the cancer cells. In contrast, normal cells have the enzyme rhodanase which effectively renders the cyanide molecule inactive. In the absence of cancer cells, the toxic cyanide is not released.  

Laetrile/amygdalin is not digested in the stomach by hydrochloric acid. Instead, it passes into the small intestine where it is acted on by enzymes that split it into various compounds, which are then absorbed.  

Laetrile can be separated by appropriate enzymes, in the presence of water, into glucose, benzaldehyde, and hydrocyanic acid. The last two substances are each, individually, a poison, but together they work synergistically and become more powerful when combined than when used separately.  

In the treatment of cancer, laetrile is used to reduce tumor size and further spread of the disease, as well as to alleviate the sometimes severe pain of the cancer condition.  

Laetrile does not make tumors grow smaller, so the question of tumor regression is sometimes brought up as evidence that laetrile is ineffective. Laetrilists argue that tumor size is not a good indicator of anticancer activity because a tumor does not just consist of malignant cells. Tumors also contain normal cells.  

When chemotherapy is used, all cells are attacked so it’s not unusual to see short-term tumor regression (because both malignant and normal cells are killed). Unfortunately, the long-term result of such treatment is for the tumor to become more aggressive due to the chance of increasing the ratio of malignant cells. In the case of laetrile, however, normal cells are not affected and so tumors do not decrease in size. Instead, they become benign.  

According to pathologist Gerald Dermer, “There is a marked discrepancy between ostensible tumor response and actual patient survival. In only about 32% of the clinical trials that reported significant tumor responses to new drugs was survival also prolonged.” In other words, tumor “response” or shrinkage may be largely irrelevant to controlling cancer, and the charge that laetrile doesn’t shrink tumors may be likewise irrelevant.  

Nearly all laetrile supporters advocate a diet of raw vegetables in conjunction with the therapy, partly because such a diet contains a large amount of dietary laetrile. Indeed, one of the things that makes the laetrile controversy so bizarre is that laetrile is a very common component of food.  

Between 1,200 and 2,500 plants contain laetrile. This includes most cereals and fruits and many vegetables. A diet that contains high quantities of the following will also be high in laetrile: chickpeas, bean sprouts, nuts, mung beans, blackberries, raspberries, and the seeds of apples, apricots, cherries, plums, and pears.  

Laetrile’s safety was demonstrated in an experiment with mice undertaken at a leading US cancer research institution (Memorial Sloan-Kettering Cancer Center). For thirty months, mice were injected daily with laetrile at a rate of 2 grams per kilogram of body weight (equivalent to giving a human a quarter of a pound a day). At the end of the period, the mice were healthier and exhibited greater wellbeing than the control group that did not get any laetrile.  

Refer to The Cancer Syndrome by Ralph Moss for more details.  

In addition, it should be noted that some young plants develop their own naturally occurring pesticides to provide some protection against insects and rodents. These pesticides are rich in nitrilosides, which are similar in chemical structure to laetrile. This presents the question that a diet high in young fresh plants such as alfalfa sprouts is like undergoing continuous non-toxic chemotherapy that kills pockets of cancer cells before they divide and grow.  

Laetrile authority Elson M. Haas M.D. says, “When used, laetrile is administered at 250-1,000 mg. (a gram is a thousand milligrams) daily. Higher amounts, up to 3 grams per day, have been used, but divided into several smaller dosages, each usually limited to 1 gram. If the source is whole apricot kernels, the quantity is usually about 10-20 kernels per day; 1-2 cups of fresh mung bean sprouts may provide an equivalent amount. If apricot kernels are blended or pulverized, it is suggested that they be consumed immediately.” SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

  • The cancer syndrome: With an afterword to the 1982 edition by Ralph W. Moss (1982)  
  • World Without Cancer: The Story of Vitamin B17 by G. Edward Griffin (2010)  
  • Death of Cancer by Harold Manner (1979)  
  • Alive and Well: One Doctors Experience With Nutrition in the Treatment of Cancer Patients by Philip E. Binzel Jr. (1994)  
  • Laetrile Control for Cancer by Glenn D. Kittler (1963)  
  • Politics, Science and Cancer: The Laetrile Phenomenon by Gerald Markle (1980)  
  • The Little Cyanide Cookbook; Delicious Recipes Rich in Vitamin B17 by June De Spain (2000)  
  • Vitamin B-17- Forbidden Weapon Against Cancer: The Fight For Laetrile by Michael L Culbert (1974)  


About Artemisinin (aka) Artemisia; Sweet Wormwood; Qinghaosu

Artemisinin, which is originally from Chinese folk medicine, is a type of chemical compound that comes from the common garden plant artemesia, or wormwood. It has been shown in studies to induce apoptosis (natural cell death) in human cancer cells. During an in vitro study, it successfully killed select cancer cells and slowed the growth of tumors in rats.  

In fact, Seattle scientists have shown that a compound extracted from the wormwood plant actually seeks out and destroys invaders such as breast cancer cells while leaving healthy cells unscathed. The substance is used extensively in European alternative cancer clinics 

Artemisinin is considered a safe, non-toxic, and inexpensive alternative for cancer patients. Chinese researchers said the key to its effect was a peroxide linkage (two oxygen atoms hooked together) within the herb’s active molecule, which makes this treatment very similar to oxygen therapy. Cancer cells thrive in an oxygen-free (anaerobic) environment and high levels of oxygen are therefore fatal to them.  

In laboratory experiments, the compound killed virtually all human breast cancer cells that had been exposed to the compound over a span of 16 hours. These studies were conducted by Dr. Henry Lai and his bioengineering research team at the University of Washington. Dr. Lai also stated that nearly all of the normal cells exposed to the compound remained alive.  

In a separate experiment, a dog with severe bone cancer known as osteosarcoma couldn’t walk across the room. The animal made a complete recovery within five days of receiving the treatment. X-rays showed the animal’s tumor “had basically disappeared,” says Lai. He added that the dog survived for at least two more years.  

Artemisinin reemerged as a therapy for malaria, for which it was once common, after a “secret recipe” for the treatment was discovered on a stone tablet in the tomb of a prince of the Han Dynasty during an archaeological dig in the 1970s. In fact, a purified form of the plant compound is now the drug of choice for treating malaria.  

Experiments into why artemisinin works as an anti-malaria agent led to its being tested as an anticancer drug. The key turned out to be a shared characteristic of the malaria parasite and dividing cancer cells: high iron concentrations.  

When artemisinin, or any of its derivatives, meets iron, a chemical reaction ensues. This prompts the creation of free radicals. In malaria, the free radicals attack and bind with cell membranes, breaking them apart and killing the single-cell parasite.  

Lai points out that cells need iron to replicate DNA when they divide. Because cancer is characterized by out-of-control cell division, cancer cells have much higher iron concentrations than do normal cells.  

“Not only does [the drug] appear to be effective, but it’s very selective,” Lai says. “It’s highly toxic to the cancer cells, but has a marginal impact on normal cells.”  

On the surface, cancer cells have more so-called transferrin receptors than healthy cells have.  

Transferrin receptors are cellular pathways that allow iron to enter. In the case of breast cancer, the cells have five to 15 times more transferrin receptors on their surface than normal breast cells, Lai says.  

The main strategy, according to Lai, is to pump up cancer cells with even more iron and then introduce artemisinin to kill them selectively. In his experiments, Lai subjected sets of both breast cancer cells and normal breast cells to two substances. The first was a compound known as holotransferrin, which binds with transferrin receptors to transport iron into cells and thus further increases the cells’ iron concentrations.  

The second was a water-soluble form of artemisinin. He also studied a combination of both compounds.  

Cells exposed to just one of the compounds showed no noticeable effect, Lai reported. But the response by cancer cells when hit with first holotransferrin and then artemisinin was dramatic, he says.  

After eight hours, three-fourths of the cancer cells were obliterated. After16 hours, nearly all the cancer cells were dead. Just as importantly, he says, the vast majority of normal breast cells did not die, showing the safety of the treatment.  

The normal breast cancer cells were also resistant to radiation utilized in the experiment, Lai adds. “So that means this approach might work for cancer resistant to conventional therapy.” One might expect even more aggressive cancers such as pancreatic and acute leukemia, known for rapid cell division and so much higher iron concentrations, to respond even better.  

Further animal testing followed by human trials is expected. In human trials, patients would likely be given iron supplements to raise the iron concentrations in their cancer cells.  

Even though human tests are years away, the treatment could revolutionize the way cancer, especially the aggressive, fast-growing kind, is approached.  

One study found elevated iron storage in 88% of breast cancer patients, so the application is logical. There’s also a wealth of research linking iron and cancer.  

Artemisinin is best taken on an empty stomach with some natural fat to enhance absorption. If iron is present from residual food, it may neutralize the peroxides. Milk has a minimal amount of iron, as do cottage cheese and yogurt—and all three have enough fat to enhance absorption. Artemisinin is also administered intravenously in some clinics. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

About Carnivora

Carnivora® was discovered and developed by Helmut G. Keller, MD, oncological investigator at Klinik Winnerhof in Bad Wiessee, Germany. It enhances the immune system response. Carnivora® is comprised of the pressed juices of Dionaea Muscipula, a concentrated extract of the Venusflytrap plant. It is supplied as drops for oral ingestion and inhalation, and as Carnivorain injections for intravenous and subcutaneous administration.  

Carnivora® capsules are now available in the U.S. as a food supplementCarnivora externally applied has helped with skin cancers and when taken in capsules. It may stop or reduce tumor growth. The active component of carnivora is plumbagin, a powerful immunological booster.  

Dr. Helmut Keller stated: “Carnivora®, a patented phytonutrient and extract of the Venus flytrap plant, Dionaea muscipula, has been used clinically for over 25 years.”  

Biologically active compounds in the extract are essential to healthy immune systems and to support healthy cardiovascular functions in the body. At higher doses, the extract has been shown to have immodulatorytumoricidal, antimicrobial, antiviral, antiparasitic and antibiotic properties.  

The pharmacology of Venus flytrap extract has been extensively studied and evaluated in both animal and human studies.  

Professor D.K. Todorov, MD, PhD, DSc, and Chief of Oncopharmacology at the National Oncological Center of Bulgaria performed clinical studies on Carnivora for over two decades. He has conducted cancer research at Heidelberg University in Heidelberg, Germany. His findings involving various cell lines show that cancer cells were destroyed within a matter of hours when exposed to Carnivora 

Dr. Todorov’s initial studies of sarcoma show the dramatic reduction of human sarcoma cells from 2500 to 880 over a 72-hour period. Additionally, Todorov found that 400 nanograms per milliliter (ng/ml) of Carnivora® had caused a diminution of 2200 multidrug resistant sarcoma cells to 1130 cells in just 72 hours.  

As a result of these in vitro findings, some doctors began to employ the protocol in vivo, treating patients with sarcoma tumors. Despite previous treatment with toxic therapies, some patients achieved remission.  

Professor Todorov performed a study on brain cancer by administering 200 ng/ml of Carnivora to human glioblastoma cells and achieved the destruction of 50% of these cells during a seven-day period.  

To study the effects of Carnivora against leukemia, Todorov used 200 ng/ml of Carnivora® to destroy human T-lymphoblastic leukemia cells. Thirty-one hundred of these cells were reduced to 1820 in 72 hours. He then took multi-drug resistant human leukemia cells and exposed them to 200 ng/ml of Carnivora to achieve remarkable results; within 72 hours, 2250 leukemic white blood cells were demolished to just 570 cells.  

Doctors have treated patients who suffer from chronic myeloid leukemia, as well as chronic lymphocytic leukemia with long-term Carnivora® therapy with great success. The key in this instance seems to be prolonged treatment. A majority of CML and CLL patients reported positive findings.  

And in the case of ovarian cancer, studies showed fifteen hundred ovarian cancer cells were dramatically reduced to 435 cells in a rat model in vivo when treated with 200 ng/ml of Carnivora® within forty-eight hours. Seventeen hundred eleven cells of human ovarian cancer were again dramatically reduced to a mere 359 cells upon exposure to 200 ng/ml of Carnivora® in just 48 hours. It was shown that despite this cancer’s chemotherapeutic resistance, Carnivora® had nearly destroyed this entire cell line. Carnivora® should not be used in conjunction with chemotherapy. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

  • German Cancer Therapies: Natural and Conventional Medicines That Offer Hope and Healing by Morton Walker (2003)  


About Controlled Amino Acid Treatment (CAAT)

Angelo P. John, a cancer theorist for more than 40 years, developed an extremely interesting and promising nutritional approach to help cancer patients. CAAT – Controlled Amino Acid Treatment — is a novel approach to cancer treatment. The treatment has been used since 1994 in very advanced-cancer patients combined with or without conventional treatment of radiation and/or chemotherapy. Angelo John develops these nutritional programs for cancer patients with the cooperation of the patient’s oncologist or with nutritionally oriented complementary and alternative physicians who work with cancer patients.  

CAAT is an amino acid and carbohydrate deprivation protocol that uses scientifically formulated amino acids. Based on the fact that the needs of normal cells and cancer cells are quite different, the diet of the cancer patient is manipulated to include a blend of amino acids (protein building blocks in the body). Cancer cells are literally starved to death.  

The program consists of:  

  • A strict diet  
  • A special amino acid blend—the exact blend depends to some extent on the type of cancer being treated  
  • Certain nutritional supplements, and the avoidance of others  

The treatment attacks cancer cells in four ways:  

  • Helps to prevent new blood vessel formation (angiogenesis), which is necessary for the growth of solid cancers.  
  • Interferes with the cancer cell’s ability to produce energy by blocking a process called glycolysis in cancer cells.  
  • Reduces the ability of the body to produce factors that stimulate growth of cancers.  
  • Interferes with the production of specific amino acids that are necessary for DNA replication in cancer cells.  

The diet is quite strict and is low in both carbohydrates and protein. Fat intake is moderate and involves specific fats. The amino acid blend reduces certain amino acids (such as glycine, valine, leucine, and isoleucine) and increases others, resulting in reduced production of the protein elastin, which is necessary for angiogenesis.  

In contrast to normal cells, which produce energy primarily through the use of oxygen, cancer cells produce energy by a process known as glycolysis because their mitochondria (energy producing structures in cells that utilize oxygen) are damaged and not capable of utilizing oxygen the way normal cells do. The theory is that the strict diet and the blend of amino acids attack the glycolysis process in cancer cells, thus helping to prevent the production of energy in cancer cells.  

Certain growth factors produced in the body, such as human growth hormone and insulin growth factor 1 (IGF1) tend to stimulate cancer growth. This program with its reduced calorie and protein diet tends to reduce the production of these growth factors. The growth of cancer cells requires certain amino acids (like glycine) and nutrients (like vitamin B6) for replication of the cancer cells’ DNA. The reduction of these nutrients in this CAAT protocol helps to inhibit DNA replication in cancer cells.  

A number of nutritional supplements are part of the program. These may include, but are not limited to:  

  • Vitamins A, C and D  
  • D-Limonene  
  • N-Acetylcysteine (NAC)  
  • Grape Seed Extract  
  • Lycopene and others  

On the other hand, most of the B vitamins, especially vitamin B6, are avoided because they enhance the glycolysis process or DNA replication.  

Regardless of the cancer type, all cancer cells survive through the same biochemical processes. CAAT interferes with these processes and causes the cancer cells to die, significantly increasing the patients’ chance of recovery. However, because each patient is unique, CAAT is designed for one’s specific needs, taking into account the patient profile and medical history. A personalized amino acid deprivation formula and food plan is designed for each patient’s individual requirements. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

  • Controlled Amino Acid Treatment (CAAT)-A Novel Nutritional Approach to Cancer Treatment by Michael B. Schachter, MD, CNS, FACAM  
About Baking Soda & Maple Syrup Protocol

An Italian doctor, Dr. Tullio Simoncini, was a trained surgeon, oncologist, endocrinologist, and diabetologist, with a University degree in philosophy. He became disturbed by what he viewed as the medical community’s blanket acceptance that cancer is ‘incurable’. He noted that the ‘genetics’ paradigm was 80 years old, and had never been proven—and the billions of dollars spent on chemotherapy and irradiation were doing nothing to improve survival rates.  

Dr. Simoncini contended that psoriasis, an incurable disease, is caused by a fungus, and this inspired him to think that perhaps cancer, another incurable disease, could also be caused by a fungus. There’s some evidence for his belief. Many works now document the presence of fungi in cancer patients’ tissues, especially in terminal patients.  

Of all the fungi that cause diseases in humans, proponents of this theory say that Candida is the sole agent responsible for tumors as well as other serious illnesses, such as septicemia. Candida is always present in the tissue of cancer patients. Fungi also cause tumors in the plant and insect kingdoms.  

Simoncini says most people, including doctors, underestimate the damage that opportunistic fungi can—and will—inflict.  

Fungi establish permanent, parasitic colonies. These colonies spread widely all through the body. They’re able to communicate with one another and to dominate host organisms.  

In most cases, neither patients nor doctors recognize the symptoms of fungal overgrowth. Most doctors will tell a patient the problem is local (for instance, bad digestion or a skin rash), rather than systemic (i.e. affecting the whole body).  

The immune system—when it detects a fungal enemy—tries to eradicate it before it can establish high-growth colonies. Unfortunately, a compromised immune system may be unable to do that. Fungi can bypass the epithelia and immune system and penetrate deeply into connective tissue, causing a biological reaction that tries to encapsulate the fungus—to form a container around it—the familiar bulbous tumor. However, the fungus colony not only expands aggressively in the original location, but pursues new habitats (metastasis).  

Fungi mutate into different shapes throughout their life cycle—shedding their cell wall to become nearly invisible under a microscope. This is one reason fungal infections can’t be detected in blood culture until the patient is nearly dead.  

At first, a patient is able to send mature cells to contain the fungi, now a differentiated tumor. But when fungus colonies become more powerful and the tissues become exhausted, they revert to ‘simpler’ forms that don’t require the higher-level functions of healthy differentiated cells such as lung cells or prostate cells.  

Advocates of this cancer theory say it’s always the same highly-adaptive Candida attacking different tissues—each time mutating and adapting itself to its new environment. Scientists think Aspergillus is a variation of Candida.  

The preferred treatment is to oxygenate the body, because cancer cells thrive in a low- or no-oxygen environment. A number of different cancer protocols attempt to oxygenate the body in different ways.  

Cancer cell growth is initiated by fermentation, triggered by the absence of oxygen at the cellular level.  

The body of cancer patients is characterized by an unhealthy acidity. In contrast, a healthy body is slightly alkaline. A high level of acidity prevents oxygen from accessing the tissues in need of it. Acidity also promotes a build-up of carbon dioxide in the tissues, leading to cell death. Many cancer experts besides Simoncini share the belief that a successful treatment plan should render the patient’s body more alkaline. But relatively few follow Dr. Simoncini’s method for doing so.  

Dr. Simoncini’s approach is to alkalinize the body with a solution of sodium bicarbonate — simple baking soda. The Simoncini protocol has earned a devoted following among people who advocate self-treatment, although it’s also used by some respected cancer doctors. There are countless testimonials to Dr. Simoncini’s protocol available online.  

According to the protocol’s advocates, sodium bicarbonate shocks cancer cells with massive amounts of oxygen which kills them like a poison, while leaving normal cells unharmed.  

It’s reported that sodium bicarbonate shrinks a two to four centimeter mass of cancer cells in only 4 to 5 days. Some patients are said to experience complete remission within 5 days.  

Sodium bicarbonate can be administered three ways: by mouth, with an aerosol, or intravenously.  

The more hard-to-reach cancers are treated by positioning catheters directly into the artery that nourishes the tumor, allowing high doses of sodium bicarbonate to enter the deepest recesses of the cancer mass. Today it’s even possible to reach cerebral masses without surgical intervention, in a completely painless way.  

Advocates say most tumors can be treated effectively with baking soda therapy—except for bone cancer, due to the lack of blood flow to the bones.  

A 2009 study showed sodium bicarbonate increases the pH of tumors, and reduce metastases and lymph node involvement (in breast cancer).  

The therapy is said to be extremely effective, painless, free of side effects, and very low risk. With catheterization, there’s a small risk of infection.  

It’s also inexpensive, at least in terms of the equipment and materials required. Catheters cost a bit more, but taking bicarbonate by mouth costs only pennies per day.  

Application via catheter, applied directly to the tumor, can be provided only by a mainstream doctor. Most won’t be willing to provide such a treatment. Also, full dosages cannot be administered to those with severe heart, kidney, and liver problems.  

Based on Simoncini’s theory it might seem logical that antifungal drugs would be effective anti-cancer drugs. Advocates say this is not the case. None of the antifungal drugs on the market share the effectiveness of sodium bicarbonate because they cannot penetrate tumor masses. In addition, fungi resist these drugs by quickly mutating into a different form. Finally, it’s alleged that the drugs weaken the immune system.  

Sodium bicarbonate, on the other hand, reportedly spreads in all directions and fungi cannot easily resist it—largely because it works so fast to disintegrate them that they can’t adapt to defend themselves.  

Therefore, advocates of this protocol recommend that a strong dosage should be used continuously, without interruption, for at least 7-8 days for the first treatment cycle.  

Advocates of this approach advise patients to add 1-2 teaspoons of aluminum-FREE baking soda and 1 teaspoon of pure maple syrup to 1 cup of water, and drink. Some sources say to heat it first. The ‘sugar’ acts as a delivery mechanism to hard-to-reach Candida cells. Mark Sircus, Ac OMD suggests doing this every 2 hours for no more than 2 weeks.  

This protocol is not recommended if the body is already alkaline. However, most cancer patients are acidic.  

Simoncini’s theory that fungus is the main cause of cancer is highly controversial, although many support the acid-alkaline theory of cancer causation and treatment. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

  • The Germ that Causes Cancer, by Doug A. Kaufmann  
  • Sodium Bicarbonate: Rich Man’s Poor Man’s Cancer Treatment, by Dr. Mark Sircus, Ac., O.M.D.  
  • Dr. Simoncini Web site:  
  • Robey IF, Baggett BK, Kirkpatrick ND, et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res. 2009;69:2260-2268  
About Graviola – Annona Reticulata

Graviola, which is the common name for Annona reticulata, is a fruit also known as soursop, guanabana, and custard apple. It comes from a tree common to South America and the Caribbean region. The leaves of the tree are commonly used in traditional medicine treatments to treat diarrhea and eliminate worms.  

Proponents claim it is more effective at killing colon cancer cells than common chemotherapeutic drugs because it seeks out and destroys prostate, lung, breast, colon, and pancreatic cancers while leaving healthy cells unharmed. It is also said to provide an immune system boost.  

The National Cancer Institute included graviola in a plant-screening program that showed its leaves and stems were effective in attacking and destroying malignant cells. Strangely, the results were never released to the public and remained part of an internal NCI report.  

There have been several promising cancer studies on graviola since 1976, when it was first introduced, but the tree’s extracts have yet to be tested on cancer patients. No double-blind clinical trials exist.  

Regardless, graviola has been shown to kill cancer cells in vitro (i.e., in laboratory cell cultures) in as many as 20 laboratory tests. A study conducted at Catholic University of South Korea demonstrated two chemicals extracted from graviola seeds were selective in cytotoxicity and comparable with Adriamycin (a common chemotherapy drug) for targeting and killing malignant breast and colon cancer cells.  

Perhaps the most significant result of this study and others is that Graviola was shown to selectively target only cancer cells, leaving normal, healthy cells untouched.  

By comparison, chemotherapy indiscriminately seeks and destroys all actively reproducing cells, including normal hair and stomach cells, which leads to the devastating side effects of hair-loss and severe nausea.  

Another study, published in the Journal of Natural Products, showed that graviola also outperforms Adriamycin in laboratory tests. One chemical found in graviola selectively killed colon cancer cells at 10,000 times the potency of Adriamycin.  

Research from Purdue University detailed the active components of the tree, which may be potent in inhibiting the growth of cancer cells. The Purdue studies found the active components to be effective against multi-drug-resistant (MDR) cancer cells, those cells that survive chemotherapy and cause cancer to return.  

Purdue researchers also found that leaves from the graviola tree killed cancer cells “among six human-cell lines” and were especially effective against prostate and pancreatic cancer cells.  

In a separate study, Purdue researchers showed that extracts from the graviola leaves are extremely effective in isolating and killing lung cancer cells.  

Graviola looks to be a promising alternative or supplement to mainstream treatments. Graviola and N-Tense (an anti-cancer formula featuring graviola and seven other rainforest herbs) are completely natural substances. No side effects have been reported except for possible mild gastrointestinal upset at high dosages (in excess of 5 grams) if taken on an empty stomach. See N-Tense, a patented substance that contains 50% graviolaSOURCE: Alternative Cancer Research Institute 

Further Reading & References  


About Poly-MVA

Poly-MVA is a uniquely formulated nutritional supplement designed to provide energy for compromised body systems. It is helpful in increasing energy, reducing fatigue, and enhancing overall health and well-being, and can be particularly helpful in addressing those symptoms in people who are receiving chemotherapy or radiation treatments for cancer. Many people have found Poly-MVA to be helpful in improving quality of life while undergoing a difficult treatment regimen.  

The Poly-MVA name comes from the combined terms Poly meaning “many, much, more than one”; M indicating “minerals”; V signifying “vitamins”; and A symbolizing “amino acids.” Poly-MVA is a proprietary blend of palladium, alpha-lipoic acid, vitamins, B1, B2 and B12, the amino acids formyl-methionine and acetyl cystiene, and trace amounts of molybdenum, rhodium, and ruthenium.  

According to the inventor of Poly-MVA, Merrill Garnett, DDS, PhD, cancer results from the failure of cells to mature. This in turn is caused by a problem of energetics in the cell’s metabolic processes. He has developed a chemical compound, palladium lipoic acid, that mimics an energy pathway present in normal cells but missing in cancer cells, and necessary to normal growth and health. As a new principle in the nutritional healing of most cancer types, Poly-MVA assists in correcting malfunctioning nucleic acids in the deoxyribonucleic acid (DNA) of genes.  

Dr. Garnett emphasizes that he chose to bind palladium to alpha lipoic acid (ALA) because this amino acid is both water and fat-soluble and able to travel everywhere in the human body, even through the blood-brain barrier, taking the palladium molecule with it.  

Dr. Garnett, whose Garnett McKeen Laboratory is located in Islip, New York, has produced a self-published book, First Pulse: A Personal Journey in Cancer Research. In it, the author-scientist offers a philosophical, highly technical, but interesting and anecdote-filled discussion of how he came to create his invention.  

Dr. Garnett searched for singular substances capable of binding together the various ingredients which make up Poly-MVA. He found the therapeutic component in the platinum-derived palladium mineral, poisonous in the hands of an allopathic dentist, but life saving for someone suffering from cancer. Yet palladium would be poisonous to cancer patients too, if it were not bound tightly to alpha lipoic acid and “sequestered” in the molecule as cobalt is sequestered in vitamin B12. Thus, palladium forms an organic metallo-vitamin-lipoic acid complex that joins with cobalt, a part of the vitamin B12 (cyanocobalamin) complex.  

Dr. Garnett created Poly-MVA based on knowledge unknown before he discovered what he calls the Second Genetic Code, regarded by some as a scientific breakthrough. (See the Garnett book for details about the highly complicated Second Genetic Code discovery.)  

Dr. Garnett discovered that palladium acts as an excellent catalyst for combining oxygen and hydrogen; the metal absorbs over 900 times its volume of hydrogen. His formula adapts palladium for strengthening the actions of other molecules, too; e.g., iron holds together the active parts of hemoglobin, and its holding action is reinforced in the presence of palladium. Other amino acids besides alpha lipoic acid make up some part of the Garnett formulation.  

“Patients I’ve observed taking Poly-MVA have thrived. Numbers of them are following its protocol now. In my opinion Dr. Garnett and Dr. Sanchez are providing a really well thought out, safe treatment for all types of malignancies. They should be commended,” affirms Dr. Stanley R. Olsztyn.  

Poly-MVA is manufactured as a liquid mostly for oral ingestion, although some physicians administer it intravenously (see the procedure reported below by David C. Korn, MD(H), DO, DDS, of Apache Junction, Arizona):  

“Since PC Spes [a popular prostate cancer treatment] was removed from the market by the FDA almost two years ago, I have substituted the administration of both intravenous and oral Poly-MVA for prostate cancer patients and found it to act effectively. After receiving the new product IV for six or eight weekly injections and simultaneously taking the liquid in water, my male patients find their prostate specific antigen (PSA) markers come down. They go on to take the oral liquid Poly-MVA alone for approximately ten or twelve weeks more. This protocol affords great results. Recently two of my patients dropped down to a PSA of one from much higher markers.  

“I believe that saturating the blood with Poly-MVA insures the nutrient’s elevated dosage swiftly penetrates into the prostate area, the brain, and other organ sites. The patient with blood saturation of Poly-MVA goes through a physiologic range of reactions illustrated by an elevation of body temperature. I administer the treatment for lymphoma, brain cancer, breast cancer, prostate cancer, and more.  

“Insulin potentiation therapy works well in conjunction with Poly-MVA. But for elderly men with bone pain from prostate metastases who are frail, my preference is to administer the Garnett treatment alone. It acts just like a ‘smart bomb’ for pain relief, requiring four or five hours of the IV Poly-MVA. Based on an educated estimate of tolerated IV liquid, my staff and I gradually increase the dosage to 15 or 20 cc.  

I additionally include vitamin E, CoEnzyme Q10, lycopene, saw palmetto, and other prostate-specific nutrients.  

“My impression is that the Poly-MVA molecule actually behaves like a mild chemotherapeutic agent, but it is safe and not destructive. Moreover, the Lipoic Acid Palladium Complex is highly effective for increasing cancer remission rates,” confirms Dr. Korn 

From the established therapeutic effects of its alpha lipoic acid/palladium complex, Poly-MVA provides at least 13 recognized anticancer benefits. The benefits are listed here from observations described by Dr. Merrill Garnett in a series of reports published on his animal studies conducted at the Garnett McKeen Laboratory. He has advised that the lipoic acid/palladium complex:  

  • Causes an indefinite variety of immune system responses, but with specific manifestations as indicated in the twelve additional attributes listed below. 
  • Seeks out and destroys cancer cells anywhere in the body by stealing their electromagnetic energy.  
  • Invigorates normal cells and helps to repair any damage the invasive cancer may have left behind.  
  • Reduces tumor size or causes the tumor to shrink.  
  • Produces an idiosyncratic set of effects, which include a pattern of lag-arrest-slow death of cancer cells from an inhibition of their energy metabolism.  
  • Prevents sterol biosynthesis, thereby preventing new cancer cell plasma membrane synthesis.  
  • Shows a very large fraction of sensitive cancer cells as a morphological feature.  
  • Promotes the growth of proliferating normal cells surrounding a core of central tumor necrosis consisting of dead cancer cells.  
  • Stimulates the infiltration of leukocytes for the removal of cancer cell debris.  
  • Has absolutely no toxic reaction and no adverse side effects.  
  • Accomplishes its therapeutic benefits in both animals and humans.  
  • Works against cancer of many types not only as an orally-administered liquid but also perhaps even more effectively as an intravenous injection.  
  • Reduces the incidence of cachexia( (the “wasting away” characteristic of cancer patients) with a potential for increased body weight  

The late oncologist Dr. Rudy Falk’s original anticancer usage protocol strictly for cancer prevention consisted of only 1/2 teaspoonful a day of Poly-MVA. For therapy, a new and updated Poly-MVA protocol is now enthusiastically recommended by the Advanced Medicine and Research Center (AMARC) of Chula Vista, California. The protocol is presented in a publication written by Albert Sanchez, Sr., PhD, EdS, and made available by AMARC.  

From the website:  

“As noted in the letters below, oncologists & physicians are reporting the benefits of Poly MVA when used in conjunction with conventional cancer treatments or as part of other protocol therapies. These physicians are reporting complete remission of aggressive, stage IV cancers that have metastasized as well as continued positive responses in other patients with previously chemo-resistant cancers. Other noted benefits have been significantly improved quality of life and a substantial reduction in the number and severity of side effects from chemo and radiation therapies.”  

The Cancer Screening & Treatment Center of Nevada, for example, reported a 70% Positive Response Rate in Stage IV Cancer Patients At the same website, the Four Corners Approach is described that apparently has proved very effective for cancer survivors, including those who had been deemed late-stage: SOURCE: Alternative Cancer Research Institute 

  • Destroy anaerobic (cancer) cells  
  • Improve the immune system  
  • Detoxify the body  
  • Reverse acidosis (low body pH)  

Further Reading & References  

  • Poly-MVA: Palladium Lipoic Complex, (Note: For informational purposes only; not an endorsement)  
  • Townsend Letter for Doctors and Patients, Feb-March, 2003: Cancer remission rates increase from use of the safe and effective lipoic acid palladium complex poly-MVA – Medical Journalist Report of Innovative Biologics.”  
  • Diseases, 2nd Edition. (Springhouse, Pennsylvania: Springhouse Corporation, 1997), pp. 362-364.  
  • Sanchez, A. What You Must Know to Overcome Cancer. (Chula Vista, California: ARMARC, 2001), pp. 51-54.  
  • Garnett McKeen Laboratories: Nucleotide reductase. U.S. Patent No. 557,637 (October 31, 1995).  
  • Diamond, W.J.; Cowden, W.L.; Goldberg, B. An Alternative Medicine Definitive Guide to Cancer. (Tiburon, California: Future Medicine Publishing, Inc., 1997).  
  • Garnett, M. First Pulse: A Personal Journey in Cancer Research, Second Edition. (New York, New York: First Pulse Projects, Inc., 2001).  
  • Poly-MVA Cancer Breakthrough: Palladium Lipoic Complex. (Chula Vista, California: AMARC, 2001), p. 4.  


About the Budwig Protocol - Flaxseed Oil & Cottage Cheese (FOCC)

Dr. Maud Tresillian Fere was a conventional medical doctor in all ways except for her view of cancer treatment. She strongly believed in the power of dietetic control combined with simple supplementary medication. In fact, using these methods was how she claimed to have healed her own cancer of the bowel.  

Dr. Tresillian Fere stresses the importance of understanding exactly what goes into the food and drink you consume on a daily basis. She shares vital information on water, sources of the best carbohydrates and proteins, and what she calls “cleansing foods,” which are raw vegetables and fruits. In addition, she held that excessive sodium, along with breaking the Laws of Good Health as she describes them, were the most common cause of cancer development.  

She also touts health habits such as getting plenty of fresh air, having enough sleep and relaxation, and maintaining a generally cheerful attitude.  

Dr. Tressillian Fere’s cancer treatment also included a constant regimen of medicine made up of treatments such as iodine, stock vinegar, and acidulated water. She points out that these things are natural chemicals as opposed to drugs.  

Further Reading & References  

  • Does Diet Cure Cancer? by Maud Tresillian Fere  

Dr. Johanna Budwig/Flaxseed Oil & Cottage Cheese (FOCC)  

Dr. Johanna Budwig, a German physician and seven-time alternative Nobel Prize nominee, created what is now called the “Budwig Protocol” as a way to cure cancer. It mainly consists of a three-month flax oil-quark program, which is a combination diet of whole flaxseeds, flaxseed oil, and low-fat organic cottage cheese (known in Europe as “quark”).  

The Budwig diet includes a long list of other recommended foods such as herbs, nuts, cocoa, and tea. She also provided a list of foods to stay away from, which include hydrogenated oils, hard-shell seafood, white breads, and soy products.  

The Budwig program replenishes cells that are devoid of essential fats and oils, thereby allowing them to function once again. In turn, this leads to healing and recovery from a number of degenerative diseases including cancer.  

Dr. Budwig held that cancer was caused by one of four things: a weak immune system, toxins, an improper diet, or oxygen deprivation (or a combination of any of these things).  

Dr. Budwig states in her book, Flax Oil As a True Aid Against Arthritis, Heart Infarction, Cancer, and Other Diseases:  

“I often take very sick cancer patients away from hospital where they are said to have only a few days left to live, or perhaps only a few hours. This is mostly accompanied by very good results…in the hospital it was said that they could no longer urinate or produce bowel movements. They suffered from dry coughing without being able to bring up any mucous. Everything was blocked. It greatly encourages them when suddenly the …fats with their wealth of electrons, start reactivating the vital functions and the patient immediately begins to feel better.”  

After three decades of research Dr. Budwig, a seven-time Nobel Prize nominee, found that the blood of seriously ill cancer patients was always, without exception, deficient in certain important essential ingredients such as phosphatides and lipoproteins. The blood of a healthy person always contains sufficient quantities of these essential ingredients. However, without these natural ingredients cancer cells grow wild and out of control.  

In the course of her research, blood analysis showed a strange greenish-yellow substance in place of the healthy red oxygen carrying hemoglobin that belongs there. This explained why cancer patients weaken and become anemic. This startling discovery led Dr. Budwig to test her theory. She found that when these natural ingredients were replenished over approximately a three-month period, tumors gradually receded. The strange greenish elements in the blood were replaced with healthy red blood cells as the phosphatides and lipoproteins almost miraculously reappeared. Weakness and anemia disappeared and life energy was restored. Symptoms of cancer, liver dysfunction and diabetes were completely alleviated.  

Dr. Budwig then discovered an all-natural way for people to replace those essential ingredients in their bodies. Eating organic flaxseed oil & cottage cheese together made for an effective natural remedy since each triggers the release of the healing properties of the other.  

In the mid 1950′s, Dr. Budwig began her long and meticulous research on the importance of essential fatty acids (linoleic and linolenic) in the diet.  

Her subsequent discoveries and announcements sparked mixed reactions. While the general public was eager for this information, German manufacturers of commercial dietary fats (margarine, hard shortening, vegetable oils) went to extremes to prevent her from publishing her findings.  

Dr. Budwig preached against the use of these fats, which she called “pseudo” fats. In order to extend the shelf life of their products, manufacturers use chemical processes that render their food products harmful to the body. These harmful fats go by a number of names, including “hydrogenated,” “partially hydrogenated,” and even “polyunsaturated.”  

More than 50 years later, it has now become widely accepted that the hydrogenated “trans fats” made by these manufactures are profoundly harmful. There is no question that Dr. Budwig was right about this subject, yet her other findings, especially those concerning the benefit of the flaxseed oil/cottage cheese mixture, have not gained acceptance despite the testimony of many patients who controlled or reversed their cancers using the Budwig Protocol.  

The chemical processing of fats destroys the vital electron cloud within the fat. Once the electrons have been removed, these fats can no longer bind with oxygen, and they actually become a harmful substance deposited within the body. The heart, for instance, rejects these fats and they end up as inorganic fatty deposits on the heart muscle itself.  

Chemically processed fats are not water-soluble when bound to protein. They end up blocking circulation, damage heart action, inhibit cell renewal, and impede the free flow of blood and lymph fluids. The bioelectrical action in these areas slows down and may become completely paralyzed. The entire organism shows a measurable loss of electrical energy which is replenished only by adding active lipids to the diet. These nutritional fats are vital.  

Science has proven that fats play an important role in the functioning of the entire body. Fats (lipids) are vital for all growth processing, renewal of cells, brain and nerve functions, sensory organs (eyes and ears), and for the body’s adjustment to heat, cold, and quick temperature changes. Our energy resources are based on lipid metabolism. To function efficiently, cells require true polyunsaturated, live electron-rich lipids, present in abundance in raw flaxseed oil. True polyunsaturated fats greedily absorb proteins and oxygen and pump them through the system.  

Lipids are only water-soluble and free-flowing when bound to protein; thus the importance of protein-rich cottage cheese. When high quality, electron-rich fats are combined with proteins, the electrons are protected until the body requires energy. This energy source is then fully and immediately available to the body on demand, as nature intended.  

Dr. Roehm, an oncologist, stated in the July 1990 issue of the Townsend Letter for Doctors:  

“What Dr. Johanna Budwig has demonstrated to my initial disbelief but lately, to my complete satisfaction in my practice is: CANCER IS EASILY CURABLE, the treatment is dietary/lifestyle, the response is immediate; the cancer cell is weak and vulnerable; the precise biochemical breakdown point was identified by her in 1951 and is specifically correctable.”  

Dr. Roehm further claimed:  

“… this diet is far and away the most successful anti-cancer diet in the world.”  

General Rules for the Budwig Diet:  

  • The patient has no nourishment on Day 1 other than 250 ml (8.5 oz) of flax oil with honey plus freshly squeezed fruit juices (no sugar added!). In the case of a very ill person, champagne may be added on the first day in place of juice and is taken with the flax oil and honey. Champagne is easily absorbable and has a serious purpose here.  
  • Sugar is absolutely forbidden. Grape juice may be added to sweeten any other freshly squeezed juices.  
  • Other forbidden foods are:  
  • All animal fats.  
  • All Salad Oils (this includes commercial mayonnaise)  
  • All Meats (chemicals & hormones)  
  • Butter  
  • Margarine  
  • Preserved Meats (the preservatives block metabolism even of flax oil)  
  • Freshly squeezed vegetable (and certain fruit) juices are fine – carrot, celery, apple, and red beet.  
  • Three times daily a warm tea is essential – peppermint, rose hips or grape tea – all sweetened as desired with honey. One cup of black tea before noon is fine.  

Daily Plan:  

  • Before breakfast – a glass of acidophilus milk or sauerkraut juice is taken.  
  • Breakfast – Muesli (regular cereal) is topped with 2 tablespoons (30 ml) of flax oil and honey and fresh fruit according to season – berries, cherries, apricots, peaches, grated apple. Vary the flavor from day to day. Use any nuts except peanuts. Herbal teas as desired or black tea. A 4 oz (120 g) serving of “The Spread” (directions below). This is fine to eat straight like a custard, or add it to other foods taken in the day as you will see.  
  • Morning snack (10am) – A glass of fresh carrot juice, apple, celery, or beet-apple juice is taken.  
  • Lunch – Raw salad with yoghurt-flax oil mayonnaise (directions below).  
  • In addition to green salads, use grated turnips, carrots, kohlrabi, radishes, sauerkraut, or cauliflower. A fine powder of horseradish, chives, or parsley may be added for flavor.  
  • Cooked meal course – steamed vegetables, potatoes, or such grains as rice, buckwheat, or millet may be served. To these add either “The Spread” (see below) or “The Mayo” (see below) – for flavor and to increase your intake of flax oil. Also, mix “The Spread” with potatoes for an especially hearty meal. Add caraway, chives, parsley, or other herbs.  
  • Dessert – Mix fresh fruit other than those used for breakfast with “The Spread,” this time (instead of honey), flavor using cream of lemon, vanilla, or berries.  
  • Afternoon snack (4pm) – a small glass of natural wine (no preservatives) or champagne or fresh fruit juice with 1-2 tablespoons of honey-coated flax seeds.  
  • Dinner – have this early, at 6pm. Make a hot meal using buckwheat, oat, or soy cakes. Grits from buckwheat are the very best and can be placed in a vegetable soup, or in a more solid form of cakes with herbal sauce. Sweet sauces & soups can always be given more healing energy by adding “The Spread.” Only honey or grape juice can be used for sweeteners. NO white sugar (or brown!) Only freshly squeezed juices and NOT reconstituted juices (preservative danger) may be used. These must be completely natural.  

How to prepare The Spread:  

  • Place 250 ml (8.5 oz) flaxseed oil into a mixer bowl and add one pound (450 g) of 1% cottage cheese (i.e. low fat Quark) and add 4 tablespoons (60 ml) of Honey. Turn on the mixer and add just enough low fat milk or water to get the contents of the bowl to blend in together. In 5 minutes, a preparation of custard consistency results that has NO taste of the oil (and no oily ‘ring’ should be seen when you rinse out the bowl).  
  • Alternatively, you can use yogurt instead of cottage cheese in proportions of 1 oz (30 g) of yogurt to 1 tablespoon (15 ml) each of flaxseed oil and of honey and blend as above. Note: When flaxseed oil is blended like this, it does not cause diarrhea even when given in large amounts. It reacts chemically with the (sulphur) proteins of the cottage cheese, yoghurt, etc.  

How to prepare the Mayonnaise:  

  • Mix together 2 tablespoons (30 ml) flaxseed Oil, 2 tablespoons (30 ml) milk, and 2 tablespoons (30 ml) yogurt.  
  • Then add 2 tablespoons (30 ml) of lemon juice (or apple cider vinegar) and add 1 teaspoon (2.5g) of mustard plus some herbs such as marjoram or dill.  
  • Next, add 2 or 3 slices of health food store pickles (no preservatives – read the label) and a pinch of herbal salts.  

You will have to remain on this diet for a good five years, at which time your tumor may have disappeared. Persons who break the rules of this diet, Dr. Budwig reports, (i.e., eating preserved meats, candy, etc) will sometimes grow rapidly worse and cannot be saved after they come back from their spree.  

In 1967, Dr. Budwig broadcast the following statement during an interview over the South German Radio Network, describing her incoming patients with failed operations and x-ray therapy:  

“Even in these cases it is possible to restore health in a few months at most, I would truly say 90% of the time.  

“This has never been contradicted, but this knowledge has been a long time reaching this side of the ocean, hasn’t it? Cancer treatment can be very simple and very successful once you know how. The cancer interests don’t want you to know this. May those of you who have suffered from this disease (and I include your family and friends in this) forgive the miscreants who have kept this simple information from reaching you for so long.”  

It is believed Dr. Budwig was referring to people above who had NOT previously been treated with radiation or chemotherapy. Flaxseed oil is readily denatured by oxygen, heat, and light. That’s why it is used in paint. Rancid oil is bad for health, so the flax oil MUST be carefully produced, packed under nitrogen in lightproof containers, refrigerated until used, used as fresh as possible, and promptly stabilized with protein once the container is opened.  

Flaxseeds may also be used. Seeds need only be cracked in a food blender, or they may be ground in a coffee grinder. One needs three times the amount of seeds to get the oil equivalent. The seeds are also high in soluble fiber, so blending with liquid tends to produce ever-hardening “jellies.” Fresh-cracked seed sprinkled on muesli & eaten promptly tastes great.  

At one time, Dr. Budwig served as the Central Government’s Senior Expert for fats and pharmaceutical drugs in Germany, therefore giving her a reputation during her life as one of the world’s leading authorities on fats and oils. She held that the trans fats used in most deep-fried and processed foods actually work to suffocate cells. By depriving those cells of life-giving oxygen, the result is chronic or terminal disease.  

Dr. Budwig held very strongly that her treatment regime could successfully treat cancer. Her views on trans fats, once controversial, are now accepted everywhere. She had 50 years of successes spanning over 2,400 people with cancer and other diseases to back up her claim.  

There are variations of the above protocol which are reportedly effective, and some leading alternative cancer clinics and doctors will encourage their patients to use the flaxseed oil/cottage cheese mixture along with other therapies.  

Bill Henderson, perhaps North America’s leading advocate of the Budwig Protocol, offers this recipe:  

“One-third of a cup of flaxseed oil mixed with two-thirds of a cup of cottage cheese. Add berries, almonds and walnuts and a little stevia [optional] in the blender. Add a little fresh water. Adjust to taste. Blend on the ‘liquefy’ setting. Eat it as soon as it’s blended. Order flaxseed oil from Barleans at 800-445-3529 or . When you’ve gotten rid of your cancer you can scale back to a maintenance dose, which cuts the amount of flaxseed oil and cottage cheese in half.” He adds that “Stirring isn’t good enough. To mix it properly, you have to blend it. . .You may have heard that dairy products are bad for cancer patients, and I would agree with that. But when you mix cottage cheese with flax oil, it loses its dairy property. Dozens of people I know who are lactose-intolerant eat the Budwig protocol every day without any problems whatsoever.” SOURCE: Alternative Cancer Research Institute 

Henderson’s Special Report, How to Cure Almost Any Cancer at Home for $5.15 a Day, is available at www.cancerdefeatedpublications. com .  

Further Reading & References  

  • Flax Oil As a True Aid Against Arthritis, Heart Infarction, Cancer, and Other Diseases by Dr. Johanna Budwig  
  • Cancer: The Problem and the Solution by Dr. Johanna Budwig  
  • The Oil Protein Diet Cookbook by Dr. Johanna Budwig  
  • Budwig Center:  
  • Health and Well-Being, featuring Dr. Johanna Budwig  
  • Roehm, Townsend Letter for Doctors, July 1990  
  • “Promotion and Prevention of Tumour Growth Effects of Endotoxin, Inflamation, and Dietary Lipids”, by Raymond Kearney, Ph.D, Department of Infectious Diseases, The University of Sydney, Sydney, N.S.W. 2006 Australia. International Clinical Nutrition Review, October, 1987 Vol. 7, No. 4.  
About the Dr. Hulda Clark Treatment

Dr. Hulda Clark Ph.D.,N.D., was an independent research scientist specializing in biology, biophysics and cell physiology. In 1979, Dr. Clark left government research to begin private consulting full-time and in 1985 developed a radio electronic technique for scanning the human body, the Syncrometer, which tests for viruses, bacteria, fungi, parasites, solvents and toxins. This gave her clues to the cause of cancer, HIV and other diseases. Her health books are best sellers—at one time they were in the top 3% of books sold on  

Her theories are based on the simple idea that the human body heals itself if kept in good condition. No matter how many symptoms a person has, she attributes them to only two causes of health problems:  

  • Pollutants (toxins which make it difficult for organs to do their work—especially isopropyl alcohol)  
  • Parasites (protozoa, amoeba, worms that utilize our food and leave us with their wastes).  
  • Parasites – electronic and herbal treatment  
  • Pollution – avoidance  

Her solution to good health is as follows: Her strategy to return to health is:  

  • Kill all parasites, bacteria, viruses, and fungi.  
  • Remove toxic molds, metals and chemicals from food and body products.  
  • Clear and wash away gallstones, secretions and debris already formed that hinder healing.  
  • Use herbs and special food factors to hasten healing, being careful to use only unpolluted products.  

Hulda Clark is more concerned with the food that’s free from parasites, bacteria and chemicals rather than with the style of nutrition or lack thereof in dealing with cancer. Her approach is different from those who specialize in cancer-controlling foods and nutrition.  

Flatworms, roundworms, protozoa, bacteria, and viruses are killed using a combination of an electronic device called a ‘zapper’ and an herbal parasite killing program. Dr. Clark has found that this can benefit almost every illness. The zapper is a handheld battery operated (9V) frequency generator that uses a positively offset square wave to electrocute parasites. Its effectiveness is believed to be because it regenerates the white blood cells by building a positive magnetic field in the body. It is a recognized medical device, but should not be used by people with pacemakers or by pregnant women. (See Zappers.)  

The herbal program kills remaining parasites throughout the body which cannot be reached by the electric current. It consists of black walnut hull tincture, wormwood capsules, and cloves taken over 3 weeks. A weekly maintenance program is then recommended to prevent reinfection from the home, pets, undercooked dairy products and undercooked meat. She believed uncooked meat is the main source of intestinal flukes.  

She contended that isopropyl alcohol is a key pollutant. Foods and products polluted with isopropyl alcohol include shampoo, hair spray and mousse, cold cereals, cosmetics, mouthwash, decaffeinated coffee, vitamins, minerals and supplements, bottled water (polluted with antiseptics from the bottling procedure), rubbing alcohol, white sugar, shaving supplies, carbonated beverages and store-bought fruit juice. Dr. Clark recommends homemade products, unprocessed foods and a limited number of tested supplements. Once you stop using isopropyl alcohol, it disappears from your body within three days.  

When isopropyl alcohol is present in the body, the intestinal fluke uses another organ as a secondary host and that organ becomes cancerous. Other solvents in the body produce other diseases. For example, benzene causes the intestinal fluke to use the thymus for its secondary host, ruins the immune system and AIDS develops. Wood alcohol invites pancreatic flukes to use the pancreas as a secondary host and diabetes develops. Dr. Clark states that cancer could be eliminated if laws required testing for solvents in animal feeds and human foods. A significant reason for isopropyl alcohol pollution is the chemicals used by manufacturers to sterilize food-handling equipment.  

After cancer is stopped, the patient can get well if the toxins that invited parasites, bacterial, and viral invaders are removed. Removing toxins from the affected organs lets them heal. For example, lung lesions will not heal unless cigarette smoking, Freon, asbestos, and fiberglass exposure is stopped.  

Carcinogens draw the cancer to the organ: nickel draws cancer to the prostate, barium draws cancer to the breast. Dr. Clark considers the most serious threats to be: Freon (CFCs or refrigerant), copper from water pipes, fiberglass or asbestos, mercury from amalgam tooth fillings, lead from joints in copper plumbing, formaldehyde in foam bedding and new clothing, and nickel, usually from dental metal.  

Dental, diet, body, and home clean-ups aim to remove parasites and pollutants at their source. The body constantly fights to remove pollutants, but if you are being “re-supplied” with them, the body cannot heal. See Dr. Clark Cleanups.  

The dental clean up has been found crucial in shrinking tumors and restoring health. This is subject on which many alternative cancer experts agree. Dr. Clark advises:  

  • Remove all metals and large plastic fillings from the mouth.  
  • Remove all infected teeth and clean cavitations 

Silver or amalgam fillings contain 48-55% mercury, 33-35% silver, and various amounts of copper, tin, zinc, and other metals that corrode and seep into the body. Mercury is continually released from mercury fillings in the form of mercury vapor and abraded particles, which can be increased 15-fold by chewing, brushing, and hot liquids. Research has shown that mercury, even in small amounts, damages the brain, heart, lungs, liver, kidneys, thyroid, pituitary and adrenal glands, blood cells, enzymes, and hormones, and suppresses the body’s immune system.  

At the beginning of the 20th century Dr. Weston Price, head of the American Dental Association, found that root canal therapy, often used to save a tooth that has become infected or dead, had serious side effects. He showed thousands of instances of disease created from devitalized (i.e. dead) teeth, from head and neck pain to rheumatism and cancer. Most patients with devitalized teeth had thyroid dysfunction. The dental establishment, heavily committed to mercury amalgam fillings and root canals, ignored his findings. Safe treatment requires extracting the dead tooth rather than filling the root, and removing any infected tissue from around the tooth. Later the space can be filled with a bridge or partial denture.  

Personal care products — particularly petroleum products, alcohol, asbestos, colorings, dyes, formaldehyde, and perfume—are often toxic. These chemicals were not in use fifty or sixty years ago. Likewise for many other substances that have found their way into the human body. The tested ingredients in 99% of perfumes are labeled as toxic hazards and are not allowed in the agriculture industry. So, apart from avoidance of processed foods, Dr. Clark warns against commercial salves, ointments, lotions, colognes, perfumes, deodorants, toothpaste, soaps, washing powders etc. and gives recipes for homemade substitutes, e.g. borax powder for cleaning.  

Cleaning up the home environment to make it safe includes:  

  • Removing paints, varnishes, thinners, cleaners, and chemicals from the house.  
  • Sealing cracks around pipes.  
  • Changing CFC-cooled refrigerators for non CFC ones (Dr. Clark found Freon concentrated in cancerous organs, where it facilitates the accumulation of other toxins).  
  • Checking air conditioners for leaks.  
  • Sealing or removing uncovered fiberglass.  
  • Removing clothes dryers, hair dryers containing asbestos and old radiators and electric heaters which give off asbestos.  
  • Changing copper plumbing to PVC plastic.  

She suggests if you have been quite ill to move to a warm climate where you can avoid heating and cooling, and spend more time outdoors.  

Clark recommended the Syncrometer, a device that makes it possible to test exactly which toxins and parasites cause a patient’s cancer. The Syncrometer can be used for diagnosing and monitoring progress until cured. It consists of an audio oscillator circuit, which includes the body as part of the circuit. Dr. Clark maintained that every living and non-living entity produced certain specific frequencies which can be heard with the audio oscillator. Every living creature broadcasts its presence like a radio station.  

The Syncrometer tests for parasites or pollutants in any product or body tissue by using samples of those parasites or pollutants. Cancerous tumors grow in the body for at least three years before they are big enough to be detected by medical imaging techniques, but according to advocates, the Syncrometer can detect them long before that.  

For detoxifying the body, Dr. Clark recommends vitamins, minerals, and herbs from safe sources. Apart from parasite and dental cleanses, she gives detailed instructions for liver, kidney, and bowel cleanses. She recommends that the liver cleanse should not be done if the liver contains living parasites, and is best carried out after a parasite cleanse and then a kidney cleanse. The liver cleanse is reportedly the single most important thing you can do for your health. Medical herbalists, naturopaths and other natural healers speak highly of her cleanses.  

Thousands of testimonials exist acclaiming her methods and the success people have achieved through using them. A booklet of a thousand testimonials is available for $10 from the Dr. Clark Information Center, located at  See Dr. Clark Cleanups. SOURCE: Alternative Cancer Research Institute 

Further Reading & References  

  • The Cure for All Diseases by Hulda Regehr Clark (1995)  
  • The Cure For All Advanced Cancers by Hulda Regehr Clark (1999)  
  • The Cure for All Cancers: Including over 100 Case Histories of Persons Cured by Hulda Regehr Clark (1993)  
  • The Cure and Prevention of all Cancers by Hulda Regehr Clark (2008)  
  • The Cure For HIV / AIDS by Hulda Regehr Clark (2002)  
  • Syncrometer Science Laboratory Manual by Hulda Regehr Clark (2000)  
  • “University of Washington study shows the Dr. Clark zapper inhibits the growth of leukemia cells’”  
  • Dr. Clark Information Center,  
About the Kelley / Gonzales Protocol

William D. Kelley, DDS was a dentist who claimed to have healed himself of pancreatic cancer with his own therapy in 1964. The Kelley Anti-Cancer Program combines therapeutic nutrition, supplements, and vigorous detoxification of the body. His healing program was based on metabolic typing with the goal of providing a patient-specific dietary program, detoxification (using coffee enemas —a recognized detoxification therapy—and other therapies), neurological stimulation through chiropractic adjustment, and supplements of vitamins, minerals, and enzymes.  

Dr. Kelley believed the root cause of cancer is the body’s inability to digest and utilize (essentially, metabolize) protein. He stated: “The person gets cancer because he’s not properly metabolizing the protein in his diet. Then, to make matters worse, the tumor has such a high metabolism that it uses up much of the food which is eaten.  

“If a person’s disordered protein metabolism is not corrected it will give rise to more tumors in the future, even if the first one is successfully removed. This, by the way, is the unfortunate reason why so many seemingly successful cancer operations end up in recurrences a year or two later. The tumor was removed, but the cause—improper protein metabolism—remained.”  

Dr. Kelley linked faulty metabolism to a deficiency of pancreatic enzymes which he regarded as a fundamental cause of cancer. He believed that certain pancreatic enzymes, especially those that are proteolytic (protein-digesting) enzymes, are the body’s first line of defense against malignancy. This theory stands in marked contrast to the view that the immune system, with its natural killer cells, is the body’s main line of defense against cancer. (See Proteolytic Enzymes.)  

The pancreas releases enzymes directly into the small intestine to aid digestion. But Kelley maintained that the pancreas also secretes enzymes into the bloodstream, where they circulate, reaching all body tissues, and killing cancer cells by digesting them. Studies in the clinical literature lend support to this theory, first proposed by Dr. John Beard, a Scottish embryologist working at the turn of the century.  

Imbalance of mineral metabolism is another condition that allows malignancy to occur, according to Dr. Kelley. He identified mineral imbalance as a root cause of the breakdown of the immune system.  

Additionally, he said, cancer cells produce immune-blocking factors and seem to generate an electromagnetic force field that inhibits the proper response of the immune system.  

To demonstrate his theories, Kelley divided people into what he called ten metabolic types, with slow-oxidizing vegetarians at one extreme and fast-oxidizing carnivores at the other. Each person is different, he asserted, not only in nutritional needs but also in the way their bodies use food.  

Kelley then recommended a different nutritional program for each of the ten different metabolic types. An individualized diet was tailored to match the metabolic character of each patient, taking into account his or her physiology, neurological and physical makeup, basic metabolic rate, and personality. Some common threads ran through the diets, however. The consumption of raw, organic fruits, and vegetables was emphasized, while protein intake was reduced considerably to preserve the enzymes needed to digest fruits and vegetables.  

In addition to a diet, Kelley’s patients also took as many as 150 supplement pills per day, including pancreatic enzymes, vitamins and minerals, and concentrates of raw beef or organs and glands, believed by Kelley to contain tissue-specific growth factors, hormones, natural stimulants, and protective molecules. A direct anti-tumor effect has been observed repeatedly in patients on various metabolic therapies, who receive enzymes either orally or by injection. According to Kelley, as the enzymes “digest” the tumor, large amounts of cellular debris are released into the bloodstream and surrounding tissues.  

These breakdown products from cancer cells are foreign to the normal body and can be very toxic, he maintained. Even though the liver and kidney can filter these substances out of the bloodstream, the wastes from tumor destruction form so quickly during enzyme therapy that the body’s normal detoxification processes may become overloaded. To assist their bodies in detoxification, Kelley’s patients periodically discontinued their enzymes and other supplements for several days. 

This rest period, Kelley believed, allows the liver and kidneys to catch up with the body’s load of tumor byproducts.  

As a second aid in detoxification, Kelley advised all his patients to take at least one coffee enema daily.  

His reasoning was that coffee enemas clean out the liver and gallbladder and help the body get rid of the toxins produced during tumor breakdown. During a coffee enema, claimed Kelley, the caffeine that is rapidly absorbed in the large intestine flows quickly into the liver. He believed that in high enough concentrations, caffeine causes the liver and gallbladder to contract vigorously, releasing large amounts of stored wastes into the intestinal tract and greatly aiding elimination. Kelley also believed that enemas are important in stimulating the immune system, since most waste products eliminated by detoxification are enzyme inhibitors. Frequent enemas prevent the suppression of protein-digesting enzymes.  

These enzymes can break down the cancer cells’ fibrin (protein) coats, making the cancer cells more vulnerable to the immune system. See Coffee Enemas.  

The Merck Medical Manual, commonly thought to be the “bible of physicians”, included coffee enemas as an accepted means of detoxification and constipation relief up through 1977. Despite that, coffee enemas, common also to the Gerson Therapy, became the focal point of opponents who considered Kelley’s program unscientific.  

The original Kelley program also included purges to cleanse the liver, gallbladder, intestines, kidneys, and lungs. Like many other metabolic therapists, Kelley believed that the functioning of these organs is severely impaired in the cancer patient. Colonic irrigations, liver and gallbladder flushes, and controlled sweating accomplished the cleansing tasks. Kelley also often recommended some form of manipulative therapy, such as chiropractic adjustment or osteopathic manipulation, to stimulate sluggish nerves.  

A frequently overlooked part of the Kelley system is its spiritual component. Kelley called his approach metabolic ecology, taking into account the cancer patient’s total environment, including physical, mental, emotional, and spiritual aspects. He urged his patients to “accept the fact that you are afflicted with a symptom (malignant cancer) and that recovery is possible. Establish a faith in a power greater than yourself and know that with His help you can regain health and harmony.”  

Patients were encouraged to conduct a searching self-analysis and to eliminate negative behavioral patterns and emotions.  

The Kelley approach boasts extensive documentation with 10,000 medically-verified diagnoses. In one study, all his cases of pancreatic cancer were investigated. With conventional treatment, there were virtually no survivors after 5 years. He had 22 cases on record. Of these, 10 never started the treatment and survived for 67 days. 7 followed it partially and survived an average of 233 days, while the 5 who followed the Kelley treatment all completely recovered.  

Interest in Kelley’s therapy has increased dramatically in recent years largely due to the work of Nicholas Gonzalez, M.D., a New York City physician who treats cancer patients in advanced or terminal stages using a modified version of the Kelley program. A graduate of Cornell University Medical School, Dr. Gonzalez undertook a five-year case study of cancer patients of Kelley’s who did well on the program.  

The late Harold Ladas, Ph.D., a biologist and former professor at Hunter College, wrote:  

“Gonzalez has given us convincing evidence that diet and nutrition produce long-term remission in cancer patients almost all of whom were beyond conventional help.  

“Because the cases [in Gonzalez’s study] represent a wide variety of cancers, the implication is that the paradigm has wide applicability to cancer treatment. …What should happen is that ACS [American Cancer Society] or NCI [National Cancer Institute] should immediately follow up with a half million dollar study to evaluate the rest of Kelley’s cancer patients. But don’t hold your breath,” added Ladas, who concluded, “The evidence is in, and it is stunning. Kelley is vindicated.”  

In 1987, Dr. Gonzalez set up a private practice in New York City, where he began treating patients with a modified version of Dr. Kelley’s program.  

A pilot study of Dr. Gonzales treatment in patients with advanced pancreatic cancer was published in 1999. Of the 11 patients included in the study, 9 survived at least 1 year, 5 survived for 2 years, and 4 lived for 3 years. Two of the patients remained alive 4 years later. In contrast, the median survival for patients with inoperable pancreatic cancer who undergo chemotherapy is 5 ½ months. A further clinical study involving patients diagnosed with pancreatic cancer is expected.  

Like Kelley, whom the American Cancer Society denounced as a quack, Gonzalez has also been castigated for “departing from accepted practice.”  Dr. Gonzales program and its theory are described at . SOURCE: Alternative Cancer Research Institute 

Further Reading & References